Month: October 2022

Wang, Jian-Shu; Na, Yi; Ying, Jun; Wu, Xiao-Feng published an article in 2021. The article was titled 《Palladium-catalyzed 1,2-amino carbonylation of 1,3-dienes with (N-SO2Py)-2-iodoanilines: 2,3-dihydroquinolin-4(1H)-ones synthesis》, and you may find the article in Organic Chemistry Frontiers.HPLC of Formula: 63069-48-7 The information in the text is summarized as follows:

A palladium-catalyzed 1,2-amino carbonylation of 1,3-dienes with (N-SO2Py)-2-iodoanilines was developed for the construction of 2,3-dihydroquinolin-4(1H)-one scaffolds. Using benzene-1,3,5-triyl triformate (TFBen) as the CO source under the assistance of the N-SO2Py directing group, the reaction proceeded well to afford various 2,3-dihydroquinolin-4(1H)-ones in good yields (up to 88%). The effect of the directing groups was investigated and control experiments were performed to have a better understanding of the reaction pathway. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7HPLC of Formula: 63069-48-7)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 63069-48-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Du, Yijun; Gou, Faliang; Gao, Danning; Liu, Zhifeng; Shao, Linjun; Qi, Chenze published an article in 2021. The article was titled 《Palladium nanoparticles encapsulated in polyimide nanofibers: An efficient and recyclable catalyst for coupling reaction》, and you may find the article in Applied Organometallic Chemistry.Related Products of 15854-87-2 The information in the text is summarized as follows:

In this study, palladium-encapsulated poly(amic acid) (Pd@PAA) nanofibers were prepared by electrospinning, followed by thermal imidization to synthesize palladium-encapsulated polyimide (Pd@PI) nanofibers. SEM images confirmed the preparation of uniform and smooth Pd@PAA and Pd@PI nanofibers. Thermogravimetric anal. (TGA) results reveal that the Pd@PI nanofibers possessed excellent thermal stability. The dispersion of palladium nanoparticles in the polyimide nanofibers was characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The catalysis results show that this Pd@PI fibrous catalyst was very efficient to catalyze the cross-coupling reactions of aromatic iodides with Bu acrylate (Heck reaction) or phenylboronic acid derivatives (Suzuki reaction) to afford the desired products in good to excellent yields. Moreover, the Pd@PI catalyst could be easily separated and recovered from the reaction mixture by simple filtration due to the regular fibrous structure and reused for 10 times for both Heck and Suzuki reactions without obvious loss of its initial catalytic activity. Thus, the Pd@PI nanofiber catalyst holds great potential in chem. industry in terms of its excellent catalytic activity and stability. In the experiment, the researchers used 4-Iodopyridine(cas: 15854-87-2Related Products of 15854-87-2)

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.Related Products of 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wang, Yunsheng; Yang, Jie; Fang, Manman; Gong, Yanxiang; Ren, Jia; Tu, Liangjing; Tang, Ben Zhong; Li, Zhen published an article in 2021. The article was titled 《New Phenothiazine Derivatives That Exhibit Photoinduced Room-Temperature Phosphorescence》, and you may find the article in Advanced Functional Materials.Electric Literature of C6H4BrI The information in the text is summarized as follows:

The research of purely organic room-temperature phosphorescence (RTP) materials with stimulus response characteristic has drawn increasing attention for their broad application prospects. However, these kinds of materials are really scarce now, especially for those with efficient RTP emissions, which have largely limited their practical applications. Here, an all-around-type player in the field of photoinduced phosphorescence material appears, whose RTP efficiency can increase from near 0 to 22% after continuous UV irradiation Correspondingly, the UV-written patterns based on them can be clearly observed by the naked eye in daytime or even under sunlight. Moreover, these materials are found to show excellent photostability, and the strong RTP emission can still be observed after repeated activation for more than 50 times. The high RTP efficiency and good photostability make these photoinduced RTP materials exhibit an attractive prospect for potential applications in many fields, including leak test, microcrack detection, programmable information storage, and encryption. After reading the article, we found that the author used 1-Bromo-4-iodobenzene(cas: 589-87-7Electric Literature of C6H4BrI)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..Electric Literature of C6H4BrI It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shen, Yifeng; Xu, Congjun; Chen, Jie; Guan, Zilin; Huang, Yanjuan; Zeng, Zishan; Xu, Xiaoyu; Tan, Xiaomin; Zhao, Chunshun published an article in 2021. The article was titled 《Phototriggered Self-Adaptive Functionalized MOC-Based Drug Delivery Platform Promises High Antitumor Efficacy》, and you may find the article in Advanced Healthcare Materials.HPLC of Formula: 15854-87-2 The information in the text is summarized as follows:

Due to their great stability and special cavities, metal-organic cages (MOCs) are increasingly considered as promising nanocarriers for drug delivery. However, the size and surface dilemmas restrict their further biomedical applications. The ultrasmall size of MOCs facilitates tumor penetration but suffers from quick clearance and poor accumulation at the tumor site. Hydrophobicity of MOC surfaces improves internalization into tumor cells while causing low blood circulation time as well as poor biocompatibility. Therefore, it remains challenging for the MOC-based drug delivery nanoplatform to realize high therapeutic efficacy because it requires different or even opposite dimensions and surface characteristics in different steps of circulation, penetration, accumulation, and internalization processes. In this study, an unprecedented phototriggered self-adaptive platform (ZnPc@polySCage) is developed by integrating functionalized MOCs and a photodynamic therapy based reactive oxygen species responsive strategy to realize high-efficiency tumor-specific therapy. ZnPc@polySCage remains hydrophilic and stealthy during circulation, and retains its small original size for tumor penetration, while transforming to a larger size for effective accumulation and hydrophobic for enhanced internalization under laser irradiation in tumor tissue. With these essential transitions, ZnPc@polySCage demonstrates prominent antitumor effects. Overall, the work provides an advantageous strategy for functional MOC-based platforms and biomedical applications. In addition to this study using 4-Iodopyridine, there are many other studies that have used 4-Iodopyridine(cas: 15854-87-2HPLC of Formula: 15854-87-2) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists. 4-Iodopyridine is a halogenated heterocycle that is a building block for proteomics research.HPLC of Formula: 15854-87-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koteswaraiah, M.; Praveen, Ch; reddy, Thummaluru Veera; Raveendrareddy, Gopireddy; Srinivas, Uppalanchi published an article in 2022. The article was titled 《Design, synthesis and biological evaluation of aryl and hetero-aryl linked thieno[3,2-d]pyrimidine derivatives as anticancer agents》, and you may find the article in Chemical Data Collections.COA of Formula: C5H4IN The information in the text is summarized as follows:

A new library of different aryl and heteroaryl linked thieno[3,2-d]pyrimidine derivatives I [Ar = 4-MeC6H4, 4-MeOC6H4, 4-O2NC6H4, etc.] were synthesized and characterized by 1HNMR, 13CNMR and mass spectroscopic techniques. Further, these were evaluated for their anticancer potentials against the selected four human cancer cell lines including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and DU-145 (prostate cancer). The obtained results suggested that four compounds I [Ar = 3,4,5-tri-MeOC6H2, 3,5-di-MeOC6H3, 4-pyridyl, 4-pyrazyl] exhibited more potent anticancer properties. Predominantly, two compounds I [Ar = 3,4,5-tri-MeOC6H2, 4-pyridyl] demonstrated most capable anticancer activity of the library. In the experiment, the researchers used many compounds, for example, 4-Iodopyridine(cas: 15854-87-2COA of Formula: C5H4IN)

4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Yan, Songlin; Yu, Weijie; Zhang, Jianye; Fan, Hongmei; Lu, Zhifeng; Zhang, Zhenming; Wang, Tao published an article in Journal of Organic Chemistry. The title of the article was 《Access to gem-Difluoroalkenes via Organic Photoredox-Catalyzed gem-Difluoroallylation of Alkyl Iodides》.Formula: C10H18INO2 The author mentioned the following in the article:

An organic photoredox-catalyzed gem-difluoroallylation of α-trifluoromethyl alkenes CH2=CR(CF3) (R = Br, 4-bromophenyl, thiophen-3-yl, benzodioxol-5-yl, etc.) and 4-(trifluoromethyl)-1,2-dihydronaphthalene with alkyl iodides R1I (R1 = cyclohexyl, oxetan-3-yl, N-boc piperidin-4-yl, etc.) via C-F bond cleavage for the synthesis of gem-difluoroalkene derivatives RC(CH2R1)=CF2 and I is reported. This transition-metal-free transformation utilized a readily available organic dye 4CzIPN as the sole photocatalyst and employed a common chem. N,N,N’,N’-tetramethylethylenediamine as the radical activator of alkyl iodides via halogen-atom transfer. In addition, a variety of iodides, including primary, secondary, and tertiary alkyl iodides, were tolerated and provided good to high yields.tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Formula: C10H18INO2) was used in this study.

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C10H18INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Chen, Bo; Yu, Kai; Wu, Xiao-Feng published an article in Organic & Biomolecular Chemistry. The title of the article was 《Visible-light-induced defluorinative carbonylative coupling of alkyl iodides with α-trifluoromethyl substituted styrenes》.Product Details of 301673-14-3 The author mentioned the following in the article:

A visible-light-mediated defluorinative carbonylative cross-coupling of alkyl iodides RI (R = Me, cyclopentyl, N-Boc azetidin-3-yl, etc.) with α-trifluoromethyl styrenes R1C(=CH2)CF3 (R1 = 4-benzyloxyphenyl, 3-methylphenyl, 2-naphthyl, etc.) has been developed. The reaction occurs at room temperature under blue light irradiation, and various gem-difluoroalkenes R1C(CH2C(O)R)=CF2 were obtained in moderate to good yields. Synthetic transformations of the obtained product were performed as well. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3Product Details of 301673-14-3)

tert-Butyl 4-iodopiperidine-1-carboxylate(cas: 301673-14-3) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 301673-14-3

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2022,Wang, Can; Xiong, Qiu; Zhang, Zilong; Meng, Lingyi; Li, Feng; Yang, Longkai; Wang, Xiaobing; Zhou, Qin; Fan, Weihang; Liang, Lusheng; Lien, Shui-Yang; Li, Xin; Wu, Jihuai; Gao, Peng published an article in ACS Applied Materials & Interfaces. The title of the article was 《Deciphering the reduced loss in high fill factor inverted perovskite solar cells with methoxy-substituted poly(triarylamine) as the hole selective contact》.COA of Formula: C6H4BrI The author mentioned the following in the article:

A dopant-free polymeric hole selective contact (HSC) layer is ubiquitous for stable perovskite solar cells (PSCs). However, the intrinsic nonwetting nature of the polymeric HSC impedes the uniform spreading of the perovskite precursor solution, generating a terrible buried interface. Here, we dexterously tackle this dilemma from the perspective of dispersive and polar component surface energies of the HSC layer. A novel triarylamine-based HSC material, poly[bis(4-phenyl)(2,4-dimethoxyphenyl)amine] (2MeO-PTAA), was designed by introducing the polar methoxy groups to the para and ortho positions of the dangling benzene. These nonsym. substituted electron-donating methoxy groups enhanced the polar components of surface energy, allowing more tight interfacial contact between the HSC layer and perovskite and facilitating hole extraction When utilized as the dopant-free HSC layer in inverted PSCs, the 2MeO-PTAA-based device with CH3NH3PbI3 as the absorber exhibited an encouraging power conversion efficiency of 20.23% and a high fill factor of 84.31% with negligible hysteresis. Finally, a revised detailed balance model was used to verify the drastically lessened surface defect-induced recombination loss and shunt resistance loss in 2MeO-PTAA-based devices. This work demonstrates a facile and efficient way to modulate the buried interface and shed light on the direction to further improve the photovoltaic performance of inverted PSCs with other types of perovskites. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-4-iodobenzene(cas: 589-87-7COA of Formula: C6H4BrI)

1-Bromo-4-iodobenzene(cas: 589-87-7) is mainly used as the OLED pharmaceutical intermediate, as reagent for in situ desilylation and coupling of silylated alkynes, as substrate in copper-free Sonogashira coupling in aqueous acetone..COA of Formula: C6H4BrI It is also used in synthesis of β,β,dibromostyrenes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 1,2-DiiodoethaneIn 2021 ,《Cooperative Catalysis of Ru(III)-Porphyrin in CO2-Involved Synthesis of Oxazolidinones》 appeared in Chemistry – An Asian Journal. The author of the article were Chen, Xiao-Chao; Yao, Yin-Qing; Zhao, Kai-Chun; Liu, Lei; Lu, Yong; Liu, Ye. The article conveys some information:

Herein, a Ru(III)-porphyrin catalyst (RuCl3·3H2O-H2TPP) was found highly efficient in the three-component reaction of CO2, aliphatic amines and dichloroethane (or its derivative) for synthesis of oxazolidinones in the yields of 71∼91%. It was indicated by means of the control experiments and UV-vis spectra that CO2 was stoichiometrically activated by the involved aliphatic amine substrates to form a stable carbamate salt while 1,2-dichloroethane (or its derivative) was independently activated by the involved Ru(III)-porphyrin catalyst. The combination of CO2-activation by aliphatic amines with 1,2-dichloroethane activation by Ru(III)-porphyrin catalyst cooperatively contributed to this successful transformation. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diiodoethane(cas: 624-73-7Quality Control of 1,2-Diiodoethane)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Quality Control of 1,2-Diiodoethane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Recommanded Product: 4-IodopyridineIn 2022 ,《Synthesis and Mechanistic Investigation of Bipyrazolo[1,5-a]pyridines via Palladium-Catalyzed Cross-Dehydrogenative Coupling of Pyrazolo[1,5-a]pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Hsiao, Pu-Yen; Chang, Rong; Sue, Andrew C.-H.; Chu, Jean-Ho; Liao, Guan-Wei; Lee, Yi-Hsin; Huang, Jui-Yang. The article conveys some information:

The synthesis of a range of 3,3′-bipyrazolo[1,5-a]pyridine derivatives via direct cross-dehydrogenative coupling of pyrazolo[1,5-a]pyridine precursors was herein presented. This simple and efficient methodol. involving palladium(II)-catalyzed C-H bond activation showed good functional group tolerance and product yield (up to 94%). Through the mechanistic insights gained from both kinetic isotope effect exptl. studies and d. functional theory calculations, a plausible reaction mechanism was outlined. Furthermore, subsequent derivatizations of the resulting 7,7′-diaryl-3,3′-bipyrazolo[1,5-a]pyridines, executed by performing palladium-mediated ortho C-H bond activation followed by hypervalent iodine-induced chlorination, rendered this series of compounds more extended π-conjugation and twisted conformations. The study on these bipyrazolo[1,5-a]pyridine-based luminogens provided new opportunities for tailor-made organic luminescent materials.4-Iodopyridine(cas: 15854-87-2Recommanded Product: 4-Iodopyridine) was used in this study.

4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Recommanded Product: 4-Iodopyridine

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com