Month: October 2022

Formula: C6H5ClINIn 2021 ,《Palladium-Catalyzed Carbonylative Synthesis of 2-(Trifluoromethyl)quinazolin-4(3H)-ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds》 appeared in Advanced Synthesis & Catalysis. The author of the article were Wang, Le-Cheng; Zhang, Yu; Chen, Zhengkai; Wu, Xiao-Feng. The article conveys some information:

A procedure on palladium-catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones has been achieved. In this transformation, Mo(CO)6 has been used both as a convenient CO source and a reducing reagent. This newly developed protocol is compatible with various nitro compounds and can be readily scaled up to 1 mmol scale. In the part of experimental materials, we found many familiar compounds, such as 4-Chloro-2-iodoaniline(cas: 63069-48-7Formula: C6H5ClIN)

4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C6H5ClIN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

SDS of cas: 1774-47-6In 2021 ,《Rhodium(III)-Catalyzed Cross-Coupling of Sulfoxonium Ylides with Quinoline-8-carboxaldehydes for Synthesis of Quinoline-1,3-diketones》 appeared in Asian Journal of Organic Chemistry. The author of the article were Lyu, Xue-Li; Huang, Shi-Sheng; Huang, Yuan-Qiong; Song, Hong-Jian; Liu, Yu-Xiu; Li, Yong-Qiang; Yang, Shao-Xiang; Wang, Qing-Min. The article conveys some information:

Herein, a protocol for rhodium(III)-catalyzed aldehydic C(sp2)-H acylmethylation reactions of quinoline-8-carboxaldehydes I (R = H, 6-(4-methoxyphenyl), 5-(naphthalen-1-yl), etc.) using sulfoxonium ylides R1C(O)CH=S(O)Me2 (R1 = Ph, propan-2-yl, adamantan-1-yl, etc.) as carbene precursors to afford 1,3-diketones II, which readily tautomerized to their enol forms was reported. The reaction mechanism was determined by synthesizing the key intermediate, a five-membered-ring acylrhodium species were determinedTrimethylsulfoxonium iodide(cas: 1774-47-6SDS of cas: 1774-47-6) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides. Further, it reacts with alfa,beta-unsaturated esters to get cyclopropyl esters.SDS of cas: 1774-47-6

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Quality Control of 1-Iodopyrrolidine-2,5-dioneIn 2019 ,《Influence of remote functional groups towards the formation of 1,2-cis glycosides: special emphasis on β-mannosylation》 appeared in Organic & Biomolecular Chemistry. The author of the article were Gucchait, Arin; Misra, Anup Kumar. The article conveys some information:

A convenient straightforward method has been developed for 1,2-cis glycosylation and β-mannosylation in excellent yields using glycosyl donors having a 4,6-O-benzylidene acetal together with a p-methoxybenzyl (PMB) or 2-naphthylmethyl (NAP) group at the C-3 position under standard glycosylation conditions. After reading the article, we found that the author used 1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Quality Control of 1-Iodopyrrolidine-2,5-dione)

1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Quality Control of 1-Iodopyrrolidine-2,5-dione

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Oxidation Mechanisms of the UV/Free Chlorine Process: Kinetic Modeling and Quantitative Structure Activity Relationships》 was written by Zhou, Shiqing; Zhang, Weiqiu; Sun, Julong; Zhu, Shumin; Li, Ke; Meng, Xiaoyang; Luo, Jinming; Shi, Zhou; Zhou, Dandan; Crittenden, John C.. Product Details of 88-67-5This research focused onwastewater oxidation UV chlorine kinetics model. The article conveys some information:

Recently, the UV/free chlorine process has gained attention as a promising technol. for destroying refractory organic contaminants in the aqueous phase. We have developed a kinetic model based on first-principles to describe the kinetics and mechanisms of the oxidation of organic contaminants in the UV/free chlorine process. Substituted benzoic acid compounds (SBACs) were chosen as the target parent contaminants. We determined the second-order rate constants between SBACs and reactive chlorine species (RCS; including Cl·, Cl-2· and ClO·) by fitting our model to the exptl. results. We then predicted the concentration profiles of SBACs under various operational conditions. We analyzed the kinetic data and predicted concentration profiles of reactive radicals (HO· and RCS), we found that ClO· was the dominant radicals for SBACs destruction. In addition, we established quant. structure activity relationships (QSARs) that can help predict the second-order rate constants for SBACs destruction by each type of reactive radicals using SBACs Hammett constants Our first-principles-based kinetic model has been verified using exptl. data. Our model can facilitate a design for the most cost-effective application of the UV/free chlorine process. For example, our model can determine the optimum chlorine dosage and UV light intensity that result in the lowest energy consumption. The experimental part of the paper was very detailed, including the reaction process of 2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Product Details of 88-67-5

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Visible-Light-Mediated Difunctionalization of Alkynes: Synthesis of β-Substituted Vinylsulfones Using O- and S-Centered Nucleophiles》 was written by Sahoo, Ashish Kumar; Dahiya, Anjali; Das, Bubul; Behera, Ahalya; Patel, Bhisma K.. SDS of cas: 88-67-5This research focused onvinyl sulfone preparation regioselective diastereoselective green chem; alkyne sulfinate nucleophile sulfonylation photocatalyst. The article conveys some information:

A series of Z-β-substituted vinylsulfones (Z)-R1C(R3C(O)O)=CHS(O)2R2 (R1 = Ph, cyclohexyl, 4-bromophenyl, etc.; R2 = Me, 4-methylphenyl, thiophen-2-yl, etc.; R3 = acetyl, stearyl, cyclopropylmethyl, etc.) (I) was prepared via a green-light-induced, regioselective difunctionalization of terminal alkyne R1C6H4CCH has been disclosed using sodium arylsulfinates R2S(O)2Na and carboxylic acids R3C(O)OH in the presence of eosin Y as the photocatalyst. The present methodol. is further demonstrated by employing NH4SCN as S-centered nucleophile instead of carboxylic acid. The mechanistic investigation reveals a radical-induced iodosulfonylation followed by a base-mediated nucleophilic substitution. The mechanism is supported by various studies viz., radical-trapping experiment, fluorescence quenching and CV studies. In this protocol, Z-β-substituted vinylsulfones (I) and (Z)-R4C6H4C(R5)=C(R6)S(O)2R7 (R4 = H, 3-Me, 4-Me, 4-tert-butyl; R5 = I, SCN; R6 = H, methyl; R7 = Ph, 4-methylphenyl) are obtained exclusively covering a broad range of alkynes and nucleophiles which are often unaddressed. The present strategy can tolerate structurally discrete substrates with steric bulk and different electronic properties, which provides a straightforward and practical pathway for the synthesis of highly functionalized Z-β-substituted vinylsulfones. Herein, C-O and C-S bonds are assembled simultaneously with the concomitant introduction of important functional groups viz. ester, thiocyanate, and sulfone. The experimental process involved the reaction of 2-Iodobenzoic acid(cas: 88-67-5SDS of cas: 88-67-5)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.SDS of cas: 88-67-5Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

COA of Formula: C6H3ClINO2On October 31, 2007 ,《Applicability aspects of transition metal-catalyzed aromatic amination protocols in medicinal chemistry》 appeared in Advanced Synthesis & Catalysis. The author of the article were Tasler, Stefan; Mies, Jan; Lang, Martin. The article conveys some information:

The application of palladium- and copper-catalyzed reactions for the aromatic amination of pharmacol. relevant scaffolds is investigated. The focus is set on the scope of several protocols for the introduction of amines of broad structural diversity, allowing for the synthesis of numerous derivatives of one biol. hit structure for screening in biol. assay systems. Thus, attaining optimized yields and TONs had not a major priority, most important were practical aspects, that is no further purification and drying of reagents and solvents had to be envisaged, ideally only a few transition metal-based protocols had to be applied for synthesizing structurally diverse compounds in sufficient amounts (several milligrams) for screening without any fine-tuning of conditions and catalytic systems. After reading the article, we found that the author used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3COA of Formula: C6H3ClINO2)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides.COA of Formula: C6H3ClINO2 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Bayeh, Liela; Le, Phong Q.; Tambar, Uttam K. published an article in Nature (London, United Kingdom). The title of the article was 《Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block》.Recommanded Product: (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene The author mentioned the following in the article:

The stereoselective oxidation of hydrocarbons is one of the most notable advances in synthetic chem. over the past fifty years. Inspired by nature, enantioselective dihydroxylations, epoxidations and other oxidations of unsaturated hydrocarbons have been developed. More recently, the catalytic enantioselective allylic carbon-hydrogen oxidation of alkenes has streamlined the production of pharmaceuticals, natural products, fine chems. and other functional materials. Allylic functionalization provides a direct path to chiral building blocks with a newly formed stereocenter from petrochem. feedstocks while preserving the olefin functionality as a handle for further chem. elaboration. Various metal-based catalysts have been discovered for the enantioselective allylic carbon-hydrogen oxidation of simple alkenes with cyclic or terminal double bonds. However, a general and selective allylic oxidation using the more common internal alkenes remains elusive. Here we report the enantioselective, regioselective and E/Z-selective allylic oxidation of unactivated internal alkenes via a catalytic hetero-ene reaction with a chalcogen-based oxidant [e.g., I + sulfurimide PhSO2N:S:O → II (68% yield, 96:4 er, > 20:1 rr) in presence of SbCl5 and a chiral BINOL derivative]. Our method enables non-sym. internal alkenes to be selectively converted into allylic functionalized products with high stereoselectivity and regioselectivity. Stereospecific transformations of the resulting multifunctional chiral building blocks highlight the potential for rapidly converting internal alkenes into a broad range of enantioenriched structures that can be used in the synthesis of complex target mols. The experimental process involved the reaction of (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3Recommanded Product: (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene)

(R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthalene(cas: 189518-78-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Recommanded Product: (R)-3,3′-Diiodo-2,2′-bis(methoxymethoxy)-1,1′-binaphthaleneHalogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com