Month: October 2022

《Detailed biodistribution of liposomes prepared with polyborane instead of cholesterol for BNCT: effects of PEGylation》 was written by Takeuchi, Issei; Ishizuka, Yukiko; Uchiro, Hiromi; Makino, Kimiko. Safety of 1,2-DiiodoethaneThis research focused ontumor antitumor boron neutron capture therapy liposome PEGylation. The article conveys some information:

Various drug delivery systems for boron neutron capture therapy (BNCT) have been developed. To selectively destroy cancer cells, the high accumulation and selective delivery of 10B into tumor tissue are required. In this study, a polyborane for BNCT with enhanced hydrophobicity was synthesized from decaborane as a boron carrier, and embedded into bare and PEGylated liposomes. These liposomes having diameters of 40-43 nm were injected into tail vein of tumor-bearing mice to evaluate their biodistribution. Boron concentrations in tumor and tumor/blood ratios of the liposomes were reached over 30 μg/g of tissue and over 5 at 8-24 h, resp. At 12 h after injection, PEGylated liposomes were found in tumor with high boron level (130.0 μg/g of tissue). This result showed that the PEGylated liposomes with a diameter of 40 nm were able to achieve efficient intratumoral 10B amount without replacing the 11B with 10B. In the experiment, the researchers used many compounds, for example, 1,2-Diiodoethane(cas: 624-73-7Safety of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Safety of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Product Details of 697300-79-1On May 6, 2004 ,《5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography》 appeared in Journal of Medicinal Chemistry. The author of the article were Zhang, Yi; Pavlova, Olga A.; Chefer, Svetlana I.; Hall, Andrew W.; Kurian, Varughese; Brown, LaVerne L.; Kimes, Alane S.; Mukhin, Alexey G.; Horti, Andrew G.. The article conveys some information:

Potential positron emission tomog. (PET) ligands with low picomolar affinity at the nicotinic acetylcholine receptor (nAChR) and with lipophilicity (log D) ranging from -1.6 to +1.5 have been synthesized. Most members of the series, which are derivatives of 5-substituted-6-halo-A-85380, exhibited a higher binding affinity at α4β2-nAChRs than epibatidine. An anal., by mol. modeling, revealed an important role of the orientation of the addnl. heterocyclic ring on the binding affinity of the ligands with nAChRs. The existing nicotinic pharmacophore models do not accommodate this finding. Two compounds of the series, 6-[18F]fluoro-5-(3-pyridinyl)-A-85380 (I) and 6-chloro-3-[[2-(S)-azetidinyl]methoxy]-5-[(2-[18F]fluoro-5-pyridinyl)pyridine], were radiolabeled with 18F. Comparison of PET data for [18F]-I and 2-[18F]FA shows the influence of lipophilicity on the binding potential. Recent PET studies with [18F]-I demonstrated that its binding potential values in Rhesus monkey brain were ca. 2.5 times those of 2-[18F]FA. Therefore, [18F]35 and several other members of the series, when radiolabeled, will be suitable for quant. imaging of extrathalamic nAChRs.2-Fluoro-5-iodopyrimidine(cas: 697300-79-1Product Details of 697300-79-1) was used in this study.

2-Fluoro-5-iodopyrimidine(cas: 697300-79-1) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 697300-79-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2015,Graff, Julien; Lastawiecka, Elzbieta; Guenee, Laure; Leroux, Frederic; Alexakis, Alexandre published 《Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands》.Advanced Synthesis & Catalysis published the findings.Application of 624-73-7 The information in the text is summarized as follows:

The desymmetrization of the prochiral tetrabromobiphenyl via asym. bromine-lithium exchange as a key step of synthesis of novel biphenyl-diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one- to three-step reactions in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Application of 624-73-7)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application of 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2017,Ito, Masahiro; Tanaka, Toshio; Cary, Douglas R.; Iwatani-Yoshihara, Misa; Kamada, Yusuke; Kawamoto, Tomohiro; Aparicio, Samuel; Nakanishi, Atsushi; Imaeda, Yasuhiro published 《Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors》.Journal of Medicinal Chemistry published the findings.Reference of 1,2-Diiodoethane The information in the text is summarized as follows:

Eukaryotic initiation factor 4A3 (eIF4A3), a member of the DEAD-box RNA helicase family, is one of the core components of the exon junction complex (EJC). The EJC is known to be involved in a variety of RNA metabolic processes typified by nonsense-mediated RNA decay (NMD). In order to identify mol. probes to investigate the functions and therapeutic relevance of eIF4A3, a search for selective eIF4A3 inhibitors was conducted. Through the chem. optimization of 1,4-diacylpiperazine derivatives identified via high-throughput screening (HTS), we discovered the first reported selective eIF4A3 inhibitor 53a exhibiting cellular NMD inhibitory activity. A surface plasmon resonance (SPR) biosensing assay ascertained the direct binding of 53a and its analog 52a to eIF4A3 and revealed that the binding occurs at a non-ATP binding site. Compounds 52a and 53a represent novel mol. probes for further study of eIF4A3, the EJC, and NMD. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diiodoethane(cas: 624-73-7Reference of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2018,Ali, Safaa H.; Deacon, Glen B.; Junk, Peter C.; Hamidi, Shima; Wiecko, Michal; Wang, Jun published 《Lanthanoid Pseudo-Grignard Reagents: A Major Untapped Resource》.Chemistry – A European Journal published the findings.Recommanded Product: 624-73-7 The information in the text is summarized as follows:

Pseudo-Grignard reagents PhLnI (Ln = Yb, Eu), readily prepared by the oxidative addition of iodobenzene to Yb or Eu metal at -78° in THF or 1,2-dimethoxyethane (DME), react with a range of bulky N,N’-bis(aryl)formamidines to generate an extensive series of LnII or more rarely LnIII complexes, [Eu(DippForm)I(THF)4]·THF (1), [{EuI2(dme)2}2] (2), [Eu(XylForm)I(dme)2]·0.5 dme (3a), [Eu(XylForm)I(dme)(μ-dme)]n (3b), [{Eu(XylForm)I(μ-OH)(THF)2}2] (4), [Yb(DippForm)I(THF)3]·THF (5 a), [Yb(DippForm)I2(THF)3]·2 THF (5 b), [{Yb(MesForm)I(THF)2}2] (6), [{Yb(XylForm)I(THF)2}2] (7a), and [Yb(XylForm)2I(dme)]·dme (7b) {Form = ArNCHNAr; XylForm (Ar = 2,6-Me2C6H3), MesForm (Ar = 2,4,6-Me3C6H2), DippForm (Ar = 2,6-iPr2C6H3)}. Reaction of PhEuI and MesFormH in DME consistently gave 2, and reaction with XylFormH in THF gave 4. Eu complexes 1 and 3a are seven-coordinate divalent monomers, while 3b is a seven-coordinate dme-bridged polymer. Complex 5a of the smaller YbII is a six-coordinate monomer, but the related 6 and 7a are six-coordinate iodide-bridged dimers. 4 Is a trivalent seven-coordinate hydroxide-bridged dimer, whereas complexes 5b and 7b are seven-coordinate monomeric YbIII derivatives A characteristic structural feature is that iodide ligands are cisoid to the formamidinate ligand. To illustrate the synthetic scope of the pseudo-Grignard reagents, [Yb(Ph2pz)I(THF)4] (Ph2pz = 3,5-diphenylpyrazolate) was oxidized with 1,2-diiodoethane to afford seven-coordinate monomeric pyrazolato-Yb(III) iodide [Yb(Ph2Pz)I2(THF)3] (8) in high yield, while metathesis between [Yb(Ph2pz)I(THF)4] and NaCp gave [Yb(C5H5)(Ph2pz)(THF)]n (9), a nine-coordinate η5:η5-Cp-bridged coordination polymer. Reaction of the pseudo-Grignard reagent MeYbI with KN(SiMe3)2 gave [K(dme)4][Yb{N(SiMe3)2}3] (10) with a charge-separated three-coordinate homoleptic [Yb{N(SiMe3)2}3]- anion, a complex that could be obtained in high yield by deliberate synthesis from YbI2 and KN(SiMe3)2 in DME. In addition to this study using 1,2-Diiodoethane, there are many other studies that have used 1,2-Diiodoethane(cas: 624-73-7Recommanded Product: 624-73-7) was used in this study.

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 624-73-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Zhi, Man-Ling; Chen, Bing-Zhi; Deng, Wei; Chu, Xue-Qiang; Loh, Teck-Peng; Shen, Zhi-Liang. Reference of 4-Iodobenzaldehyde. The article was titled 《Preparation of Alkyl Indium Reagents by Iodine-Catalyzed Direct Indium Insertion and Their Applications in Cross-Coupling Reactions》. The information in the text is summarized as follows:

Alkylindium reagents were generated in situ by direct metalation of primary alkyl iodides and bromides and cyclohexyl iodide with indium metal in the presence of iodine in THF (for alkyl iodides) or N,N-dimethylacetamide (for alkyl bromides). Palladium-catalyzed coupling of the alkylindium reagents with aryl iodides and selected aryl bromides and chlorides yielded arenes. In the experiment, the researchers used 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic & Biomolecular Chemistry included an article by Li, Hongfang; Li, Tao; Hsueh, Yu Jen; Wu, Xue; Xu, Feng; Zhang, Yong Jian. Recommanded Product: 90-14-2. The article was titled 《Tandem arylation and regioselective allylic etherification of 2,3-allenol via Pd/B cooperative catalysis》. The information in the text is summarized as follows:

An efficient method for the construction of arylated allylic ethers ArC(=CH2)CH(OR)CH2OH (Ar = Ph, 2H-1,3-benzodioxol-5-yl, thiophen-2-yl, etc.; R = Et, Bn, cyclohexylmethyl, furan-2-ylmethyl, etc.) was developed via three-component tandem arylation and allylic etherification of 2,3-allenol with aryl iodides ArI and alcs ROH. In the cooperative catalytic system of a palladium complex and triethylborane, the process allows rapid access to functionalized 1-arylvinylated 1,2-diol derivatives in good to high yields with complete branch-selectivities. The synthetic utility of the present process was demonstrated by the late-stage functionalization of a drug mol., the gram-scale synthesis and the elaboration of the products. In the experiment, the researchers used many compounds, for example, 1-Iodonaphthalene(cas: 90-14-2Recommanded Product: 90-14-2)

1-Iodonaphthalene(cas: 90-14-2) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Recommanded Product: 90-14-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Journal of Organic Chemistry included an article by Liu, Zhenwei; Luan, Nannan; Shen, Linhua; Li, Jingya; Zou, Dapeng; Wu, Yusheng; Wu, Yangjie. Application of 301673-14-3. The article was titled 《Palladium-Catalyzed Hiyama Cross-Couplings of Arylsilanes with 3-Iodoazetidine: Synthesis of 3-Arylazetidines》. The information in the text is summarized as follows:

The first palladium-catalyzed Hiyama cross-coupling reactions of arylsilanes with 3-iodoazetidine were described. The protocol provides a convenient access to a variety of useful 3-arylazetidines which are of great interest in pharmaceutical laboratories in moderate to good yields (30%-88%). In addition, this strategy has the advantage of easy operation and mild reaction conditions. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Application of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Oceanic alkyl iodides are believed to be the principal source of atmospheric iodine.Application of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Chemistry – A European Journal included an article by Hornum, Mick; Stendevad, Julie; Sharma, Pawan K.; Kumar, Pawan; Nielsen, Rasmus B.; Petersen, Michael; Nielsen, Poul. Safety of Trimethylsulfoxonium iodide. The article was titled 《Base-Pairing Properties of Double-Headed Nucleotides》. The information in the text is summarized as follows:

Nucleotides that contain two nucleobases (double-headed nucleotides) have the potential to condense the information of two sep. nucleotides into one. This presupposes that both bases must successfully pair with a cognate strand. Here, double-headed nucleotides that feature cytosine, guanine, thymine, adenine, hypoxanthine, and diaminopurine linked to the C2′-position of an arabinose scaffold were developed and examined in full detail. These monomeric units were efficiently prepared by convergent synthesis and incorporated into DNA oligonucleotides by means of the automated phosphoramidite method. Their pairing efficiency was assessed by UV-based melting-temperature anal. in several contexts and extensive mol. dynamics studies. Altogether, the results show that these double-headed nucleotides have a well-defined structure and invariably behave as functional dinucleotide mimics in DNA duplexes. In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Safety of Trimethylsulfoxonium iodide)

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.Safety of Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Materials Research Express included an article by Behrouzi, Leila; Bagheri, Robabeh; Song, Zhenlun; Kazemi, Foad; Kaboudin, Babak; Najafpour, Mohammad Mahdi. COA of Formula: C7H5IO. The article was titled 《Oxidation of alkylarenes by modified graphite》. The information in the text is summarized as follows:

Herein, an electrochem. method had introduced and developed for the selective benzylic oxidation of alkylarenes. This work utilized a simple redox mediator system, N-hydroxyphthalimide (NHPI), with an inexpensive and innovatory modified graphite and nickel-based electrode using undivided cell setups to the selective oxidation of alkylarenes toward the aldehyde and ketone production Since, the selective oxidation of alkylarenes toward aldehyde formation (in the aerobic conditions) was a prominent challenge, our method for alkylarenes oxidation with high yield and selectivity in the presence of oxygen under mild and metal free conditions was promising. In the experiment, the researchers used many compounds, for example, 4-Iodobenzaldehyde(cas: 15164-44-0COA of Formula: C7H5IO)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.COA of Formula: C7H5IO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com