Month: October 2022

《Sustainable and recyclable heterogenous palladium catalysts from rice husk-derived biosilicates for Suzuki-Miyaura cross-couplings, aerobic oxidations and stereoselective cascade carbocyclizations》 was written by Afewerki, Samson; Franco, Ana; Balu, Alina M.; Tai, Cheuk-Wai; Luque, Rafael; Cordova, Armando. Product Details of 15854-87-2 And the article was included in Scientific Reports in 2020. The article conveys some information:

Abstract: A new eco-friendly approach for the preparation of sustainable heterogeneous palladium catalysts from rice husk-derived biogenic silica (RHP-Si and RHU-Si). The designed heterogeneously supported palladium species (RHP-Si-NH2-Pd and RHU-Si-NH2-Pd) were fully characterized and successfully employed as catalysts for various chem. transformations (C-C bond-forming reactions, aerobic oxidations and carbocyclizations). Suzuki-Miyaura transformations were highly efficient in a green solvent system (H2O:EtOH (1:1) with excellent recyclability, providing the cross-coupling products with a wide range of functionalities in high isolated yields (up to 99%). Palladium species (Pd(0)-nanoparticles or Pd(II)) were also efficient catalysts in the green aerobic oxidation of an allylic alc. and a co-catalytic stereoselective cascade carbocyclization transformation. In the latter case, a quaternary stereocenter was formed with excellent stereoselectivity (up to 27:1 dr). In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Product Details of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Product Details of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《The Reactivity of Phosphanylphosphinidene Complexes of Transition Metals Toward Terminal Dihaloalkanes》 was written by Ordyszewska, Anna; Szynkiewicz, Natalia; Chojnacki, Jaroslaw; Pikies, Jerzy; Grubba, Rafal. Safety of 1,2-Diiodoethane And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

The reactivities of phosphanylphosphinidene complexes [(DippN)2W(Cl)(η2-P-PtBu2)]- (1), [(pTol3P)2Pt(η2-P:PtBu2)] (2), and [(dppe)Pt(η2-P:PtBu2)] (3) toward dihaloalkanes and Me iodide were investigated. The reactions of the anionic tungsten complex (1) with stoichiometric Br(CH2)nBr (n = 3, 4, 6) led to the formation of neutral complexes with a tBu2PP(CH2)3Br ligand or neutral dinuclear complexes with unusual tetradentate tBu2PP(CH2)nPPtBu2 ligands (n = 4, 6). The methylation of platinum complexes 2 and 3 with MeI yielded neutral or cationic complexes bearing side-on coordinated tBu2P-P-Me moieties. The reaction of 2 with I(CH2)2I gave a platinum complex with a tBu2P-P-I ligand. When the same dihaloalkane was reacted with 3, the P-P bond in the phosphanylphosphinidene ligand was cleaved to yield tBu2PI, phosphorus polymers, [(dppe)PtI2] and C2H4. Furthermore, the reaction of 3 with Br(CH2)2Br yielded dinuclear complex bearing a tetraphosphorus tBu2PPPPtBu2 ligand in the coordination sphere of the platinum. The mol. structures of the isolated products were established in the solid state and in solution by single-crystal x-ray diffraction and NMR spectroscopy. DFT studies indicated that the polyphosphorus ligands in the obtained complexes possess structures similar to free phosphenium cations tBu2P+:P-R (R = Me, I) or (tBu2P+:P)2. The phosphanylphosphinidene complexes of tungsten and platinum as building blocks for syntheses of polydentate phosphorus ligands. In the experiment, the researchers used 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Horan, Alexandra M.; Duong, Vincent K.; McGarrigle, Eoghan M. published their research in Organic Letters in 2021. The article was titled 《Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts》.Formula: C5H4IN The article contains the following contents:

Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Points, Gary L. III; Beaudry, Christopher M. published their research in Organic Letters in 2021. The article was titled 《Regioselective Synthesis of Substituted Carbazoles, Bicarbazoles, and Clausine C》.Synthetic Route of C6H5ClIN The article contains the following contents:

Substituted carbazoles are efficiently constructed from 3-triflato-2-pyrones and alkynyl anilines. Multiple substituents are tolerated on the carbazole, and complete control of regiochem. is observed Complicated and sterically congested substitution patterns are produced. This strategy is also used to prepare substituted bicarbazoles and related biaryls. Finally, the method was showcased in a synthesis of the carbazole natural product clausine C. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Synthetic Route of C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Synthetic Route of C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Rodrigues Silva, Daniela; de Azevedo Santos, Lucas; Hamlin, Trevor A.; Fonseca Guerra, Celia; Freitas, Matheus P.; Bickelhaupt, F. Matthias published their research in ChemPhysChem in 2021. The article was titled 《The Gauche Effect in XCH2CH2X Revisited》.SDS of cas: 624-73-7 The article contains the following contents:

We have quantum chem. investigated the rotational isomerism of 1,2-dihaloethanes XCH2CH2X (X = F, Cl, Br, I) at ZORA-BP86-D3(BJ)/QZ4P. Our Kohn-Sham MO (KS-MO) analyses reveal that hyperconjugative orbital interactions favor the gauche conformation in all cases (X = F-I), not only for X = F as in the current model of this so-called gauche effect. We show that, instead, it is the interplay of hyperconjugation with Pauli repulsion between lone-pair-type orbitals on the halogen substituents that constitutes the causal mechanism for the gauche effect. Thus, only in the case of the relatively small fluorine atoms, steric Pauli repulsion is too weak to overrule the gauche preference of the hyperconjugative orbital interactions. For the larger halogens, X···X steric Pauli repulsion becomes sufficiently destabilizing to shift the energetic preference from gauche to anti, despite the opposite preference of hyperconjugation. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7SDS of cas: 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.SDS of cas: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Xiong, Shuangyu; Sun, Wei; Chen, Rong; Yuan, Zhiqiang; Cheng, Xinjian published an article in 2021. The article was titled 《Fluorescent dialdehyde-BODIPY chitosan hydrogel and its highly sensing ability to Cu2+ ion》, and you may find the article in Carbohydrate Polymers.Safety of 1-Iodopyrrolidine-2,5-dione The information in the text is summarized as follows:

Fluorescent hydrogel with proper hydrophilicity and thermal stability, excellent sensitivity and high selectivity has important practical and scientific significance, especially in heavy metal ion detection. In this work, by adjusting the content of [2, 6-Bis-[4-formylthiophene]]-1,3,5,7-tetramethyl-8-phenyl-4, 4-difluoroborazaindoloene (B3), as a crosslinking agent, a series of chitosan- fluoroboron dipyrrole-chitosan-based fluorescent hydrogels (CBC) with large stokes shift were designed and prepared The hydrogels can be used as fluorescent probes for identifying Cu2+ in aqueous solution The linear quenching range of Cu2+ is 0-50 μM, and the detection limit and quenching constant are 4.75 μM and 3.52 x 104 M-1, resp. Under the interaction of Cu2+, the imine bond C=N was converted to C- N bond, which causes the phenomenon of fluorescence quenching. In addition, relatively high crosslink d. improves hydrophilicity and thermal stability of initial chitosan, and made the swelling ability better. The experimental part of the paper was very detailed, including the reaction process of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Safety of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Safety of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shi, Qinjie; Ji, Yuanyuan; Shi, Yanxia; Zhao, Zhenjiang; Zhu, Weiping; Xu, Yufang; Li, Baoju; Qian, Xuhong published an article in 2021. The article was titled 《Fluoro-pyrazolo[3,4-d]pyrimidine derivative as a novel plant activator induces two-pathway immune system》, and you may find the article in Phytochemistry (Elsevier).Application of 626-02-8 The information in the text is summarized as follows:

Plants are known to develop a multi-faceted innate immune system for pathogenic defense. Systemic acquired resistance (SAR) and induced systemic resistance (ISR) are the two main pathways. Many chem. inducers known as plant activators that activate innate immunity to defend against pathogens have been discovered. Currently, the exploitation of new plant activators is mainly done to develop analogs of salicylic acid as SAR-signaling mols.; however, the ISR pathway is hardly investigated for new plant activators. Based on recent studies on 1-methylpyrazolo[3,4-d]pyrimidine bioactivity and ATP-induced resistance to biotrophic and necrotrophic pathogens, a new lead compound, 1-methyl-4-amino-pyrazolo[3,4-d]pyrimidine, was obtained as a new scaffold of plant activators for possible inducing ISR immunity system. Addnl., fluorine atom plays an important role in the design and development of new pesticides due to the unique phys. chem. effect, a series of pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesized. Several compounds showed good broad-spectrum induced resistance in vivo, but there was no direct antibacterial activity in vitro. Notably, the introduction of fluorine atom at the para-position of the benzene ring greatly enhanced the induction activity of I both involved in SAR and ISR pathways, which implied the inducing resistance both in defending pathogens and insects. In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Application of 626-02-8)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Application of 626-02-8 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Zhang, Jianyu; Alam, Parvej; Zhang, Siwei; Shen, Hanchen; Hu, Lianrui; Sung, Herman H. Y.; Williams, Ian D.; Sun, Jianwei; Lam, Jacky W. Y.; Zhang, Haoke; Tang, Ben Zhong published an article in Nature Communications. The title of the article was 《Secondary through-space interactions facilitated single-molecule white-light emission from clusteroluminogens》.Recommanded Product: 4-Iodobenzaldehyde The author mentioned the following in the article:

Clusteroluminogens refer to some non-conjugated mols. that show visible light and unique electronic properties with through-space interactions due to the formation of aggregates. Although mature and systematic theories of mol. photophysics have been developed to study conventional conjugated chromophores, it is still challenging to endow clusteroluminogens with designed photophys. properties by manipulating through-space interactions. Herein, three clusteroluminogens with non-conjugated donor-acceptor structures and different halide substituents are designed and synthesized. These compounds show multiple emissions and even single-mol. white-light emission in the crystalline state. The intensity ratio of these emissions is easily manipulated by changing the halide atom and excitation wavelength. Exptl. and theor. results successfully disclose the electronic nature of these multiple emissions: through-space conjugation for short-wavelength fluorescence, through-space charge transfer based on secondary through-space interactions for long-wavelength fluorescence, and room-temperature phosphorescence. The introduction of secondary through-space interactions to clusteroluminogens not only enriches their varieties of photophys. properties but also inspires the establishment of novel aggregate photophysics for clusteroluminescence. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Rao, Qing; Xie, Kaiqiang; Varier, Krishnapriya M.; Huang, Lei; Song, Jingrui; Yang, Jue; Qiu, Jianfei; Huang, Yubing; Li, Yan; Gajendran, Babu; Li, Yanmei; Liu, Sheng published an article in Frontiers in Pharmacology. The title of the article was 《Design, synthesis, and antileukemic evaluation of a novel mikanolide derivative through the Ras/Raf/MEK/ERK pathway》.SDS of cas: 63069-48-7 The author mentioned the following in the article:

Chronic myeloid leukemia (CML) accounts for a major cause of death in adult leukemia patients due to mutations or other reasons for dysfunction in the ABL proto-oncogene. The ubiquitous BCR-ABL expression stimulates CML by activating CDK1 and cyclin B1, promoting pro-apoptotic, and inhibiting antiapoptotic marker expression along with regulations in RAS pathway activation. Thus, inhibitors of cyclins and the RAS pathway by ERK are of great interest in antileukemic treatments. Mikanolide is a sesquiterpene dilactone isolated from several Asteraceae family Mikania sp. plants. Sesquiterpene dilactone is a traditional medicine for treating ailments, such as flu, cardiovascular diseases, bacterial infections, and other blood disorders. It is used as a cytotoxic agent as well. The need of the hour is potent chemotherapeutic agents with cytotoxic effects inhibition of proliferation and activation of apoptotic machinery. Recently, ERK inhibitors are used in clinics as anticancer agents. Thus, in this study, authors synthesized 22-mikanolide derivatives that elucidated to be potent antileukemic agents in vitro. However, a bioactive mikanolide derivative, I, was found with potent antileukemic activity, through the Ras/Raf/MEK/ERK pathway. It can arrest the cell cycle by inhibiting phosphorylation of CDC25C, triggering apoptosis, and promoting DNA and mitochondrial damage, thus suggesting it as a potential chemotherapeutic agent for leukemia patients. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Park, Soyoon; Ryu, Soomin; Ho, Dongil; Chae, Wookil; Earmme, Taeshik; Kim, Choongik; Seo, SungYong published an article in New Journal of Chemistry. The title of the article was 《Novel benzo[b]thieno[2,3-d]thiophene derivatives with an additional alkyl-thiophene core: synthesis, characterization, and p-type thin film transistor performance》.Recommanded Product: 516-12-1 The author mentioned the following in the article:

In this paper, three novel organic materials based on the benzo[b]thieno[2,3-d]thiophene (BTT) core structure with an addnl. alkyl-thiophene core and end-capping alkyl side chains were synthesized and characterized. Furthermore, we explored the potential use of these compounds as solution-processed organic semiconductors (OSCs) for organic thin film transistors (OTFTs). Thermal, optical, and electrochem. properties of three organic compounds were investigated for elucidating the physicochem. information of each compound Then, the solution-shearing (SS) method was employed to form thin films of the compounds due to its merit with regard to mol. packing and thin film crystallinity, and microstructure as well as crystallinity of the thin films were investigated with θ-2θ X-ray diffraction (XRD) and at. force microscopy (AFM). All fabricated OTFTs exhibited p-channel activity under ambient conditions, and especially transistors based on the BTT core structure with a branched alkyl chain featured hole mobility up to 0.057 cm2 V-1 s-1 (VDS = -100 V) and current on/off ratio exceeding 107, in accordance with thin films of the corresponding compound showing superb surface coverage and high film texture. In the experiment, the researchers used many compounds, for example, 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Recommanded Product: 516-12-1)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Recommanded Product: 516-12-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com