Month: October 2022

Li, Xuemin; Zhang, Beibei; Zhang, Jingran; Wang, Xi; Zhang, Dongke; Du, Yunfei; Zhao, Kang published an article in 2021. The article was titled 《Synthesis of 3-Methylthioindoles via Intramolecular Cyclization of 2-Alkynylanilines Mediated by DMSO/DMSO-d6 and SOCl2》, and you may find the article in Chinese Journal of Chemistry.Reference of 4-Chloro-2-iodoaniline The information in the text is summarized as follows:

The intramol. cyclization of 2-alkynylanilines mediated by DMSO/SOCl2 was found to afford biol. interesting 3-methylthioindoles, which were rarely obtained by the exiting methods. DMSO could also be replaced with its deuterated counterpart, enabling the method applicable to the construction of indole skeleton bearing a SCD3 moiety at its 3-position. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7Reference of 4-Chloro-2-iodoaniline)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Reference of 4-Chloro-2-iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

He, Yuan; Liao, Xian-Zhang; Dong, Lin; Chen, Fen-Er published an article in 2021. The article was titled 《Rh(III)-Catalyzed three-component cascade annulation to produce the N-oxopropyl chain of isoquinolone derivatives》, and you may find the article in Organic & Biomolecular Chemistry.HPLC of Formula: 625-99-0 The information in the text is summarized as follows:

A novel three-component cascade annulation reaction to efficiently construct the N-oxopropyl chain of isoquinolone derivatives via rhodium(III)-catalyzed C-H activation/cyclization/nucleophilic attack was reported with oxazoles used both as the directing group and potential functionalized reagents. In the experiment, the researchers used many compounds, for example, 1-Chloro-3-iodobenzene(cas: 625-99-0HPLC of Formula: 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.HPLC of Formula: 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gollapelli, Krishna Kumar; Patil, Vaibhav B.; Vinaykumar, Allam; Chegondi, Rambabu published an article in 2021. The article was titled 《Rh(I)-catalyzed stereoselective desymmetrization of prochiral cyclohexadienones via highly exo-selective Huisgen-type [3 + 2] cycloaddition》, and you may find the article in Chemical Science.Synthetic Route of C7H5IO2 The information in the text is summarized as follows:

A Rh(I)-catalyzed highly stereoselective desymmetrization of 2-alkynylbenzaldehyde-tethered cyclohexadienones triggered by intramol. Huisgen-type [3 + 2] cycloaddition was developed. This method enables convergent construction of complex epoxy-bridged polycyclic ring systems with five contiguous stereocenters with excellent exo-selectivity and broad substrate scope. The highly atom-economical process involves 6-endo-dig cyclization of carbonyl oxygen onto an activated alkyne resulting in a highly reactive metal-benzopyrylium intermediate, which readily undergoes intramol. [3 + 2] annulation/hydration. Asym. induction was also achieved for the first time in Rh(I)-catalyzed 1,3-dipolar cycloaddition using an easily accessible chiral diene as the ligand. After reading the article, we found that the author used 2-Iodobenzoic acid(cas: 88-67-5Synthetic Route of C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C7H5IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Ma, Huan; Li, Feize; Shen, Guohua; Pan, Lili; Liu, Weihao; Liang, Ranxi; Lan, Tu; Yang, Yuanyou; Yang, Jijun; Liao, Jiali; Liu, Ning published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《In vitro and in vivo evaluation of 211At-labeled fibroblast activation protein inhibitor for glioma treatment》.Related Products of 619-58-9 The author mentioned the following in the article:

Glioma is the most common primary intracranial tumor without effective treatment. Positron emission tomog. tracers labeled with 68Ga targeting fibroblast activation protein (FAP) have shown favorable characteristics in the diagnosis of glioma. However, to the best of our knowledge, FAP-targeted endoradiotherapy has never been explored in glioma. Hence, in this study, we investigated the therapeutic effect of 211At-labeled fibroblast activation protein inhibitor (FAPI) for glioma in vitro and in vivo. By astatodestannylation reaction, we prepared 211At-FAPI-04 with a radiochem. yield of 45 ± 6.7% and radiochem. purity of 98%. With good stability in vitro, 211At-FAPI-04 showed fast and specific binding to FAP-pos. U87MG cells, and could significantly reduce the cell viability, arrested cell cycle at G2/M phase and suppressed cell proliferative efficacy. Biodistribution studies revealed that 6-fold higher accumulation in tumor sites was achieved by intratumoral injection in comparison with i.v. injection. In U87MG xenografts, 211At-FAPI-04 obviously suppressed the tumor growth and prolonged the median survival in a dose-dependent manner without obvious toxicity to normal organs. In addition, reduced proliferation and increased apoptosis were also observed after 211At-FAPI-04 treatment. All these results suggest that targeted alpha-particle therapy (TAT) mediated by 211At-FAPI-04 can provide an effective and promising strategy for the treatment of glioma. After reading the article, we found that the author used 4-Iodobenzoic acid(cas: 619-58-9Related Products of 619-58-9)

4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 619-58-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Sengupta, Manideepa; Das, Subhasis; Bhattacharya, Sumantra; Gazi, Jahiruddin; Prasad, V. V. D. N.; Islam, Sk Manirul; Bordoloi, Ankur published an article in Molecular Catalysis. The title of the article was 《Sustainable synthesis of drug intermediates via simultaneous utilization of carbon monoxide and ammonia over Pd@La-MOF》.Recommanded Product: 15854-87-2 The author mentioned the following in the article:

Mitigation of carbon monoxide and ammonia to valuable primary aromatic amides is an imperative approach to control the environmentally harmful emissions thereby infusing towards sustainability. Designing of nanostructured catalyst for direct access to the synthetically valuable primary aromatic and heteroaromatic amides via carbonylative amination of aryl halides is always demanding since nano materials can bridge the gap between homogeneous and heterogeneous catalysis thus preserving the desirable attributes of both the systems towards sustainable catalysis. Herein, microwave assisted fabrication of highly uniform Pd NPs (3,4 nm) over La-MOFs has been performed and utilized efficiently for ligand free carbonylative amination of aryl iodides with carbon monoxide and ammonia. Moderate to high yields of benzamide derivatives, salicylamide, a drug having analgesic and antipyretic properties were achieved. The unsaturated metal sites in the MOF via synergistic mode of σ and π bonding binds with CO, which significantly enhances the catalytic activity of MOF-composite unlike other supported Pd NPs. DFT confirms the growth of pristine Pd13 cluster within the framework, as active metal center for the carbonylative amination. In the experiment, the researchers used 4-Iodopyridine(cas: 15854-87-2Recommanded Product: 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Recommanded Product: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Fu, Jiayue; Li, Bingbing; Wang, Xiugui; Liang, Qida; Peng, Xiaoshi; Yang, Lu; Wan, Tao; Wang, Xinxiu; Lin, Bin; Cheng, Maosheng; Liu, Yongxiang published an article in Chinese Journal of Chemistry. The title of the article was 《Au(I)-Catalyzed 6-endo-dig Cyclizations of Aromatic 1, 5-Enynes to 2-(Naphthalen-2-yl)anilines Leading to Divergent Syntheses of Benzo[α]carbazole, Benzo[c,h]cinnoline and Dibenzo[i]phenanthridine Derivatives》.SDS of cas: 63069-48-7 The author mentioned the following in the article:

A gold(I)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines. The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed. The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole, benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.SDS of cas: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Hess, A.; Guelen, H. C.; Alandini, N.; Mourati, A.; Guersoy, Y. C.; Knochel, P. published an article in Chemistry – A European Journal. The title of the article was 《Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines》.Category: iodides-buliding-blocks The author mentioned the following in the article:

A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, Et cyanoformate or allylic bromides (39 examples, 62-99% yield) was reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50°C, 4 h) provided the corresponding nitriles I [R = H, 3-F, 4-OMe, etc.; R1 = I, CN, 3-MeC6H4, etc.; R2 = H, 2-thienyl, 1-naphthyl, etc.] (36 examples, 73-99% yield). After reading the article, we found that the author used 4-Iodopyridine(cas: 15854-87-2Category: iodides-buliding-blocks)

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 63069-48-7In 2021 ,《Visible-light-induced and copper-catalyzed oxidative cyclization of substituted o-aminophenylacetylene for the synthesis of quinoline and indole derivatives》 appeared in Organic Chemistry Frontiers. The author of the article were Huang, Quan; Zhao, Mingming; Yang, Yiqiang; Niu, Yan-Ning; Xia, Xiao-Feng. The article conveys some information:

Herein, the development of a mild and efficient intramol. oxidative cyclization reaction of substituted aromatic enamines and the C(sp3)-H bond adjacent to nitrogen with alkynes or alkenes, leading to multi-substituted quinolines and indoles using dioxygen as a green oxidant is reported. With visible light irradiation, a simple and cheap copper catalyst is able to functionalize the internal alkynes or alkenes via an intramol. radical cyclization strategy without any extra photosensitizers. Preliminary mechanistic studies including radical capture reactions, isotope labeling experiments, and fluorescence quenching study are also conducted. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Recommanded Product: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Recommanded Product: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application In Synthesis of 1-Bromo-3-iodobenzeneIn 2020 ,《Revealing Topological Influence of Phenylenediamine Unit on Physicochemical Properties of Donor-Acceptor-Donor-Acceptor Thermally Activated Delayed Fluorescent Macrocycles》 appeared in Chemistry – An Asian Journal. The author of the article were Izumi, Saika; Nyga, Aleksandra; de Silva, Piotr; Tohnai, Norimitsu; Minakata, Satoshi; Data, Przemyslaw; Takeda, Youhei. The article conveys some information:

A new thermally activated delayed fluorescence (TADF)-displaying macrocyclic compound m-1 comprising of two electron-donors (N,N’-diphenyl-m-phenylenediamine) and two electron-acceptors (dibenzo[a,j]phenazine) has been synthesized. The macrocycle developed herein is regarded as a regioisomer of the previously reported TADF macrocycle p-1, which has two N,N’-diphenyl-p-phenylenediamines as the donors. To understand the influence of the topol. of the phenylenediamine donors on physicochem. properties of TADF-active macrocycles, herein the mol. structure in the single crystals, photophys. properties, electrochem. behavior, and TADF properties of m-1 have been investigated compared with those of p-1. The substitution of p-phenylene donor with m-phenylene donor led to distinct pos. solvatoluminochromism over the full visible-color range, unique oxidative electropolymerization, and slightly lower contribution of TADF, due to the lower CT character in the excited states. After reading the article, we found that the author used 1-Bromo-3-iodobenzene(cas: 591-18-4Application In Synthesis of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Application In Synthesis of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2019 ,《Sigmoidal kinetics define porcine intestinal segregation of electrogenic monosaccharide transport systems as having multiple transporter population involvement》 was published in Physiological Reports. The article was written by Subramaniam, Marina; Enns, Cole B.; Loewen, Matthew E.. The article contains the following contents:

Kinetic characterization of electrogenic sodium-dependent transport in Ussing chambers of D-glucose and D-galactose demonstrated sigmoidal/Hill kinetics in the porcine jejunum and ileum, with the absence of transport in the distal colon. In the jejunum, a high-affinity, super-low-capacity (Ha/sLc) kinetic system accounted for glucose transport, and a low-affinity, low-capacity (La/Lc) kinetic system accounted for galactose transport. In contrast, the ileum demonstrated a high-affinity, super-high-capacity (Ha/sHc) glucose transport and a low-affinity, high-capacity (La/Hc) galactose transport systems. Jejunal glucose transport was not inhibited by dapagliflozin, but galactose transport was inhibited. Comparatively, ileal glucose and galactose transport were both sensitive to dapagliflozin. Genomic and gene expression analyses identified 10 of the 12 known SLC5A family members in the porcine jejunum, ileum, and distal colon. However, the sigmoidal kinetics and overall high capacity (Hc) of transport is unlikely accounted for by SGLT1 (SLC5A1) alone. Finally, the absence of transport and lack of pharmacol. inhibition in the colon was associated with the poor expression of SLC5A genes. This reveals multiple transporter populations in each system, supported by gene expression profiles and pharmacol. inhibition. Overall, this work demonstrates a complexity to transporter involvement in intestinal electrogenic monosaccharide absorption systems not previously defined. After reading the article, we found that the author used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Category: iodides-buliding-blocks)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com