Month: October 2022

Synthetic Route of C6H4ClIIn 2019 ,《Synthesis of terpyridine-containing Pd(II) complexes and evaluation of their catalytic activity》 appeared in Journal of Molecular Structure. The author of the article were Yin, Sanmao; Wang, Xiaomin; Jiang, Jun; Xiao, Hongping; Li, Xinhua. The article conveys some information:

Herein, authors prepared two terpyridine-containing Pd(II) complexes, [PdClL1]•solvent (A1) and [PdClL2]•2H2O (A2) (L1 = 4′-(4-carboxyl-phenyl)-2,2′:6′,2”-terpyridine, L2 = 2,6-bis(2-pyrazinyl)-4-(4-carboxyl-phenyl)pyridine), from 4′-(4-cyanophenyl)-2,2′:6′,2”-terpyridine (L1a)/2,6-bis(2-pyrazinyl)-4-(4-cyanophenyl)pyridine (L2a) and Pd(II) acetate and characterize them by several instrumental techniques. A1 and A2 are good catalysts for the coupling of 2-iodobiphenyl with iodobenzenes to afford triphenylenes, which is known to involve dual C-H bond activation and double C-C bond formation. The obtained data suggest that the mechanism of A1-and A2-mediated coupling may be similar to the reference Pd catalysts, A1 and A2 are also suitable catalysts for this cyclization process. Study on this kind of complexes is of importance to the development of novel Pd-based catalysts and triphenylene synthesis techniques. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Synthetic Route of C6H4ClI)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C6H4ClI

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 1774-47-6In 2021 ,《Synthesis of Pyrazolo[1,2-a]cinnolines via Rhodium(III)-Catalyzed [4+2] Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides》 appeared in Advanced Synthesis & Catalysis. The author of the article were Hu, Shulei; Han, Xu; Xie, Xiong; Fang, Feifei; Wang, Yong; Saidahmatov, Abdusaid; Liu, Hong; Wang, Jiang. The article conveys some information:

A method to synthesize pyrazolo[1,2-a]cinnolines via rhodium(III)-catalyzed C-H activation of pyrazolidinones and subsequent [4+2] annulation of sulfoxonium ylides was developed. 5-Substituted or 5,10-disubstituted pyrazolo[1,2-a]cinnolines could be obtained by slightly adjusting the reaction conditions. Gram-scale synthesis and practical transformations proved the practicability of this method. The mechanism of this method was proposed in the article on the basis of preliminary mechanistic results and previous reports. This method features simplified operation, metal-oxidant free, and readily available reactants. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

HPLC of Formula: 63069-48-7In 2021 ,《Cu(I)- and Au(I)-catalyzed regioselective oxidation of diynes: divergent synthesis of N-heterocycles》 appeared in Organic Chemistry Frontiers. The author of the article were Shen, Wen-Bo; Zhang, Ting-Ting; Zhang, Meng; Wu, Jing-Jing; Jiang, Xiao-Lei; Ru, Guang-Xin; Gao, Guang-Qin; Zhu, Xiu-Hong. The article conveys some information:

Catalyst-dependent oxidative cyclization of diynes 2-NH(C(O)R4)-4-R3C6H3CCCH2N(R2)CC(R1) [R1 = Ph, 2-phenylethenyl, thiophen-3-yl, etc.; R2 = Ts, Bs, Ms, benzenesulfonyl; R3 = H, Me, Cl, Br; R4 =Me, Ac, Bz, 4-fluorophenyl, etc.]/(R2)N(CH2CCR5)CCAr [R5 = Me, Et, pentyl, 3-phenylpropyl; Ar = Ph, 4-(trifluoromethyl)phenyl, 3,5-dichlorophenyl, etc.] with 3,5-dichloropyridine N-oxide is achieved using an amide directing group. Non-polarized and aminated alkyne could be selectively activated by copper and gold, thus leading to divergent synthesis of a range of pyrroles I and dihydroindeno[1,2-c]pyrrol-3(2H)-ones II (R6 = H, Cl, Me; R7 = H, Me, F, CF3, etc.; R8 = H, Cl, Me, etc.). It should be noted that this difference might be attributed to the multicoordinated Cu center and the linearly aligned dicoordinated Au center. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 1-Bromo-3-iodobenzeneIn 2019 ,《Shape-Persistent π-Conjugated Macrocycles with Aggregation-Induced Emission Property: Synthesis, Mechanofluorochromism, and Mercury(II) Detection》 was published in ACS Applied Materials & Interfaces. The article was written by Liu, Yi; Lin, Fa Xu; Feng, Yang; Liu, Xiaoqing; Wang, Lei; Yu, Zhen-Qiang; Tang, Ben Zhong. The article contains the following contents:

Shape-persistent conjugated macrocycles are fundamentally important because of their unique structure and properties. Herein, a series of π-conjugated macrocycles with a shape-persistent architecture, an adaptive backbone, and aggregation-induced emission (AIE) properties are synthesized via oxidative coupling of acetylene-terminated tetraphenylethylene precursor with a half-ring topol. and following transformation from butadiynylene linkers into thienylene ones. Characterization by NMR spectroscopy and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry provided unambiguous proofs for the macrocyclic structures. In particular, the free rotation of aromatic rings in the rigid macrocyclic backbone was validated by two-dimensional NMR spectroscopy, variable-temperature NMR measurements, and theor. calculations Moreover, these shape-persistent macrocyclic chromophores all exhibited obvious AIE phenomena and remarkable mechanofluorochromism behaviors with a red-shifted luminescence upon grinding and blue-shifted emission after solvent annealing. Also, the introduction of S atoms into the macrocyclic frameworks endowed the macrocyclic luminogen the capability to selectively detect mercury(II) ions in aqueous media among other metal ions. The experimental process involved the reaction of 1-Bromo-3-iodobenzene(cas: 591-18-4Quality Control of 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Quality Control of 1-Bromo-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2019 ,《A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides》 was published in Advanced Synthesis & Catalysis. The article was written by Chen, Lei; Liang, Jie; Chen, Zhen-yu; Chen, Jie; Yan, Ming; Zhang, Xue-jing. The article contains the following contents:

A convenient and efficient synthesis of sulfones RS(O)2R1 (R = Me, cyclopropyl, 4-methoxyphenyl, pyridin-3-yl, etc.; R1 = 4-cyanophenyl, pyridin-3-yl, pyrimidin-5-yl, etc.) from sulfinates RS(O)2Na and aryl halides R1X (X = Br, I, Cl) was developed. The reaction occurred under UV irradiation without transition metal catalyst or photocatalyst. A radical pathway via single-electron transfer (SET) of electron donor-acceptor (EDA) complex was proposed based on UV-vis spectroscopy, radical inhibiting and trapping experiments The experimental part of the paper was very detailed, including the reaction process of 4-Iodobenzaldehyde(cas: 15164-44-0Category: iodides-buliding-blocks)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Category: iodides-buliding-blocksIn 2021 ,《A novel approach for the detection and identification of sulfur mustard using liquid chromatography-electrospray ionization-tandem mass spectrometry based on its selective oxidation to sulfur mustard monoxide with N-iodosuccinimide》 was published in Journal of Mass Spectrometry. The article was written by Prihed, Hagit; Shifrovich, Avital; Shamai Yamin, Tamar; Madmon, Moran; Smolkin, Boris; Chen, Ravit; Blanca, Merav; Weissberg, Avi. The article contains the following contents:

A new derivatization strategy for the detection and identification of sulfur mustard (HD) via liquid chromatog.-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) is developed. The method incorporates selective oxidation of the sulfide group by the electrophilic iodine reagent N-iodosuccinimide (NIS) to produce sulfur mustard monoxide (HDSO). The derivatization reaction efficiencies were evaluated with acetonitrile extracts of soil, asphalt, cloth, Formica, and linoleum spiked with HD at concentrations of 50-5000 pg/mL and found to be similar to that with pure acetonitrile. The current derivatization approach is the first to preserve the identity of chloride groups and support HD regulation and evidentiary findings. In the part of experimental materials, we found many familiar compounds, such as 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Category: iodides-buliding-blocks)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Stimuli-Responsive Polycycles Based on Hetero-Buckybowl Trithiasumanene》 was written by Wang, Wenbo; Feng, Lijun; Hua, Xinqiang; Yuan, Chengshan; Shao, Xiangfeng. Recommanded Product: 15164-44-0This research focused ontrithiasumanene dioxide preparation photophys property sulfide ion detection; oxazolo fused trithiasumanene preparation oxidation photophys property; quinone trithiasumanene three component Dubus Radziszewski reaction aldehyde. The article conveys some information:

Herein, a series of hetero polycycles which show optical response toward chem. stimuli were synthesized from trithiasumanene (I, TTS). TTS is transformed into the ortho-quinone form II, which then undergoes three-component Debus-Radziszewski reaction with aldehydes RCHO (R = H, C6H5, 4-CH3C6H4, 4-IC6H4, Q) and ammonia to give oxazole-fused TTS III. The thiophene rings on III (R = C6H5, 4-CH3C6H4, 4-IC6H4) are selectively oxidized to thiophene-S,S-dioxides, affording IV. It was found that the electronic structures of these compounds III and IV are governed by the substituents on the oxazole moiety and oxidation state of the thiophene ring. Moreover, these hetero-polycycles exhibit optical responses toward different chem. stimuli. Particularly, compounds III (R = Q) and IV (R = C6H5) can serve as fluorescence detectors for harmful chem. sulfide ions (S2-/HS-) and aniline, resp. This work indicates that TTS is a promising precursor for the creation of responsive materials. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Synthesis and Characterization of Self-Assembled Chiral FeII2L3 Cages》 was published in Chemistry – A European Journal in 2018. These research results belong to Sun, Bin; Nurttila, Sandra S.; Reek, Joost N. H.. Product Details of 189518-78-3 The article mentions the following:

The authors present here the synthesis of chiral BINOL-derived (BINOL = 1,1′-bi-2-naphthol) bisamine and bispyridine-aldehyde building blocks that can be used for the self-assembly of novel chiral FeII2L3 cages when mixed with an Fe(II) precursor. The properties of chiral cages were studied by NMR and CD spectroscopy, cold-spray ionization MS, and mol. modeling. Upon formation of the M2L3 cages, the Fe corners can adopt various isomeric forms: mer, fac-Δ, or fac-Λ. The metal coordination geometry in R-Cages (1) and (2) were influenced by the chiral BINOL backbone to a limited extent, as a mixture of cages was formed with fac and mer configurations at the Fe corners. However, single cage species (fac-RR-Cage and fac-RS-Cage) that are enantiopure and highly sym. were obtained by generating these chiral M2L3 cages by using the bispyridine-aldehyde building blocks in combination with chiral amine moieties to form pyridylimine ligands for coordination to Fe. Next, consistent NMR spectra, the CD spectra confirm the configurations fac-(Λ,Λ) and fac-(Δ,Δ) corresponding to RR- and RS-Cage, resp. The experimental part of the paper was very detailed, including the reaction process of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3Product Details of 189518-78-3)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Product Details of 189518-78-3 Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Transmetalation Reactions Triggered by Electron Transfer between Organocopper Complexes》 was written by Lozano-Lavilla, Olmo; Gomez-Orellana, Pablo; Lledos, Agusti; Casares, Juan A.. COA of Formula: C7H5IOThis research focused ontransmetalation reaction triggered electron transfer organocopper complex. The article conveys some information:

[Cu(bipy)(C6F5)] reacts with most aryl iodides to form heterobiphenyls by cross-coupling, but when Rf-I is used (Rf = 3,5-dicholoro-2,4,6-trifluorophenyl), homocoupling products are also formed. Kinetic studies suggest that, for the homocoupling reaction, a mechanism based on transmetalation from [Cu(bipy)(C6F5)] to Cu(III) intermediates formed in the oxidative addition step is at work. D. functional theory calculations show that the interaction between these Cu(III) species and the starting Cu(I) complex involves a Cu(I)-Cu(III) electron transfer concerted with the formation of an iodine bridge between the metals and that a fast transmetalation takes place in a dimer in a triplet state between two Cu(II) units. In addition to this study using 4-Iodobenzaldehyde, there are many other studies that have used 4-Iodobenzaldehyde(cas: 15164-44-0COA of Formula: C7H5IO) was used in this study.

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.COA of Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Methyl, Trifluoromethyl, and Methoxycarbonyl-Introduction to the Fifth Position on the Pyridine Ring of Chloronicotinyl Insecticide Imidacloprid》 were Kagabu, Shinzo. And the article was published in Synthetic Communications in 2006. Name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine The author mentioned the following in the article:

Imidacloprid is the first (chloro)nicotine insecticide and is currently the largest-selling insecticide worldwide. As a project to find its variants of different insecticidal spectra, derivatives substituted with Me, trifluoromethyl, and methoxycarbonyl at the fifth position on the pyridine ring of imidacloprid were prepared In the experiment, the researchers used many compounds, for example, 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7Name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine)

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com