Month: October 2022

In 2016,Hu, Essa; Chen, Ning; Kunz, Roxanne K.; Hwang, Dah-Ren; Michelsen, Klaus; Davis, Carl; Ma, Ji; Shi, Jianxia; Lester-Zeiner, Dianna; Hungate, Randall; Treanor, James; Chen, Hang; Allen, Jennifer R. published 《Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies》.ACS Medicinal Chemistry Letters published the findings.Application of 301673-14-3 The information in the text is summarized as follows:

We report the discovery of PDE10A PET tracer AMG 580 developed to support proof of concept studies with PDE10A inhibitors in the clinic. To find a tracer with higher binding potential (BPND) in NHP than our previously reported tracer 1, we implemented a surface plasmon resonance assay to measure the binding off-rate to identify candidates with slower washout rate in vivo. Five candidates (2-6) from two structurally distinct scaffolds were identified that possessed both the in vitro characteristics that would favor central penetration and the structural features necessary for PET isotope radiolabeling. Two cinnolines (2, 3) and one keto-benzimidazole (5) exhibited PDE10A target specificity and brain uptake comparable to or better than 1 in the in vivo LC-MS/MS kinetics distribution study in SD rats. In NHP PET imaging study, [18F]-5 produced a significantly improved BPND of 3.1 and was nominated as PDE10A PET tracer clin. candidate for further studies. The experimental process involved the reaction of tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Kreyenschmidt, Anne-Kathrin; Bachmann, Sebastian; Niklas, Thomas; Stalke, Dietmar published 《Molecular Weight Estimation of Molecules Incorporating Heavier Elements from van-der-Waals Corrected ECC-DOSY》.ChemistrySelect published the findings.Application In Synthesis of 1,2-Diiodoethane The information in the text is summarized as follows:

Aggregate formation of organometallic compounds can be straightforwardly observed and interpreted through DOSY mol. weight (MW) estimation Recently, the power-law approach and preparation of external calibration curves (ECCs) has propelled the applicability of this DOSY MW estimation However, effective prediction of MWs of mols. containing heavier elements (e. g. halogenated compounds) has not been sufficiently accounted for. Hence, we introduce specialized ECCs for various halogenated mols. In an innovative attempt we propose a correction factor for standard ECCs that scales with mol. features to extend considerably the range of mols. that can be investigated by ECC-DOSY. The results came from multiple reactions, including the reaction of 1,2-Diiodoethane(cas: 624-73-7Application In Synthesis of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application In Synthesis of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,ChemistrySelect included an article by Ghasemzadeh, Maryam Sadat; Akhlaghinia, Batool. HPLC of Formula: 15164-44-0. The article was titled 《FMMWCNTs@CPA@SMTU@PdII NPs: As a Versatile Ferromagnetic Nanostructured Catalyst for Sonogashira-Hagihara Cross-Coupling Reaction in Solvent-Free Conditions》. The information in the text is summarized as follows:

This study deals with the designing and preparation of PdII immobilized on ferromagnetic multi-walled carbon nanotubes functionalized by aminated 2-chloroethylphosphonic acid with S-methylisothiourea (FMMWCNTs@CPA@SMTU@PdII NPs) as a versatile ferromagnetic nanostructured catalyst. The results show that FMMWCNTs@CPA@SMTU@PdII NPs with decorated MWCNTs by Fe3O4 NPs exhibited ferromagnetic properties with a uniform rod-like morphol. and particle sizes of about 20-30 nm. The catalytic performance of FMMWCNTs@CPA@SMTU@PdII NPs was evaluated in Sonogashira-Hagihara cross-coupling reaction at room temperature and in solvent-free conditions. Under appropriate condition, all reactions proceeded at a faster initial rate while exhibiting excellent activity and selectivity and the desired products were obtained in relatively excellent yields. In the experimental materials used by the author, we found 4-Iodobenzaldehyde(cas: 15164-44-0HPLC of Formula: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.HPLC of Formula: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic & Biomolecular Chemistry included an article by Li, Tongyu; Liu, Chang; Wu, Shaonan; Chen, Chen; Zhu, Bolin. Category: iodides-buliding-blocks. The article was titled 《Rhodium(III)-catalyzed unreactive C(sp3)-H alkenylation of N-alkyl-1H-pyrazoles with alkynes》. The information in the text is summarized as follows:

The first example of pyrazole-directed rhodium(III)-catalyzed unreactive C(sp3)-H alkenylation with alkynes has been described, which showed a relatively broad substrate scope with good functional group compatibility. Moreover, authors demonstrated that the transitive coordinating center pyrazole could be easily removed under mild conditions. In addition to this study using 1-Chloro-3-iodobenzene, there are many other studies that have used 1-Chloro-3-iodobenzene(cas: 625-99-0Category: iodides-buliding-blocks) was used in this study.

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Category: iodides-buliding-blocks Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Silver-Mediated Intermolecular Iodotrifluoromethoxylation of Alkenes》 was published in Journal of Organic Chemistry in 2020. These research results belong to Huang, Qingyun; Tang, Pingping. Reference of 1-Iodopyrrolidine-2,5-dione The article mentions the following:

For the first time, intermol. iodotrifluoromethoxylation between alkenes and NIS with AgF as the catalyst and TFMS as the trifluoromethoxylation reagent has been explored. The practical processes, good functional group tolerance, and easy scalability make this reaction an attractive protocol for the synthesis of trifluoromethoxylated iodides, which can be readily used for further synthetic manipulation. The experimental part of the paper was very detailed, including the reaction process of 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Reference of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Reference of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Accessing Dihydro-1,2-oxazine via Cloke-Wilson type Annulation of Cyclopropyl Carbonyls: Application towards the Diastereoselective Synthesis of Pyrrolo[1,2-b][1,2]oxazine》 was published in Journal of Organic Chemistry in 2020. These research results belong to Kumar, Pankaj; Kumar, Rakesh; Banerjee, Prabal. Safety of Trimethylsulfoxonium iodide The article mentions the following:

A convenient additive-free synthesis of dihydro-4H-1,2-oxazines via a Cloke-Wilson type ring expansion of the aryl substituted cyclopropane carbaldehydes (ACC) with the hydroxylamine salt was introduced. Comparatively less active cyclopropyl ketones also followed a similar protocol if supplemented by catalytic pTSA.H2O. The transformation was performed in an open-to-air flask as it showed negligible sensitivity towards air/moisture. Dihydro-4H-1,2-oxazines when subjected to cycloaddition with the cyclopropane diester, afforded a trouble-free formulation of the valued hexahydro-2H-pyrrolo[1,2-b][1,2]oxazine derivatives Cascade one-pot variant of this two-step strategy offered a comparable overall yield of the final product. In the experiment, the researchers used Trimethylsulfoxonium iodide(cas: 1774-47-6Safety of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Safety of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《C(sp2)-H Functionalization of Imidazole at the C2- and C4-Position via Palladium-Catalyzed Isocyanide Insertion Leading to Indeno[1,2-d]imidazole and Imidazo[1,2-a]indole Derivatives》 was written by Ren, Zhi-Lin; Cai, Shuang; Liu, Ying-Ying; Xie, Yin-Qing; Yuan, Ding; Lei, Min; He, Ping; Wang, Long. HPLC of Formula: 63069-48-7 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient strategy for the construction of fused imidazole derivatives through a palladium-catalyzed isocyanide insertion reaction has been accomplished. The methodol. provides an operationally simple and versatile route for the synthesis of indeno[1,2-d]imidazole and imidazo[1,2-a]indole skeletons which are rarely reported. The key features of the protocol are construction of sequential C-C/C-C/C-N bonds via C(sp2)-H functionalization of imidazole at the C2- and C4-position, resp. The compounds can be synthesized with diverse scaffolds, easily accessible starting materials, and moderate to good yields.4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7) was used in this study.

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I》 was written by Madhusudhan, Nikhil; Hu, Bin; Mishra, Prashant; Calva-Moreno, Jose F.; Patel, Khushbu; Boriack, Richard; Ready, Joseph M.; Nijhawan, Deepak. Application of 301673-14-3 And the article was included in ACS Chemical Biology in 2020. The article conveys some information:

Selective toxicity among cancer cells of the same lineage is a hallmark of targeted therapies. As such, identifying compounds that impair proliferation of a subset of non-small-cell lung cancer (NSCLC) cell lines represents one strategy to discover new drugs for lung cancer. Previously, phenotypic screens of 202 103 compounds led to the identification of 208 selective NSCLC toxins. The mechanism of action for the majority of these compounds remains unknown. Here, we discovered the target for a series of quinazoline diones (QDC) that demonstrate selective toxicity among 96 NSCLC lines. Using photoreactive probes, we found that the QDC binds to both mitochondrial complex I of the electron transport chain and hydroxyacyl CoA dehydrogenase subunit alpha (HADHA), which catalyzes long-chain fatty acid oxidation Inhibition of complex I is the on-target activity for QDC, while binding to HADHA is off-target. The sensitivity profile of the QDC across NSCLC lines correlated with the sensitivity profiles of six addnl. structurally distinct compounds The antiproliferative activity of these compounds is also the consequence of binding to mitochondrial complex I, reflecting significant structural diversity among complex I inhibitors. Small mols. targeting complex I are currently in clin. development for the treatment of cancer. Our results highlight complex I as a target in NSCLC and report structurally diverse scaffolds that inhibit complex I. After reading the article, we found that the author used tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Single-Electron Transfer from Dimsyl Anion in the Alkylation of Phenols》 was written by Rohe, Samantha; Revol, Guillaume; Marmin, Thomas; Barriault, Daniel; Barriault, Louis. Synthetic Route of C6H5IO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

While attempting to synthesize biaryl ethers we discovered the inadvertent formation of a methylsulfoxylmethyl ether byproduct. Formation of this unexpected byproduct presented an opportunity to streamline the synthesis of methylsulfoxylmethyl ethers. Mechanistic studies suggest a radical pathway with dimsyl potassium as a reducing agent. The experimental process involved the reaction of 3-Iodophenol(cas: 626-02-8Synthetic Route of C6H5IO)

3-Iodophenol(cas: 626-02-8) belongs to organic iodides.Synthetic Route of C6H5IO The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Liming; Xie, Henan; An, Guanghui; Li, Guangming published their research in Journal of Organic Chemistry in 2021. The article was titled 《Acid-Enabled Palladium-Catalyzed β-C(sp3)-H Functionalization of Weinreb Amides》.Recommanded Product: 15164-44-0 The article contains the following contents:

Herein, Pd(II)-catalyzed C(sp3)-H arylation and alkenylation of Weinreb amides was reported. A com. available, inexpensive sulfonic acid was employed to enhance the coordination of the catalyst with weak-coordinating substrates by increasing the electrophilicity of in situ formed palladium catalysts. The results came from multiple reactions, including the reaction of 4-Iodobenzaldehyde(cas: 15164-44-0Recommanded Product: 15164-44-0)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Recommanded Product: 15164-44-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com