Month: October 2022

《A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo[f]chromene molecules, targeting dual inhibition of topoisomerase II and microtubules》 was published in Bioorganic Chemistry in 2020. These research results belong to Fouda, Ahmed M.; Okasha, Rawda M.; Alblewi, Fawzia F.; Mora, Ahmed; Afifi, Tarek H.; El-Agrody, Ahmed M.. COA of Formula: C7H5IO The article mentions the following:

A series of β-enamionitriles, linked to the 8-bromo-1H-benzo[f]chromene moieties I (Ar = 2-ClC6H4, 4-IC6H4, 2,6-F2C6H3, etc.), was designed and synthesized under microwave irradiation conditions. Furthermore, the antiproliferative properties were evaluated against the human cancer cell lines MCF-7, HCT-116, and HepG-2 in comparison to the pos. controls Vinblastine and Doxorubicin, employing the viability assay. The obtained results confirmed that most of the tested mols. revealed strong and selective cytotoxic activities against the three cancer cell lines. The most potent cytotoxic compounds I (Ar = 2-ClC6H4, 4-ClC6H4, 4-BrC6H4, 2,3-Cl2C6H3, 2,5-Cl2C6H3) were elected for further examination, such as cell cycle anal., apoptosis assay, Caspase production, and DNA fragmentation. This study also revealed that the desired compounds stimulate cell cycle arrest at the G2/M phases, increase the production of Caspases 3, 8, and 9, and finally cause intrinsic and extrinsic apoptotic cell death. Moreover, these compounds suppress the action of topoisomerase II enzyme and also disrupt the microtubule functions. The SAR study of the synthesized compounds verified that the substitution on the Ph ring of the 1H-benzo[f]chromene nucleus, accompanied with the presence of the bromine atom at the 8-position, increases the ability of these mols. against different cell lines. After reading the article, we found that the author used 4-Iodobenzaldehyde(cas: 15164-44-0COA of Formula: C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.COA of Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Unconventional Reactivity of Ethynylbenziodoxolone Reagents and Thiols: Scope and Mechanism》 was published in Chemistry – A European Journal in 2020. These research results belong to Liu, Bin; Alegre-Requena, Juan V.; Paton, Robert S.; Miyake, Garret M.. COA of Formula: C7H5IO2 The article mentions the following:

Herein, a general and efficient strategy utilizing ethynylbenziodoxolone (EBX) reagents I (R2 = t-Bu, C6H5, 4-FC6H4, etc.) and thiols is presented that results in the formation of 1,2-dithio-1-alkenes II (R1 = C6H5, c-hexyl, 2-pyridyl, etc.; R2 = C6H5, 3-MeOC6H4, 3-ClC6H4, etc.) with excellent regioselectivity and stereoselectivity through unprecedented reactivity between the EBX and the thiol. This operationally simple procedure utilizes mild conditions, which result in a broad substrate scope and high functional-group tolerance. The observed unexpected reactivity has been rationalized through both exptl. results and DFT calculations After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5COA of Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. COA of Formula: C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Copper-Catalyzed Modular Assembly of Polyheterocycles》 was written by Wang, Qian; Tuinhof, Jesse; Mgimpatsang, Kumchok C.; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Doemling, Alexander. Related Products of 88-67-5 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Easy operation, readily accessible starting materials, and short synthesis of the privileged scaffold indeno[1,2-c]isoquinolinones I (R1 = H, 3-MeO, 2-Me, 2-NO2, etc.; R2 = H, Me, cyclopentyl, 4-chlorophenyl, etc.; R3 = tert-Bu, benzyl, 2-methoxy-2-oxoethyl, 2-ethylphenyl, etc.; R4 = H, 8,9-dimethoxy) were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodol. allows an efficient construction of a wide variety of indenoisoquinolinones I in just two steps. The experimental process involved the reaction of 2-Iodobenzoic acid(cas: 88-67-5Related Products of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Carboxylic Acid Deoxyfluorination and One-Pot Amide Bond Formation Using Pentafluoropyridine (PFP)》 was written by Brittain, William D. G.; Cobb, Steven L.. SDS of cas: 88-67-5 And the article was included in Organic Letters in 2021. The article conveys some information:

The present work describes the application of pentafluoropyridine (PFP), a cheap com. available reagent, in the deoxyfluorination of carboxylic acids RC(O)OH (R = Et, adamantan-1-yl, Ph, 2-iodophenyl, etc.) to acyl fluorides RC(O)F. The acyl fluorides can be formed from a range of acids under mild conditions. The PFP that can be utilized in a one-pot amide bond formation via in situ generation of acyl fluorides was also demonstrated. This one-pot deoxyfluorination amide bond-forming reaction gives ready access to amides RC(O)N(R1)R2 (R1 = H, Me, Et; R2 = Et, Ph, 3-nitrophenyl, etc.) in yields of ≤94%. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5SDS of cas: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 88-67-5Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sun, Xu; Guo, Xiao-Qiang; Chen, Lian-Mei; Kang, Tai-Ran published their research in Chemistry – A European Journal in 2021. The article was titled 《Synthesis, Characterization of Spirocyclic λ3-Iodanes and Their Application to Prepare 4,1-Benzoxazepine-2,5-diones and 1,3-Diynes》.Related Products of 625-99-0 The article contains the following contents:

Herein, a [3+2] cycloaddition of aza-oxyallylic cations I [R = H, 6-Cl, 5-NO2, 5-F; R1 = 2-bromophenyl, 4-(ethoxycarbonyl)benzen-1-yl, tris(propan-2-yl)silyl, etc.] with ethynylbenziodoxolones R2ONHC(O)C(CH3)2Br [R2 = allyl, i-Pr, Bn, (2,4-dichlorophenyl)methyl, etc.] for synthesis of new λ3-iodanes containing spirocyclic 4-oxazolidinone II is described. This cyclic λ3-iodanes II display stability in air and excellent solubility in organic solvent. Using the above compounds as substrate II, both the 4,1-benzoxazepine-2,5-diones III [R3 = Me, allyl, (2,4-dichlorophenyl)methyl, etc.; R4 = H, 7-Me, 8-Cl, 7-CF3] and sym. 1,3-diynes derivatives R5CCCCR5 [R5 = Ph, 2-bromophenyl, 1-naphthyl, etc.] were afforded in high yield under copper(I)-catalyzed conditions. After reading the article, we found that the author used 1-Chloro-3-iodobenzene(cas: 625-99-0Related Products of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.Related Products of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Samadi, Saadi; Ashouri, Akram; Rashid, Hersh I.; Majidian, Shiva; Mahramasrar, Mahsa published their research in New Journal of Chemistry in 2021. The article was titled 《Immobilization of (L)-valine and (L)-valinol on SBA-15 nanoporous silica and their application as chiral heterogeneous ligands in the Cu-catalyzed asymmetric allylic oxidation of alkenes》.Application of 619-58-9 The article contains the following contents:

SBA-15 nanoporous silica was synthesized by hydrothermal method using P123 surfactant and tetraethoxyortosilicate in acidic condition and then functionalized by 3-chloropropyltrimethoxysilane. Next, by immobilization of chiral amino acid (S)-2-amino-3-Me butanoic acid (L-valine) and chiral amino alc. (S)-2-amino-3-methylbutane-1-ol (L-valinol), prepared via the reduction of L-valine by NaBH4/I2 in THF, on functionalized-SBA-15, chiral heterogeneous ligands AL*-i-Pr-SBA-15 and AA*-i-Pr-SBA-15 were prepared and characterized by FT-IR, XRD, TGA, EDX, SEM, BET-BJH techniques. The asym. allylic oxidation of alkenes was done using copper-complexes of these ligands and the as-synthesized peresters. The reactions were optimized by varying various parameters such as temperature, solvent, amount of chiral heterogeneous ligand, as well as the type and amount of copper salt. Under optimized conditions, 6 mg of AL*-i-Pr-SBA-15 and 3.2 mol% of Cu(CH3CN)4PF6 in acetonitrile at 50°C, the chiral allylic ester was obtained with 80% yield and 39% enantiomeric excess in 24 h. The recyclability of the chiral heterogeneous catalysts was also evaluated without significant reduction in the reaction results up to three runs.4-Iodobenzoic acid(cas: 619-58-9Application of 619-58-9) was used in this study.

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine.Application of 619-58-9 In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mertens, R. Tyler; Greif, Charles E.; Coogle, James T.; Berger, Gilles; Parkin, Sean; Watson, Mark D.; Awuah, Samuel G. published an article in 2022. The article was titled 《Stable Au(I) catalysts for oxidant-free C-H functionalization with iodoarenes》, and you may find the article in Journal of Catalysis.Electric Literature of C6H5IO The information in the text is summarized as follows:

Herein, the development of novel tricoordinate Au(I) catalysts supported by N,N-bidentate ligands and ligated by phosphine or arsine ligands for C-H functionalization without external oxidants to form biaryls with no homocoupling was reported. The unsym. character of the Au(I) catalyst was critical to facilitating this necessary orthogonal transformation. This study unveils yet another potential of Au(I) catalysis in biaryl synthesis. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Electric Literature of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Electric Literature of C6H5IO Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Dong, Cong; Mai, Shaoyu; Wang, Shuai; Li, Xin; Song, Qiuling published an article in Organic Chemistry Frontiers. The title of the article was 《Base-promoted anaerobic intramolecular cyclization synthesis of 4,5-disubstituted-1,2,3-thiadiazoles》.Product Details of 591-18-4 The author mentioned the following in the article:

An alkali-promoted, transition-metal-free and oxidant-free method to construct 4,5-disubstituted-1,2,3-thiadiazoles I [R = 2-NO2, 3-NO2; R1 = H, 2-MeO, 4-F, etc.] from N-tosylhydrazone-bearing thiocarbamates by employing a sustainable intramol. reaction strategy had been developed. This reaction featured high efficiency and good functional group compatibility, readily available starting materials and valuable products. Furthermore, this method had great potential in the synthesis of natural products, pharmaceuticals and materials. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-iodobenzene(cas: 591-18-4Product Details of 591-18-4)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Product Details of 591-18-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Leushukou, Andrei A.; Krech, Anastasiya V.; Hurski, Alaksiej L. published an article in Organic Letters. The title of the article was 《Visible-Light-Promoted Nickel-Catalyzed Cross-Coupling of Alkyltitanium Alkoxides with Aryl and Alkenyl Halides》.SDS of cas: 15854-87-2 The author mentioned the following in the article:

The reported alkyltitanium alkoxides generated in situ from Grignard reagents and Ti(OiPr)4 undergone a photocatalyst-free nickel-catalyzed cross-coupling with organic halides upon irradation with blue light. Mechanistic studies suggested that the reaction proceeds through radical intermediates formed by photochem. decomposition of the alkyltitanium reagents. Various aryl, heteroaryl, and vinyl halides was efficiently alkylated under the reported conditions, including those containing ester and amide groups. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2SDS of cas: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.SDS of cas: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Suri Babu, Undamatla; Singam, Maneesh Kumar Reddy; Kumar, Muniganti Naveen; Nanubolu, Jagadeesh Babu; Sridhar Reddy, Maddi published an article in Organic Letters. The title of the article was 《Palladium-Catalyzed Carbo-Aminative Cyclization of 1,6-Enynes: Access to Naphthyridinone Derivatives》.Safety of 4-Chloro-2-iodoaniline The author mentioned the following in the article:

A general approach to naphthyridinones I [R = H, 8-Me, 7-F, etc.; Ar = Ph, 4-MeC6H4, Bn, etc.; Ar1 = Ph, 4-MeC6H4, 2-thienyl, etc.] was described via Pd-catalyzed annulation of 1,6-enynes with 2-iodoanilines. This protocol represents a rare carbo-aminative annulative cyclization via 6-endo-trig mode, subduing the well documented exo-trig/dig cyclizations. Regioselective aryl palladation of alkyne followed by Heck type intramol. coupling before isomerization were key in realizing this cascade. In addition to this study using 4-Chloro-2-iodoaniline, there are many other studies that have used 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com