Month: October 2022

In 2019,Organic Letters included an article by Tukhtaev, Hamidulla B.; Ivanov, Konstantin L.; Bezzubov, Stanislav I.; Cheshkov, Dmitry A.; Melnikov, Mikhail Ya.; Budynina, Ekaterina M.. Computed Properties of C3H9IOS. The article was titled 《aza-Wittig Reaction with Nitriles: How Carbonyl Function Switches from Reacting to Activating》. The information in the text is summarized as follows:

Transformations of α-EWG-substituted (electron-withdrawing group, EWG) γ-azidobutyronitriles proceeding via unusual aza-Wittig reactions between the phosphazene and nitrile functions and affording pyrrole-derived iminophosphazenes were developed. α-EWGs were found to control chemoselectivity and, depending on their nature, act as CN group activators (e.g., ester, amide, or nitrile) or competitors (e.g., ketone) in aza-Wittig reactions. To demonstrate the synthetic utility of the obtained iminophosphazenes as N,N-binucleophiles, their transformations into pyrrole-fused systems, pyrrolo[1,2-a]imidazoles and pyrrolo[1,2-a][1,3]diazepines, were carried out. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Computed Properties of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Computed Properties of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《A Mild and Regioselective Synthesis of α-Fluoroketones via Gold and Selectfluor Partnership》 were Chen, Xi; Martini, Sophie; Michelet, Veronique. And the article was published in Advanced Synthesis & Catalysis in 2019. Computed Properties of C6H4BrI The author mentioned the following in the article:

Alkynylaryl aldehydes and Me ketones such as I underwent regioselective fluorohydroxylation with Selectfluor in aqueous EtOH in the presence of Ph3PAuCl at ambient temperature to yield α-fluoro ketones such as II. The mechanism of the reaction was studied by the (lack of) reaction of diphenylacetylene and by deuterium labeling and intermediate studies. Selected fluoroketone, including II, were converted to 3-substituted 4-fluoroisoquinolines such as III. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-iodobenzene(cas: 591-18-4Computed Properties of C6H4BrI)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Computed Properties of C6H4BrI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Mechanism of Hypervalent Iodine Promoted Fluorocyclization of Unsaturated Alcohols: Metathesis via Double Acids Activation》 were Shu, Siwei; Li, Yinwu; Jiang, Jingxing; Ke, Zhuofeng; Liu, Yan. And the article was published in Journal of Organic Chemistry in 2019. Product Details of 624-31-7 The author mentioned the following in the article:

Lewis/Bronsted acid activation plays a key role in hypervalent iodine reagent-mediated reactions. In addition to generally accepted cis-activation or trans-activation, this study reveals another important Lewis/Bronsted acid activation mode, the double-activation. Different from the generally proposed iodine(III)iranium SN2 mechanism, the hypervalent difluoro-iodoarene-promoted fluorocyclization of unsaturated alc. prefers to undergo the metathesis mechanism via an iodine(III)-π intermediate. The results came from multiple reactions, including the reaction of 1-Iodo-4-methylbenzene(cas: 624-31-7Product Details of 624-31-7)

1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Product Details of 624-31-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Microwave-Assisted Synthesis of Core-Crosslinked Star Polymers with Benzophenone Derivatives in the Core》 were Kang, Tae-Hyeon; Lee, Hyung-il. And the article was published in Macromolecular Research in 2019. Recommanded Product: 4-Iodobenzoic acid The author mentioned the following in the article:

Core-crosslinked star polymers, which have polyethylene oxide (PEO) as a shell and cross-linked poly(2-{4′-iodobenzoyloxy}-Et methacrylate) (PIEMA) with benzophenone derivatives as a core, have been successfully synthesized by an “”arm-first”” method. PEO-b-PIEMA was prepared via atom transfer radical polymerization (ATRP) of 2-{4′-iodobenzoyloxy}-Et methacrylate (4-IEMA) with preformed PEO-Br as a macroinitiator. Core-crosslinked star polymers (CCSP) were efficiently synthesized by ultrafast carbonylation reactions under air by flash microwave irradiation in the presence of dicobalt octacarbonyl in 6 min. Gel permeation chromatog. (GPC) trace of CCSP showed a drastic shift to a higher mol. weight when compared to precursor polymer, PEO-b-PIEMA diblock copolymer, indicating that the carbonylation reaction was fully progressed. The CCSP with benzophenone was successfully immobilized on a silicon wafer through a photochem. reaction under UV irradiation The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Recommanded Product: 4-Iodobenzoic acid)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides.Recommanded Product: 4-Iodobenzoic acid The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Anode interfacial layer formation via reductive ethyl detaching of organic iodide in lithium-oxygen batteries》 were Zhang, Xiao-Ping; Sun, Yi-Yang; Sun, Zhuang; Yang, Chu-Shu; Zhang, Tao. And the article was published in Nature Communications in 2019. Electric Literature of C3H9IOS The author mentioned the following in the article:

As soluble catalysts, redox mediators can reduce the high charging overpotential of lithium-oxygen batteries by providing sufficient liquid-solid interface for lithium peroxide decomposition However, the redox mediators usually introduce undesirable reactions. In particular, the so-called “”shuttle effect”” leads to the loss of both the redox mediators and elec. energy efficiency. In this study, an organic compound, triethylsulfonium iodide, is found to act bifunctionally as both a redox mediator and a solid electrolyte interphase-forming agent for lithium-oxygen batteries. During charging, the organic iodide exhibits comparable lithium peroxide-oxidizing capability with inorganic iodides. Meanwhile, it in situ generates an interfacial layer on lithium anode via reductive Et detaching and the subsequent oxidation This layer prevents the lithium anode from reacting with the redox mediators and allows efficient lithium-ion transfer leading to dendrite-free lithium anode. Significantly improved cycling performance has been achieved by the bifunctional organic iodide redox mediator. In the part of experimental materials, we found many familiar compounds, such as Trimethylsulfoxonium iodide(cas: 1774-47-6Electric Literature of C3H9IOS)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Electric Literature of C3H9IOS

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Pd nanocatalyst adorning coral reef nanocomposite for the synthesis of nitriles: utility of Cucurbita pepo leaf extract as a stabilizing and reducing agent》 were Nasrollahzadeh, Mahmoud; Ghorbannezhad, Fatemeh; Sajadi, S. Mohammad; Varma, Rajender S.. And the article was published in Nanomaterials in 2019. Formula: C5H4IN The author mentioned the following in the article:

A simple procedure for the palladium-catalyzed cyanation of aryl halides is described via a nucleophilic non-toxic cyanide source, K4[Fe(CN)6] in the presence of Pd/coral reef nanocomposite as a heterogeneous catalyst; the protocol provides a useful and easy method for the synthesis of aryl nitriles that are generated from the corresponding variant aryl halides, with sodium carbonate as a base. The nanocatalyst was prepared by a biol. process using aqueous extract of leaves of Cucurbita pepo as a stabilizing and reducing agent and coral reef as a natural support, without deploying any hazardous chems. The catalyst, that is easily separable from the reaction mixture and reused multiple times, was characterized by FT-IR (Fourier-Transform IR Spectroscopy), ICP-AES (Inductively Coupled Plasma Atomic Emission Spectroscopy), XRD (X-ray Diffraction), TEM (Transmission Electron Microscopy), FE-SEM (Field Emission SEM), EDS (Energy Dispersive X-ray Spectroscopy) and elemental mapping. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Ortho C-H arylation of arenes at room temperature using visible light ruthenium C-H activation》 was published in Chemical Science in 2020. These research results belong to Sagadevan, Arunachalam; Charitou, Anastasios; Wang, Fen; Ivanova, Maria; Vuagnat, Martin; Greaney, Michael F.. Application In Synthesis of 1-Bromo-4-iodobenzene The article mentions the following:

A ruthenium-catalyzed ortho C-H arylation process is described using visible light. Using the readily available catalyst [RuCl2(p-cymene)]2, visible light irradiation was found to enable arylation of 2-aryl-pyridines I (R1 = 4-methoxyphenyl, naphthalen-2-yl, thiophen-2-yl, etc.; R2 = H, 2-Me, 4-Me, 5-Me) at room temperature for a range of aryl halides R3X (R3 = 2-methoxyphenyl, 4-phenylphenyl, thiophen-2-yl, etc.; X = I, Br). In the experimental materials used by the author, we found 1-Bromo-4-iodobenzene(cas: 589-87-7Application In Synthesis of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesApplication In Synthesis of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Copper-Catalyzed Three-Component Redox-Neutral Ring Opening of Benzothiazoles to 1-Amino-N-(2-(phenylthio)phenyl)methanimine》 was published in Journal of Organic Chemistry in 2020. These research results belong to Zheng, Nian; Liu, Ce; Ding, Ya-Nan; Shi, Wei-Yu; Zhang, Bo-Sheng; Liang, Yong-Min. SDS of cas: 90-14-2 The article mentions the following:

Copper-catalyzed three-component redox-neutral ring opening of benzothiazoles with aryl iodides and O-benzoyl hydroxylamines for the synthesis of 1-amino-N-(2-(phenylthio)phenyl)methanimine has been developed. This one-pot reaction undergoes C-S and N-O bond cleavage and new C-S and C-N bond construction. Several control experiments excluded a free radical procedure and also demonstrated the secondary amine as a possible intermediate, which was vital to the catalytic reaction. Meanwhile, the deuteration experiment got rid of the C-H activation dehydroisomerization of the benzothiazole mechanism. The experimental part of the paper was very detailed, including the reaction process of 1-Iodonaphthalene(cas: 90-14-2SDS of cas: 90-14-2)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.SDS of cas: 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Cobalt-Catalyzed Csp3-Csp3 Cross-Coupling of Functionalized Alkylzinc Reagents with Alkyl Iodides》 was published in Organic Letters in 2020. These research results belong to Lutter, Ferdinand H.; Grokenberger, Lucie; Benz, Maximilian; Knochel, Paul. Related Products of 301673-14-3 The article mentions the following:

A mild cobalt-catalyzed Negishi-type cross-coupling of various functionalized dialkylzinc reagents with primary and secondary alkyl iodides in acetonitrile is reported using a combination of 20% CoCl2 and chelating nitrogen ligands. The method allows the construction of mols. with alkyl chains bearing sensitive functional groups at room temperature The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Related Products of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Related Products of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Methylene C(sp3)-H β,β’-Diarylation of Cyclohexanecarbaldehydes Promoted by a Transient Directing Group and Pyridone Ligand》 was published in Organic Letters in 2020. These research results belong to St John-Campbell, Sahra; White, Andrew J. P.; Bull, James A.. Reference of 1-Iodo-4-methylbenzene The article mentions the following:

A hindered β-amino amide transient directing group effects di-trans-arylation of cyclohexanecarbaldehydes. The amide N-substituents were shown to affect yield and it was enhance the rate of arylation compared with the α-amino acid. Addition of a pyridone ligand further enhanced reactivity. The reaction was successful for a range of aryl iodides, and various substituted cyclohexane carboxaldehydes, providing functionalized products from simple feedstocks. A mechanism was proposed evoking a transient enamine. After reading the article, we found that the author used 1-Iodo-4-methylbenzene(cas: 624-31-7Reference of 1-Iodo-4-methylbenzene)

1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Reference of 1-Iodo-4-methylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com