Month: November 2022

Liu, Wei-wei published the artcileSynthesis, characterization, and biological evaluation of some novel glycosyl 1,3,4-thiadiazole derivatives as acetylcholinesterase inhibitors, Formula: C7H7IN2O, the publication is Heterocycles (2015), 91(2), 275-286, database is CAplus.

The corresponding 4-substituted glycosyl thiosemicarbazide derivatives were obtained by the reaction of glycosyl isothiocyanate with various hydrazides. Further cyclization with the system of p-TsCl/TEA led to the formation of N-glycosyl-5-substituted 1,3,4-thiadiazole-2-amine. Subsequent removal of the acetyl groups were conducted using the system of NaOMe/MeOH. The chem. structures of all new products were confirmed by IR, 1H NMR and ESI-HRMS. The acetylcholinesterase (AChE) inhibitory activities of those compounds were tested by Ellman’s method. Among them, the compound I possessed the best acetylcholinesterase-inhibition activity with IC₅0 of 18.38 ± 0.89 μM.

Heterocycles published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Weiwei published the artcileSynthesis of novel glycosyl 1,3,4-oxadiazole derivatives, Quality Control of 39115-95-2, the publication is Heterocyclic Communications (2014), 20(6), 333-338, database is CAplus.

A convenient and practical protocol was developed to synthesize glycosyl 1,3,4-oxadiazoles from D-glucosamine with good to excellent yields. The key step involved p-TsCl/pyridine-mediated cyclization under mild conditions. Subsequent removal of the acetyl groups in the last step, conducted using the system of NaOMe/MeOH, gave the desired N-acetyl-D-glucosamine 1,3,4-oxadiazole derivatives

Heterocyclic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Quality Control of 39115-95-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhou, Zheng-Xin published the artcileCooperative Ligand-Promoted P(III)-Directed Ruthenium-Catalyzed Remote Meta-C-H Alkylation of Tertiary Phosphines, Formula: C5H9IO2, the publication is Organic Letters (2021), 23(6), 2057-2062, database is CAplus and MEDLINE.

Herein, the authors disclose a Ru-catalyzed meta-selective C-H activation of phosphines by using intrinsic P(III) as a directing group. 2,2,6,6-Tetramethylheptane-3,5-dione acts as the ligand and exhibits an excellent performance in boosting the meta-alkylation. The protocol allows an efficient and straightforward synthesis of meta-alkylated tertiary phosphines. Several meta-alkylated phosphines were evaluated for Pd-catalyzed Suzuki coupling and are superior to com. available ortho-substituted phosphines. The practicability of this methodol. is further demonstrated by the synthesis of difunctionalized phosphines.

Organic Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C6H10F3NO, Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liang, Xinjie published the artcileCopper and L-(-)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air, Name: 2-Chloro-4-iodobenzoic acid, the publication is Tetrahedron Letters (2020), 61(33), 152222, database is CAplus.

L-(-)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95% ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.

Tetrahedron Letters published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Name: 2-Chloro-4-iodobenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liu, Yuliang published the artcilePhotoinduced Cross-Coupling of Aryl Iodides with Alkenes, Formula: C7H4ClIO2, the publication is Organic Letters (2021), 23(2), 427-432, database is CAplus and MEDLINE.

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes was developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes was proposed. The method enabled iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

Organic Letters published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Formula: C7H4ClIO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Cao, Lidong published the artcilep-MeOC₆H₄N₂⁺BF₄^–/TiCl₃: a novel initiator for halogen atom-transfer radical reactions in aqueous media, Category: iodides-buliding-blocks, the publication is Tetrahedron Letters (2008), 49(52), 7380-7382, database is CAplus.

With the combination of p-methoxybenzenediazonium tetrafluoroborate with TiCl₃ as the initiator, a wide range of halogen atom-transfer radical addition or cyclization reactions could be efficiently implemented in aqueous solution at room temperature

Tetrahedron Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Steverlynck, Joost published the artcileInfluence of branching on the chiral self-assembly of poly(phenylene ethynylene), Computed Properties of 165534-79-2, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2015), 53(1), 79-84, database is CAplus.

In this contribution, we report the synthesis of chiral all-conjugated branched poly(phenylene ethynylenes) with a controlled amount of branching. Subsequently, the self-assembly of these PPEs is studied by means of UV-vis, fluorescence spectroscopy, and DSC and the influence of branching is investigated. Finally, CD-spectroscopy is used to study the influence of branching and self-assembly on the chiral expression of these polymers. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 79-84.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C20H17FO4S, Computed Properties of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hackman, R. H. published the artcileImproved methods for the preparation of the x-ray contrast media iodoxyl and diodone, HPLC of Formula: 101-29-1, the publication is Journal of the Society of Chemical Industry, London (1946), 204-5, database is CAplus.

Important modifications have been introduced in the methods of preparation of iodoxyl (di-NaN-methyl-3,5-diiodochelidamate) and diodone (3,5-diiodo-4-pyridone-1-acetic acid) by which considerably higher yields are obtainable. Improved methods of iodination and methylation are described.

Journal of the Society of Chemical Industry, London published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C7H5I2NO3, HPLC of Formula: 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Budyka, Mikhail F. published the artcileProton-driven “one-way” photoisomerization due to energy transfer switching in styrylquinoline-merocyanine dyad, Related Products of iodides-buliding-blocks, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2014), 59-64, database is CAplus.

Photophys. and photochem. properties of the novel bichromophoric covalently linked dyad SQ3MC, where 2-styrylquinoline (SQ) and merocyanine (MC) chromophoric groups are connected by dioxytrimethylene bridge O-(CH₂)₃O, in comparison with model compounds 2-(4-methoxystyryl)quinoline MeSQ and 1-ethyl-2-(4-methoxystyryl)quinolinium perchlorate, which is O-methylated merocyanine MeMC, are investigated. In dyad SQ3MC, trans → cis photoisomerization of SQ moiety is quenched because of competing Forster resonance energy transfer (FRET) to MC fragment. However, reaction is switched on in protonated quasisym. dyad where pos. charged SQ fragment obtains the same chromophoric π-system as in MC chromophore. After deprotonation, photoisomerization of SQ fragment in trans → cis direction is again switched off but goes in cis → trans direction. Effect of “one-way” photoisomerization in the dyad SQ3MC is kinetic in nature and based on the difference in rates of competing processes in the excited state, in contrast to well-known one-way reactivity of diarylethylenes with large aryl substituents, where effect is thermodn. in nature and based on the difference in energies of the excited-state isomers and conformers.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Park, Hwangseo published the artcileStructure-based de novo design and identification of D816V mutant-selective c-KIT inhibitors, SDS of cas: 757978-19-1, the publication is Organic & Biomolecular Chemistry (2014), 12(26), 4644-4655, database is CAplus and MEDLINE.

To identify potent and selective inhibitors of D816V, the most common gain-of-function c-KIT mutant, the authors carried out structure-based de novo design using 7-azaindole as the core and the scoring function improved by implementing an accurate solvation free energy term. This approach led to the identification of new c-KIT inhibitors specific for the D816V mutant. The 3-(3,4-dimethoxyphenyl)-7-azaindole scaffold was optimized and represents a lead structure for the design of the potent and specific inhibitors of the D816V mutant. The results of mol. dynamics simulations indicate that hydrogen bonding interactions between the 7-azadindole moiety and the backbone groups of Cys673 are the most significant determinant for the potency and selectivity of c-KIT inhibitors.

Organic & Biomolecular Chemistry published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, SDS of cas: 757978-19-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com