Month: November 2022

El Maghraby, M. A. published the artcileSymmetrical dicationic cyanine dyes incorporating pyrazolo-pyrano oxazone (pyrimidine) moiety, Formula: C12H14IN, the publication is Aswan Science & Technology Bulletin (1991), 3-14, database is CAplus.

3-Amino-6-methyl-5-aryl-2,5-dihydropyrano[2,3-c]pyrazole-4-carbonitriles were acid hydrolyzed to the corresponding -4-carboxylic acids (55-57% yield), which were condensed with Ac₂O to give 3,7-dimethyl-4-aryl-1-acetylpyrazolopyranooxazinones (58-61%); the corresponding pyrimidinones (42-45%) were obtained using ammonia. Oxidation of these products with SeO₂ converted the 2 Me groups (58-64%) to CHO groups. Condensation with α-picoline or quinaldine ethiodides gave 45-65% I (X = Cl, NO₂; Y = 1-ethylpyridinium-2-yl iodide, 1-ethylquinolinium-2-yl iodide; Z = O, NH). The visible absorption spectra of I were recorded.

Aswan Science & Technology Bulletin published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manoussakis, George published the artcileHalogen ring monosubstituted benzoic acid hydrazides as ligands. II. Ultraviolet spectra and pK determination, Safety of 4-Iodobenzohydrazide, the publication is Canadian Journal of Chemistry (1973), 51(5), 811-14, database is CAplus.

The uv spectra of 12 halogen-substituted benzoic acid hydrazides were reported. A very intense band in the region 225-260 mμ and second one of low intensity at 270-290 mμ were assigned to π â†?π* and n â†?π* transition, resp. The pK1 and pK2 of these hydrazides, corresponding to the Broensted acids XC6H4C(O)NHNH2 and XC6H4C(OH):NNH2 respectively were obtained spectrophotometrically (X = o-, m-, or p-F, Cl, Br, iodo). The influence of the nature and the position of the halogen atom on the pK values was discussed.

Canadian Journal of Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Manoussakis, G. E. published the artcileHalogen ring monosubstituted benzoic acid hydrazides as ligands. 1. Preparation and interpretation of infrared spectra, Safety of 4-Iodobenzohydrazide, the publication is Chimika Chronika (1972), 1(3-4), 182-7, database is CAplus.

The ortho-, meta-, and para-halo derivatives of benzoic acid hydrazides were obtained by allowing the Et ester of the halo-substituted acid to react with H2NNH2.H2O. The ir spectra of the hydrazides indicated that the donor properties of the halogen atoms were not significant, but enhanced possibilities for intra- and intermol. H bonding. The coordination of these hydrazides with metals is discussed.

Chimika Chronika published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Safety of 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Gunaratna, Medha J. published the artcileSynthesis of probe molecules, 6-(dimethylamino)-2-phenylisoindolin-1-ones, for mechanistic studies of firefly luciferase inhibition, Application of (2-Amino-5-iodophenyl)methanol, the publication is Heterocycles (2021), 103(1), 231-248, database is CAplus and MEDLINE.

In order to probe firefly luciferase inhibition’s mechanism, we synthesized two probe mols. I and II, mimicking F-53. Mol. I contains an azido-appended side chain in the aromatic ring of F-53, while 2 possesses an azido and a carboxylic acid group appended side chains. Both synthetic schemes are readily amenable to large-scale syntheses. Mol. I was made from 2-allylaniline, which was derived from a thermal-induced aromatic-Claisen rearrangement of N-allylaniline. The azido-appended side chain of II was installed from a Horner-Wadsworth-Emmons reaction and the carboxylic acid side chain from a Sonogashira reaction.

Heterocycles published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C7H8INO, Application of (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fleming, H. Creswell published the artcileNuclear quadrupole resonance investigation of iodine monochloride complexed with pyridines, Synthetic Route of 6443-90-9, the publication is Journal of the American Chemical Society (1971), 93(20), 5030-4, database is CAplus.

The 35Cl and 127I nuclear quadrupole resonance absorption frequencies of pyridine-ICl and 4-methylpyridine-ICI was measured as a function of temperature Their resp. values at 273.2°K are 21.136 ± 0.01, 21.175 ± 0.01, 464.28 ± 0.04, and 462.76 ± 0.04 MHz. Their temperature coefficients were +2.2, +2.5, – 28, and – 24 kHz/°K. Application of the Townes and Dailey theory with neglect of s hydridization at the halogen atoms results in the following charge ds. in each complex: pyridine (or 4-methylpyridine) +0.26; I +0.35; and Cl – 0.61 electron. A valence-bond interpretation indicates a 57% contribution of the “nobond” wave function to the ground state. A representation in which the charge-transfer and electrostatic wave functions are explicitly included contains a maximum of 26% charge-transfer character in the ground-state wave function. Classical electrostatic forces thus appear to play a dominant role in the stabilization of these complexes. The charge-transfer contributions are nonnegligible, but a representation of the complex structure based completely on the chargetransfer model is likely to give misleading results.

Journal of the American Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Synthetic Route of 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chan, Bryan K. published the artcileDiscovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor, Quality Control of 1260672-72-7, the publication is Journal of Medicinal Chemistry (2016), 59(19), 9080-9093, database is CAplus and MEDLINE.

Inhibitors targeting the activating mutants of the epidermal growth factor receptor (EGFR) have found success in the treatment of EGFR mutant pos. nonsmall-cell lung cancer. A secondary point mutation (T790M) in the inhibitor binding site has been linked to the acquired resistance against those first generation therapeutics. Herein, the authors describe the lead optimization of a series of reversible, pan-mutant (L858R, del_746-750, T790M/L858R, and T790M/del_746-750) EGFR inhibitors. By use of a noncovalent double mutant (T790M/L858R and T790M/del_746-750) selective EGFR inhibitor I as a starting point, activities against the single mutants (L858R and del_746-750) were introduced through a series of structure-guided modifications. The in vitro ADME-PK properties of the lead mols. were further optimized through a number of rational structural changes. The resulting inhibitor II exhibited excellent cellular activity against both the single and double mutants of EGFR, demonstrating target engagement in vivo and ADME-PK properties that are suitable for further evaluation. The reversible, noncovalent inhibitors described complement the covalent pan-mutant EGFR inhibitors that have shown encouraging results in recent clin. trials.

Journal of Medicinal Chemistry published new progress about 1260672-72-7. 1260672-72-7 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Iodide, name is 6-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and the molecular formula is C6H3ClIN3, Quality Control of 1260672-72-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Jianbo published the artcileSynthesis of 2-Quinolinones through Palladium(II) Acetate Catalyzed Cyclization of N-(2-Formylaryl)alkynamides, Name: (2-Amino-5-iodophenyl)methanol, the publication is Synlett (2015), 26(12), 1744-1748, database is CAplus.

A Pd(OAc)₂-catalyzed cyclization of N-(2-formylaryl)alkynamides initiated by the oxypalladation of alkynes was developed. The method provides a new approach for the efficient and atom-economical synthesis of 2-quinolinone derivatives

Synlett published new progress about 53279-83-7. 53279-83-7 belongs to iodides-buliding-blocks, auxiliary class Iodide,Amine,Benzene,Alcohol, name is (2-Amino-5-iodophenyl)methanol, and the molecular formula is C15H14O3, Name: (2-Amino-5-iodophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Chun-Hua published the artcileDirect Intramolecular Aminoboration of Allenes, Safety of (2-Iodo-4-nitrophenyl)methanol, the publication is Organic Letters (2020), 22(13), 5090-5093, database is CAplus and MEDLINE.

Direct intramol. aminoboration of sulfonamidoallenes was realized using BCl₃ as a boron source. The reactions benefited from the interaction between BCl₃ and sulfonamides and provided a variety of borylvinyl heterocycles, e.g. I, in good isolated yields. When chiral substrates were involved in the reactions, high stereoselectivity was observed, as can be ascertained by single-crystal X-ray diffraction experiments Derivatization of the thus-obtained borylvinyl compounds proceeded readily, and different functionalities could be obtained via oxidation, halogenation, and Suzuki coupling reactions.

Organic Letters published new progress about 500563-90-6. 500563-90-6 belongs to iodides-buliding-blocks, auxiliary class Nitro Compound,Iodide,Benzene,Alcohol, name is (2-Iodo-4-nitrophenyl)methanol, and the molecular formula is C7H5Br2F, Safety of (2-Iodo-4-nitrophenyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Maeda, Yoshiaki published the artcilePractical Asymmetric Synthesis of Chiral Sulfoximines via Sulfur-Selective Alkylation, Safety of 1-Iodohexane, the publication is Journal of Organic Chemistry, database is CAplus and MEDLINE.

Herein, an asym. synthesis of chiral sulfoximines RS(=NPiv)(O)C(CH₃)₃ (R = Me, i-Bu, 4-(1,3-dioxolan-2-yl)butyl, etc.) through a stereospecific S-alkylation of readily accessible 2,2-dimethyl-N-[(S)-2-methylpropane-2-sulfinyl]propanamide under practical conditions was demonstrated. A key to establishing the practical conditions was the identification of the intermediate structure in the previously reported S-alkylation by X-ray crystallog. anal.

Journal of Organic Chemistry published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mason, Stephen J. published the artcileSolid-phase methods for the synthesis of cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Journal of Organic Chemistry (2005), 70(8), 2939-2949, database is CAplus and MEDLINE.

We report here a series of studies that explore solid-phase methodologies for the synthesis of various cyanine dyes. The scope of the previously reported catch-and-release method using sulfonyl chloride resin has now been extended to include pentamethine and water-soluble cyanine dyes. We also report a new and chem. distinct synthetic strategy, employing the stepwise attack of heterocyclic carbon nucleophiles on immobilized polyene-chain precursors, allowing the clean synthesis of hydrophobic and hydrophilic trimethine and pentamethine dyes from more easily obtained starting materials. Overall, both approaches appear to be robust and versatile strategies to delivering a wide range of cyanine-based dyes in high purity.

Journal of Organic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com