Month: November 2022

Pacardo, Dennis B. published the artcileExploring the mechanism of Stille C-C coupling via peptide-capped Pd nanoparticles results in low temperature reagent selectivity, Product Details of C7H4ClIO2, the publication is Catalysis Science & Technology (2013), 3(3), 745-753, database is CAplus.

Stille coupling of PhSnCl₃ with aryl halides was catalyzed by palladium 2 nm nanoparticles, capped with Pd4 peptide, TSNAVHPTLRHL, the effects of halogen, substitution and temperature being qual. evaluated. The atom-leaching mechanism of Pd nanoparticle-driven Stille coupling is suggested, comprising initial oxidative addition at the particle surface, Pd atom abstraction and further reactions in solution The fate of the highly active Pd⁰ atoms released in solution was further elucidated. As a result, two reaction sites are present, the particle surface and pre-leached Pd atoms, thus different degrees of reactivity are possible. This effect was probed via aryl halide combinations that varied the halogen identity allowing for oxidative addition of two substrates simultaneously. The results demonstrate that the system was highly reactive for iodo-based compounds in the mixture at room temperature; however, reactivity at bromo-based substrates was only observed at slightly elevated temperatures of 40.0°. As such, substrate selectivity was evident from the catalytic materials that can be controlled based upon the aryl halide composition and reaction temperature Furthermore, both intermol. and intramol. selectivity is possible, thus raising the degree of reaction complexity that can be achieved.

Catalysis Science & Technology published new progress about 145343-76-6. 145343-76-6 belongs to iodides-buliding-blocks, auxiliary class Chloride,Iodide,Carboxylic acid,Benzene, name is 2-Chloro-4-iodobenzoic acid, and the molecular formula is C7H4ClIO2, Product Details of C7H4ClIO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Puleo, Thomas R. published the artcileNucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer, Formula: C6H6INO, the publication is Journal of the American Chemical Society (2021), 143(32), 12480-12486, database is CAplus and MEDLINE.

A general protocol for the direct C-H etherification of N-heteroarenes is reported. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alc. substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcs. with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.

Journal of the American Chemical Society published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, Formula: C6H6INO.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yasuda, Makoto published the artcileRadical coupling of iodocarbonyl compounds with butenylindium generated by transmetalation between cyclopropylmethylstannane and indium halides, Related Products of iodides-buliding-blocks, the publication is Organometallics (2009), 28(1), 132-139, database is CAplus.

The reaction of cyclopropylmethylstannane C₃H₅CH₂SnBu₃ (1) with α-iodocarbonyl compounds R¹R²C(I)COX (2) in the presence of either InBr₃ or InCl₃ gave the C-C coupling products, 2-cyclopropylethyl carbonyls C₃H₅CH₂CR¹R²COX (3; R¹, R² = H, Me; X = PhO, PhCH₂O, CH₂:CHCH₂O, ^tBuO, Et₂N, Ph; R¹R²C(I)COX = 3-iodo-γ-butyrolactone). Various types of iodocarbonyl compounds such as esters, amides, and ketones were applied to this system to afford the corresponding compounds 3. The reaction mechanism comprises transmetalation between cyclopropylmethylstannane and indium halides, providing 3-butenylindium dihalide and di-3-butenylindium halide, as confirmed by NMR spectroscopy. The reactivity of di-3-butenylindium halide was greater than that of monobutenyl species. The active species, di-3-butenylindium halide, was stabilized by complexation using DPPE, and its structure was analyzed using x-ray crystallog. The solid state of the complex shows a linear structure with a core (-Cl-In-Cl-In-P-C-C-P-In-)_n with five-coordinated indium centers. The reaction between 1 and 2, mediated by indium halides, proceeded in a radical manner, regenerating after recyclization of 6-oxo-1-indiohex-3-yl radical the initial cyclopropylmethyl moiety. The in situ-generated alkylindium species and a small amount of oxygen, which can be supplied by atm. air, initiated the radical reaction.

Organometallics published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C25H23NO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Watari, Fumio published the artcileInfrared absorption spectra of molecular complexes of pyridine. III. Molecular complexes with iodine and iodine halides, Synthetic Route of 6443-90-9, the publication is Sci. Rept. Res. Inst., Tohoku Univ. (1962), Ser. A 14(No. 1), 64-9, database is CAplus.

cf. CA 56, 9594a. When I, ICl, or IBr were dissolved in pyridine (I), new bands were observed at 627-624, 1012-1007, 1213, 1246 and 1454 cm.^-1, which were assigned as the shifted bands of ν_6a, ν₁, ν₃, 2ν_6a, and ν_19b, resp., of I. They are well defined: others appear only as a shoulder of the pure I band; some may mutually enhance their intensity, others remain almost unaffected. The rest of the absorptions of the I solution were nearly the same in band location and intensity as those of pure I. Spectra of the solid complexes are analogous to the solution spectra, though in the latter there are the shifting and intensity-changing effects in the case of liquid I. The difference of shift of 624-627 and 1007-1012 cm.^-1 is parallel to the electronegativities of the added interhalogen compounds; ICl shifts a band most markedly from the pure I spectrum.

Sci. Rept. Res. Inst., Tohoku Univ. published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C14H28O5S, Synthetic Route of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tanner, George A. published the artcileReabsorption and secretion of p-aminohippurate and Diodrast in Necturus kidney, HPLC of Formula: 101-29-1, the publication is American Journal of Physiology (1966), 210(2), 221-31, database is CAplus and MEDLINE.

Intact animals spontaneously show net reabsorption, no net transport, or net secretion of p-aminohippurate(PAH) and Diodrast. Net reabsorption was converted to net secretion by intraarterial doses of fatty acids such as octanoate. In kidneys perfused with modified Ringer solution, strong net PAH reabsorption was observed; with 1mM octanoate, net secretion was usually produced. The action of octanoate is specific and reversible. With PAH-carboxyl-¹⁴C perfused from either the aortic or renal portal side and unlabeled PAH from the opposite side, urine PAH sp. activity differed from that of filtered PAH. Unidirectional PAH movements, calculated using a 2-compartment analysis, suggest that Diodrast inhibits reabsorptive and secretory movements, whereas octanoate inhibits primarily the reabsorptive movement. Tubular transport of PAH and Diodrast in Necturus kidney may involve active processes which move these compounds into proximal tubule cells from luminal and peritubular sides.

American Journal of Physiology published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ichijo, Keisuke published the artcileCrystal Structures and Optical Properties of Cyanine Dyes Depending on Various Counter Anions, Product Details of C12H14IN, the publication is ACS Omega (2021), 6(42), 28421-28431, database is CAplus and MEDLINE.

In this study, cyanine cations with various counter anions were prepared as examples of ionic materials constructed using charged π-conjugated systems. A series of ion pairs was obtained by anion exchange reactions using iodide salts of carbocyanine dyes. The optical properties were measured by UV/vis absorption and fluorescence spectroscopy; measurements performed in CHCl₃ (less-polar solvent) were altered by the influence of the counter anions. The packing structures of nine crystals were determined by single-crystal X-ray anal. Moreover, the locations of the anions relative to the cations were stabilized by hydrogen bonding and categorized into two types. In addition, delocalization of the neg. charge of the anions on cyanine cations was explained by d. functional theory calculations Furthermore, it was concluded that the stack formation of cyanine cations depends on the size and structure of the anions.

ACS Omega published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Willenbrink, J. published the artcileMechanism of excretion of urinary contrast media, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, the publication is Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie (1959), 16-18, database is CAplus.

3,5-Di-iodo-4-pyridone-N-acetic acid (I) and 3,5-diacetamido-2,4,6-triiodobenzoic acid (II) labeled with radioiodine were injected into Hippocampus cudae, which had no glomeruli. The excretion of I was 5 times that of II. Excretion through bile and intestine was insignificant. The excretion of I in rabbits decreased with a plasma concentration up to 10 mg. % and remained constant between 20 and 1280 mg. %. Blocking the tubules with 200 mg. % p-aminohippuric acid (PAH) caused a depression of excretion to 1-10 mg. %. The rate of excretion of II remained unchanged within the range of 1 to 1280 mg. % in the plasma and was not influenced by PAH.

Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C5H12O2, Recommanded Product: 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hong, Seunghee published the artcileDesign, Synthesis, and Evaluation of 3,5-Disubstituted 7-Azaindoles as Trk Inhibitors with Anticancer and Antiangiogenic Activities, Synthetic Route of 757978-19-1, the publication is Journal of Medicinal Chemistry (2012), 55(11), 5337-5349, database is CAplus and MEDLINE.

Tropomyosin-related kinase A (TrkA) is considered a promising target in the development of a therapeutic treatment of cancer and pain. Thus, a series of novel 7-azaindole-based Trk kinase inhibitors, e. g. I, were designed and synthesized through the structure-based design strategy. By varying the functional groups at the 3 and 5 positions of a 7-azaindole scaffold, the structure-activity relationships (SAR) profiles were explored and a series of potent Trk inhibitors were identified. Representative derivatives, including I, showed desirable activity in cellular proliferation and apoptosis assays. Moreover, these inhibitors exhibited noteworthy antiangiogenic activity.

Journal of Medicinal Chemistry published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Synthetic Route of 757978-19-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Reddy, M. L. Chenna published the artcileSynthesis of New Sulfoximine-Tethered Alkynones and Further Extension towards Metal-Free Synthesis of Pyrimidines, Amino Pyrimidines, Pyrazoles and Isoxazoles, Category: iodides-buliding-blocks, the publication is ChemistrySelect (2019), 4(33), 9573-9577, database is CAplus.

A metal-free and divergent synthetic method has been successfully developed for the synthesis of sulfoximine-tethered pyrimidines, aminopyrimidines, pyrazoles and isoxazoles. Two key sulfoximine tethered alkynone intermediates ((tert-butyldiphenylsilyl)imino)(2-oxo-4-phenylbut-3-yn-1-yl)(phenyl)-λ6-sulfanone and ((tert-butyldiphenylsilyl)imino)(2-oxopent-3-yn-1-yl)(phenyl)-λ6-sulfanone were reported for the first time and were used as the common building blocks to construct these heterocycles. Good functional group tolerability was observed and the products were isolated in excellent yields.

ChemistrySelect published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zengerling, Lydia published the artcileA Palladium-free Sonogashira coupling protocol employing an in situ prepared copper/chelating 1,2,3-triazolylidene system, Safety of 1-Iodohexane, the publication is Synlett (2021), 32(6), 616-620, database is CAplus.

A new, palladium-free Sonogashira coupling reaction protocol using a catalytic system that comprises a simple, cheap, widely available copper salt and a chelating 1,2,3-triazolylidene ligand precursor is reported. This protocol provides the desired coupling products in moderate to very good yields.

Synlett published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C26H25N5O3, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com