Month: October 2022

de Jesus Cortez, Felipe; Nguyen, Phuong; Truillet, Charles; Tian, Boxue; Kuchenbecker, Kristopher M.; Evans, Michael J.; Webb, Paul; Jacobson, Matthew P.; Fletterick, Robert J.; England, Pamela M. published their research in ACS Chemical Biology on December 15 ,2017. The article was titled 《Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen》.SDS of cas: 887707-25-7 The article contains the following contents:

Resistance to clin. antiandrogens has plagued the evolution of effective therapeutics for advanced prostate cancer. As with the first-line therapeutic bicalutamide (Casodex), resistance to newer antiandrogens (enzalutamide, ARN-509) develops quickly in patients, despite the fact that these drugs have ∼10-fold better affinity for androgen receptor than bicalutamide. Improving affinity alone is often not sufficient to prevent resistance and alternative strategies are needed to improve antiandrogen efficacy. Covalent and reversible covalent drugs are being used to thwart drug resistance in other contexts, and activated aryl nitriles are among the moieties being exploited for this purpose. The authors capitalized on the presence of an aryl nitrile in bicalutamide, and the existence of a native cysteine residue (Cys784) in the androgen receptor ligand binding pocket, to develop 5N-bicalutamide I, a cysteine-reactive antiandrogen. I exhibits a 150-fold improvement in Ki and 20-fold improvement in IC50 over the parent compound The authors attribute the marked improvement in affinity and activity to the formation of a covalent adduct with Cys784, a residue that is not among the more than 160 androgen receptor point mutations associated with prostate cancer. Increasing the residence time of bound antiandrogen via formation of a covalent adduct may forestall the drug resistance seen with current clin. antiandrogens. After reading the article, we found that the author used 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7SDS of cas: 887707-25-7)

2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.SDS of cas: 887707-25-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Jing-Bo; Li, Feng-Yun; Dong, Jing-Yue; Li, Yu-Xin; Zhang, Xiu-Lan; Wang, Yuan-Hong; Xiong, Li-Xia; Li, Zheng-Ming published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Anthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship》.Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene The author mentioned the following in the article:

A series of novel anthranilic diamides derivatives (7a-s) containing halogen, trifluoromethyl group and cyano group were designed, synthesized, and characterized by m.p., 1H NMR, 13C NMR and elemental analyses. The bioactivity revealed that most of them showed moderate to excellent activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). Above all, the larvicidal activity of I against oriental armyworm was 100% and 40% at 0.25 and 0.1 mg L-1, comparable to that of the standard chlorantraniliprole (100%, 0.25 mg L-1 and 20%, 0.1 mg L-1). What is more, 7o against diamondback moth displayed 90% insecticidal activity at 0.01 mg L-1, superior to chlorantraniliprole (45%, 0.01 mg L-1). The experiments I on the American cockroach (Periplaneta Americana) heart beating rates (Dorsal vessel) and contractile force were compared with chlorantraniliprole. In addition, I could affect the calcium homeostasis in the central neurons of the third larvae of oriental armyworm, which revealed that the ryanodine receptor is the potential target of I. The d. functional theory (DFT) calculation results revealed the amide bridge, the benzene ring of anthraniloyl moiety and pyrazole ring might play an important role in the insecticidal activity through hydrophobic interactions and π-π conjugations. In the experimental materials used by the author, we found 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene)

1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides.Recommanded Product: 1-Chloro-4-iodo-2-nitrobenzene The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The author of 《Synthesis of trifluoromethylthiolated pyridinones through the copper-mediated trifluoromethylthiolation of iodopyridinones》 were Luo, Beibei; Zhang, Yunxiao; You, Yi; Weng, Zhiqiang. And the article was published in Organic & Biomolecular Chemistry in 2016. Synthetic Route of C6H6INO The author mentioned the following in the article:

An operationally simple method for the copper-mediated trifluoromethylthiolation of iodopyridinones employing (bpy)CuSCF3 (bpy = 2,2′-bipyridine) as a trifluoromethylthiolating reagent was presented. Various types of iodopyridinones were applicable and the trifluoromethylthiolated pyridinones were obtained in moderate to excellent yields. This method tolerated a variety of protecting groups on the nitrogen atom of pyridinones. In addition, scalability of the reaction was demonstrated. The results came from multiple reactions, including the reaction of 4-Iodo-1-methylpyridin-2(1H)-one(cas: 889865-47-8Synthetic Route of C6H6INO)

4-Iodo-1-methylpyridin-2(1H)-one(cas: 889865-47-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C6H6INO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2016,Nakayama, Yasuaki; Maeda, Yuichiro; Kotatsu, Masayuki; Sekiya, Ruriko; Ichiki, Masato; Sato, Takaaki; Chida, Noritaka published 《Enantioselective Total Synthesis of (+)-Neostenine》.Chemistry – A European Journal published the findings.Formula: C2H4I2 The information in the text is summarized as follows:

A chirality transfer approach using acyclic polyol intermediates for the synthesis of (+)-neostenine (1, I) has been developed. The sequential Overman/Claisen rearrangement of an allylic 1,2-diol was especially useful, installing two contiguous stereocenters with complete diastereoselectivity in a one-pot sequence. The SmI2-mediated cyclization and the subsequent chemoselective reduction of a lactam moiety accomplished the first enantioselective total synthesis of (+)-neostenine (1). In the experimental materials used by the author, we found 1,2-Diiodoethane(cas: 624-73-7Formula: C2H4I2)

1,2-Diiodoethane(cas: 624-73-7) is one of organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C2H4I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Advanced Materials (Weinheim, Germany) included an article by Xu, Yuwei; Liang, Xiaoming; Zhou, Xuehong; Yuan, Peisen; Zhou, Jiadong; Wang, Cong; Li, Binbin; Hu, Dehua; Qiao, Xianfeng; Jiang, Xiaofang; Liu, Linlin; Su, Shi-Jian; Ma, Dongge; Ma, Yuguang. Name: 1-Bromo-3-iodobenzene. The article was titled 《Highly Efficient Blue Fluorescent OLEDs Based on Upper Level Triplet-Singlet Intersystem Crossing》. The information in the text is summarized as follows:

Purely organic electroluminescent materials, such as thermally activated delayed fluorescent (TADF) and triplet-triplet annihilation (TTA) materials, basically harness triplet excitons from the lowest triplet excited state (T1) to realize high efficiency. Here, a fluorescent material that can convert triplet excitons into singlet excitons from the high-lying excited state (T2), referred to here as a “”hot exciton”” path, is reported. The energy levels of this compound are determined from the sensitization and nanosecond transient absorption spectroscopy measurements, i.e., small splitting energy between S1 and T2 and rather large T2-T1 energy gap, which are expected to impede the internal conversion (IC) from T2 to T1 and facilitate the reverse intersystem crossing from the high-lying triplet state (hRISC). Through sensitizing the T2 state with ketones, the existence of the hRISC process with an ns-scale delayed lifetime is confirmed. Benefiting from this fast triplet-singlet conversion, the nondoped device based on this “”hot exciton”” material reaches a maximum external quantum efficiency exceeding 10%, with a small efficiency roll-off and CIE coordinates of (0.15, 0.13). These results reveal that the “”hot exciton”” path is a promising way to exploit high efficient, stable fluorescent emitters, especially for the pure-blue and deep-blue fluorescent organic light-emitting devices. After reading the article, we found that the author used 1-Bromo-3-iodobenzene(cas: 591-18-4Name: 1-Bromo-3-iodobenzene)

1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Name: 1-Bromo-3-iodobenzene Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In 2019,Organic & Biomolecular Chemistry included an article by Pan, Yingying; Gong, Yuxin; Song, Yanhong; Tong, Weiqi; Gong, Hegui. Reference of 4-Iodobenzaldehyde. The article was titled 《Deoxygenative cross-electrophile coupling of benzyl chloroformates with aryl iodides》. The information in the text is summarized as follows:

This work describes Ni-catalyzed cross-electrophile coupling of benzyl chloroformate derivatives R1CH(R2)OC(O)Cl (R1 = C6H5, 4-FC6H4, 3-CH3C6H4, etc.; R2 = H, Me, butyl) with aryl iodides ArI (Ar = biphenyl-4-yl, naphthalen-1-yl, 3-oxo-2,3-dihydro-1H-inden-5-yl, 1-benzothiophen-5-yl, etc.) that generates a wide range of diaryl methane products R1CH(R2)Ar. The mild reaction conditions merit the C-O bond radical fragmentation of benzyl chloroformates via halide abstraction or a single electron reduction by a Ni catalyst. This work offers a new substrate type for cross-electrophile couplings. In the part of experimental materials, we found many familiar compounds, such as 4-Iodobenzaldehyde(cas: 15164-44-0Reference of 4-Iodobenzaldehyde)

4-Iodobenzaldehyde(cas: 15164-44-0) is used in synthesis of 4-[2-(trimethylsilyl)ethynyl]benzaldehyde, 5,15-dimesityl-10-(3-[2-(trimethylsilyl)ethynyi]phenyl}-20-(4-iodophenyl)porphyrin, and 5,15-dimesityl-10-[3,5-bis{2-[4-(N,N’-difluoroboryl-1,9-dimethyidipyrrin-5-yl)-phenyl]ethynyl}phenyl]-20-(4-iodophenyl)porphyrin.Reference of 4-Iodobenzaldehyde

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Photochemical Functionalization of Heterocycles with EBX Reagents: C-H Alkynylation versus Deconstructive Ring Cleavage》 was published in Chemistry – A European Journal in 2020. These research results belong to Voutyritsa, Errika; Garreau, Marion; Kokotou, Maroula G.; Triandafillidi, Ierasia; Waser, Jerome; Kokotos, Christoforos G.. COA of Formula: C7H5IO2 The article mentions the following:

Herein, a cheap and efficient photochem. method for the C-H functionalization of saturated O-heterocycles, as well as the deconstructive ring-cleavage of S-heterocycles, employing hypervalent iodine alkynylation reagents (ethynylbenziodoxolones, EBX) were reported. This photochem. alkynylation was performed utilizing phenylglyoxylic acid as the photoinitiator, leading to the corresponding products in good to high yields, under household fluorescent light bulb irradiation When O-heterocycles were employed, the expected α-C-H alkynylation took place. In contrast, oxidative ring-opening to form a thioalkyne and an aldehyde was observed with S-heterocycles. Preliminary mechanistic experiments were presented to give first insights into this puzzling divergent reactivity. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5COA of Formula: C7H5IO2)

2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. COA of Formula: C7H5IO2 Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Cu(I)/sucrose-catalyzed hydroxylation of arenes in water: the dual role of sucrose》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Watanabe, Kohei; Takagi, Mio; Watanabe, Ayako; Murata, Shigeo; Takita, Ryo. Product Details of 625-99-0 The article mentions the following:

A protocol for the hydroxylation of aryl halides catalyzed by copper(I) and sucrose in neat water was developed. The dual role of sucrose, the reaction pathway, and the high selectivity for hydroxylation were investigated using a combination of exptl. and theor. techniques. The experimental part of the paper was very detailed, including the reaction process of 1-Chloro-3-iodobenzene(cas: 625-99-0Product Details of 625-99-0)

1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Product Details of 625-99-0

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Palladium-Catalyzed Synthesis of α-Carbonyl-α’-(Hetero)aryl Sulfoxonium Ylides: Scope and Insight into the Mechanism》 was published in Journal of Organic Chemistry in 2020. These research results belong to Janot, Christopher; Chagnoleau, Jean-Baptiste; Halcovitch, Nathan R.; Muir, James; Aissa, Christophe. Recommanded Product: Trimethylsulfoxonium iodide The article mentions the following:

Despite recent advances, a general method for the synthesis of α-carbonyl-α’-(hetero)aryl sulfoxonium ylides is needed to benefit more greatly from the potential safety advantages offered by these compounds over the parent diazo compounds Herein, the palladium-catalyzed cross-coupling of aryl bromides and triflates with α-carbonyl sulfoxonium ylides is reported. The use of this method for the modification of an active pharmaceutical ingredient and to the synthesis of a key precursor of antagonists of the neurokinin-1 receptor is also reported. In addition, the mechanism of the reaction was inferred from several observations. Thus, the oxidative addition complex [(XPhos)PhPdBr] and its dimer were observed by 31P{1H} NMR and these complexes were shown to be catalytically and kinetically competent. Moreover, a complex resulting from the transmetallation of [(XPhos)ArPdBr] (Ar = p-CF3-C6H4) with a model sulfoxonium ylide was observed by mass spectrometry. Finally, the partial rate law suggests that the transmetallation of and the subsequent deprotonation are rate-determining in the catalytic cycle. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.

Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Recommanded Product: Trimethylsulfoxonium iodide

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

《Sequential One-Pot Coupling Reactions of Diiodobenzenes, Propiolic Acid, and Aryl Halides for the Synthesis of Diarylalkynyl Arenes》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Ryu, Beomseok; Oh, Jonghoon; Lee, Sunwoo. Reference of 1-Bromo-4-iodobenzene The article mentions the following:

Diiodobenzenes were employed in palladium-catalyzed one-pot sequential reactions with propiolic acid and aryl halides to provided the corresponding diarylalkynyl benzenes. The combination of Pd(PPh3)4 (10 mol %) and DBU (5.0 equiv) gave optimal results in the sequence. Reactions with 1,2-diiodobenzene gave higher yields than those utilizing 1,3- and 1,4-diiodobenzenes. Furthermore, benzenes bearing electron-donating substituents gave higher yields than those with electron-withdrawing substituents. In the experimental materials used by the author, we found 1-Bromo-4-iodobenzene(cas: 589-87-7Reference of 1-Bromo-4-iodobenzene)

1-Bromo-4-iodobenzene(cas: 589-87-7) has been employed as reagent for in situ desilylation and coupling of silylated alkynes, as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids), as substrate in copper-free Sonogashira coupling in aqueous acetone in synthesis of β,β,dibromostyrenesReference of 1-Bromo-4-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com