Month: October 2022

Sen, Chiranjit; Sahoo, Tapan; Singh, Harshvardhan; Suresh, Eringathodi; Ghosh, Subhash Chandra published the artcile< Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway>, Recommanded Product: Methyl 5-iodothiophene-2-carboxylate, the main research area is aminoquinoline amide sulfonamide carboxylation photocatalyst electron transfer pathway.

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives This methodol. uses in situ generated •CBr3 radical as a carboxylation agent with alc. and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent) (8-Aminoquinoline). 88105-22-0 belongs to class iodides-buliding-blocks, and the molecular formula is C6H5IO2S, Recommanded Product: Methyl 5-iodothiophene-2-carboxylate.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bao, Lipiao; Zhao, Baolin; Assebban, Mhamed; Halik, Marcus; Hauke, Frank; Hirsch, Andreas published the artcile< Covalent 2D Patterning, Local Electronic Structure and Polarization Switching of Graphene at the Nanometer Level>, Electric Literature of 1391728-13-4, the main research area is twodimensional patterning electronic structure polarization graphene; covalent patterning; fluorination; graphene; polarization switch; substitution.

A very facile and efficient protocol for the covalent patterning and properties tuning of graphene is reported. Highly reactive fluorine radicals were added to confined regions of graphene directed by laser writing on graphene coated with 1-fluoro-3,3-dimethylbenziodoxole. This process allows for the realization of exquisite patterns on graphene with resolutions down to 200 nm. The degree of functionalization, ranging from the unfunctionalized graphene to extremely high functionalized graphene, can be precisely tuned by controlling the laser irradiation time. Subsequent substitution of the initially patterned fluorine atoms afforded an unprecedented graphene nanostructure bearing thiophene groups. This substitution led to a complete switch of both the electronic structure and the polarization within the patterned graphene regions. This approach paves the way towards the precise modulation of the structure and properties of nanostructured graphene.

Chemistry – A European Journal published new progress about Electronic structure. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Electric Literature of 1391728-13-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Chenggui; Yang, Xinjun; Shang, Yong; Cheng, Hong-Gang; Yan, Wei; Zhou, Qianghui published the artcile< Synthesis of Benzofused Dioxabicycle Scaffolds via a Catellani Strategy>, Synthetic Route of 2265-92-1, the main research area is benzofused dioxabicycle preparation chemoselective regioselective; aryl iodide epoxide terminal alkyne Catellani reaction oxacyclization.

Reported is a modular strategy for the preparation of the unique benzofused dioxabicycle scaffolds involving a Catellani reaction of aryl iodides, epoxides, and terminal alkynes and an oxa-cyclization. This is a mild, scalable, chemoselective, and atom-economical protocol, compatible with various functionalized aryl iodides, epoxides, and terminal alkynes. With the ability to build up the mol. complexity rapidly and efficiently from feedstock chems., this method will have wide applications in organic synthesis.

Organic Letters published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Synthetic Route of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Poh, Jian-Siang; Garcia-Ruiz, Cristina; Zuniga, Andrea; Meroni, Francesca; Blakemore, David C.; Browne, Duncan L.; Ley, Steven V. published the artcile< Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation>, Recommanded Product: 4-Iodopyridin-3-ol, the main research area is trifluoromethyl nitrile oxide terminal alkyne cycloaddition; isoxazole trifluoromethyl regioselective preparation.

The preparation of a range of trifluoromethylated isoxazole building blocks through the cycloaddition reaction of trifluoromethyl nitrile oxide was reported. It was found that controlling the rate (and therefore concentration) of the formation of the trifluoromethyl nitrile oxide was Critical for the preferential formation of the desired isoxazole products vs. the furoxan dimer. Different conditions were optimized for both aryl- and alkyl-substituted alkynes. In addition, the reactivity at the isoxazole 4-position was briefly explored for these building blocks. Conditions for intermol. C-H arylation, lithiation and electrophile quench, and alkoxylation were all identified with brief substrate scoping that signifies useful tolerance to a range of functionalities. Finally, complementary processes for structural diversification through either intramol. cyclisation or intermol. cross-coupling were developed.

Organic & Biomolecular Chemistry published new progress about [3+2] Cycloaddition reaction (regioselective). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Recommanded Product: 4-Iodopyridin-3-ol.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Naghani, Farhad Fereydooni; Emamian, Saeedreza; Zare, Karim published the artcile< Exploring influence of fluorine substitution on the strength and nature of halogen bond between iodobenzene and hydrogen cyanide>, HPLC of Formula: 2265-92-1, the main research area is fluorine substituted iodobenzene hydrogencyanide strength halogen bond.

In the present study, the intermol. I … N halogen bond (XB) interaction between iodobenzene (IBZ) and its fluorinated derivatives (as Lewis acids LA 1 through LA 20) with HCN (as Lewis base LB) is theor. explored to shed light on the electronic nature and strength of the mentioned non-covalent interaction (NCI). The hydrogen atoms of Ph ring in IBZ were substituted by fluorine atom to probe different impacts of this atom. Such a substitution is paid attention from the number as well as the position of fluorine atoms points of view. Our analyses reveal that this XB interaction whose interaction energy spans a narrow range between 1.0 and 3.0 kcal·mol-1 should be classified as a weak NCI. The symmetry-adapted perturbation theory (SAPT) anal. evidences that the I … N XB in the investigated binary complexes (BCs) is mainly dominated by electrostatic and dispersion interactions, and, in the meantime, induction interactions can safely be ignored. Among the many I … N XB descriptors, Vs,max, which corresponds to the most pos. value of electrostatic potential computed for the iodine atom in LAs, plays a key role. Indeed, such an easily and rapidly computable quantity (Vs,max) allows a sufficiently accurate prediction of interaction energy together with SAPT-derived components anal. to become feasible by a simple inclusion of Vs,max value within the numerous explored estimators. Although the strength of I … N XB interaction in the studied BCs is increased by an increase in the number of fluorine substituent, the position of fluorine atom cannot significantly alter the strength of the mentioned interaction.

Journal of Physical Organic Chemistry published new progress about Bader electron density. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, HPLC of Formula: 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Jankiewicz, Bartlomiej J.; Gao, Jinshan; Reece, Jennifer N.; Vinueza, Nelson R.; Narra, Padmaja; Nash, John J.; Kenttamaa, Hilkka I. published the artcile< Substituent Effects on the Nonradical Reactivity of 4-Dehydropyridinium Cation>, Category: iodides-buliding-blocks, the main research area is substituent effect nonradical reactivity dehydropyridinium cation.

Recent studies have shown that the reactivity of the 4-dehydropyridinium cation significantly differs from the reactivities of its isomers toward THF. While only hydrogen atom abstraction was observed for the 2- and 3-dehydropyridinium cations, nonradical reactions were observed for the 4-isomer. In order to learn more about these reactions, the gas-phase reactivities of the 4-dehydropyridinium cation and several of its derivatives toward THF were investigated in a Fourier transform ion electron resonance mass spectrometer. Both radical and nonradical reactions were observed for most of these pos. charged radicals. The major parameter determining whether nonradical reactions occur was found to be the electron affinity of the radicals-only those with relatively high electron affinities underwent nonradical reactions. The reactivities of the monoradicals are also affected by hydrogen bonding and steric effects.

Journal of Physical Chemistry A published new progress about Ab initio methods (G3MP2B3). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Category: iodides-buliding-blocks.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Smith, Garry R.; Brenneman, Douglas E.; Zhang, Yan; Du, Yanming; Reitz, Allen B. published the artcile< Small-Molecule Anticonvulsant Agents with Potent In Vitro Neuroprotection and Favorable Drug-Like Properties>, Synthetic Route of 2265-92-1, the main research area is difluoroethylsulfamide anticonvulsant neuroprotectant central nervous system pharmacokinetics pharmacodynamics.

Severe seizure activity is associated with reoccurring cycles of excitotoxicity and oxidative stress that result in progressive neuronal damage and death. Intervention with these pathol. processes is a compelling disease-modifying strategy for the treatment of seizure disorders. We have optimized a series of small mols. for neuroprotective and anticonvulsant activity as well as altered their phys. properties to address potential metabolic liabilities, to improve CNS penetration, and to prolong the duration of action in vivo. Utilizing phenotypic screening of hippocampal cultures with nutrient medium depleted of antioxidants as a disease model, cell death and decreased neuronal viability produced by acute treatment with glutamate or hydrogen peroxide were prevented. Modifications to our previously reported proof of concept compounds have resulted in a lead which has full neuroprotective action at <1 nM and antiseizure activity across six animal models including the kindled rat and displays excellent pharmacokinetics including high exposure to the brain. These modifications have also eliminated the requirement for a chiral mol., removing the possibility of racemization and making large-scale synthesis more easily accessible. These studies strengthen our earlier findings which indicate that potent, multifunctional neuroprotective anticonvulsants are feasible within a single mol. entity which also possesses favorable CNS-active drug properties in vitro and in vivo. Journal of Molecular Neuroscience published new progress about Anticonvulsants. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Synthetic Route of 2265-92-1.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pan, Cheng; Wang, Limin; Han, Jianwei published the artcile< Palladium-Catalyzed Site-Selective Benzocylization of Aromatic Acids with o-Fluoro-Substituted Diaryliodonium Salts toward 3,4-Benzocoumarins>, Formula: C6H3F2I, the main research area is benzocoumarin preparation palladium catalyzed site selective benzocyclization; benzocyclization aromatic acid fluoro substituted diaryliodonium salt.

By using 2-fluoro-substituted diaryliodonium salts, a novel benzocylization has been accomplished for the synthesis of 3,4-benzocoumarin derivatives via a cascade of ortho-arylation and defluorination in the presence of palladium catalysts. The reaction exhibits a broad compatibility of readily available aromatic acids with an excellent level of site-selectivity. Mechanistic investigations revealed a unique reactivity of carboxylic acid directed arylation by followed nucleophilic substitution of aromatic fluoride in the present system.

Organic Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Formula: C6H3F2I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Miller, Eric M.; Walczak, Maciej A. published the artcile< Light-Mediated Cross-Coupling of Anomeric Trifluoroborates>, Product Details of C6H3F2I, the main research area is BMIDA ester deoxy sugar disaccharide fluoroborate glycosylation; light mediated cross coupling anomeric fluoroborate stereoselective arylation etherification.

Stereoselective reactions at the anomeric carbon constitute the cornerstone of preparative carbohydrate chem. Here, we report stereoselective C-arylation and etherification reactions of anomeric trifluoroborates derived from BMIDA esters. These reactions are characterized by high anomeric selectivities for 2-deoxysugars and broad substrate scope (24 examples), including disaccharides and trifluoroborates with free hydroxyl groups. Taken together, this new class of carbohydrate reagents adds the palette of anomeric nucleophile reagents suitable for efficient installation of C-C bonds.

Organic Letters published new progress about Arylation catalysts, stereoselective. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Product Details of C6H3F2I.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com