Month: November 2022

Bowmaker, G. A. published the artcileNuclear quadrupole resonance of charge-transfer complexes. II. Amine-halogen complexes, COA of Formula: C5H5ClIN, the publication is Australian Journal of Chemistry (1969), 22(10), 2047-59, database is CAplus.

Nuclear quadrupole resonance frequencies have been measured for some of the halogen nuclei in a number of crystalline charge-transfer complexes of amines with bromide, I, IBr, and ICl. From these measurements it has been possible to calculate approx. charge distributions for the Br, IBr, and ICl complexes of 3,5-dibromopyridine. The results correlate well with a three-center delocalized L.C.A.O.-M.O. bonding theory. The correlation of this M.O. description with Mulliken’s charge-transfer bonding scheme for n-σ complexes is discussed. This approach indicates the importance of considering an “ionic” structure (which does not involve transfer of charge from the donor to the acceptor) in the electronic ground state of these complexes.

Australian Journal of Chemistry published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, COA of Formula: C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Qi, Ya-Lin published the artcileTwo birds with one stone: a NIR fluorescent probe for mitochondrial protein imaging and its application in photodynamic therapy, Product Details of C12H14IN, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(30), 6068-6075, database is CAplus and MEDLINE.

Mitochondrial proteins, most of which are encoded in the nucleus and the rest of which are regulated by the mitochondrial genome, play pivotal roles in essential cellular functions. However, fluorescent probes that can be used for monitoring mitochondrial proteins have not yet been widely developed, thereby severely limiting the exploration of the functions of proteins in mitochondria. Towards this end, here we propose a near-IR (NIR) fluorescence probe MPP to effectively illuminate the dynamic changes in mitochondrial proteins in live cells under oxidative stress, with excellent temporal and spatial resolution Of particular importance, MPP extends the study of the pharmacol. involved in apoptosis induced by anti-cancer drugs (hydroxycamptothecin (HCPT), epirubicin (Epi) and cyclophosphamide (CPA)) for the first time. Furthermore, employing a protein-activatable strategy, this probe could serve as an excellent phototherapeutic agent in photodynamic therapy (PDT). Finally, in vivo experiments suggest that this versatile probe can be used to image tumors in HeLa tumor-bearing mice for 24 h, which demonstrates that our probe could play a dual role as a robust phototherapeutic and imaging agent.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Product Details of C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Yubo published the artcileChiral Donor Photoinduced-Electron-Transfer (d-PET) Boronic Acid Chemosensors for the Selective Recognition of Tartaric Acids, Disaccharides, and Ginsenosides, HPLC of Formula: 165534-79-2, the publication is Chemistry – A European Journal (2011), 17(27), 7632-7644, S7632/1-S7632/67, database is CAplus and MEDLINE.

A modular approach was proposed for the preparation of chiral fluorescent mol. sensors, in which the fluorophore, scaffold, and chirogenic center can be connected by ethynyl groups, and these modules can easily be changed to other structures to optimize the mol. sensing performance of the sensors. This modular strategy to assembly chiral sensors alleviated the previous restrictions of chiral boronic acid sensors, for which the chirogenic center, fluorophore, and scaffold were integrated, thus it was difficult to optimize the mol. structures by chem. modifications. The authors demonstrated the potential of their new strategy by the preparation of a sensor with a larger scaffold. The photoinduced electron-transfer (PET) effect is efficient even with a large distance between the N atom and the fluorophore core. Furthermore, the rarely reported donor-PET (d-PET) effect, which was previously limited to carbazole, was extended to phenothiazine fluorophore. The contrast ratio, i.e., PET efficiency of the new d-PET sensor, is increased to 8.0, compared to 2.0 with the previous carbazole d-PET sensors. Furthermore, the ethynylated phenothiazine shows longer excitation wavelength (centered at 380 nm) and emission wavelength (492 nm), a large Stokes shift (142 nm), and high fluorescence quantum yield in aqueous solution (Φ=0.48 in MeOH/water, 3:1 volume/volume). Enantioselective recognition of tartaric acid was achieved with the new d-PET boronic acid sensors. The enantioselectivity is up to 10 (ratio of the binding constants toward D– and L-tartaric acid, k_D/k_L). A consecutive fluorescence enhancement/decrease was observed, thus the authors propose a transition of the binding stoichiometry from 1:1 to 1:2 as the analyte concentration increases, which is supported by mass spectra anal. The boronic acid sensors were used for selective and sensitive recognition of disaccharides and glycosylated steroids (ginsenosides).

Chemistry – A European Journal published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C4H6N4O, HPLC of Formula: 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ermolenko, Mikhail S. published the artcilePyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles, HPLC of Formula: 866638-72-4, the publication is Tetrahedron (2013), 69(1), 257-263, database is CAplus.

The transformations of substituted 3/5-trifluoromethylpyrazoles to the corresponding NH-pyrazole-3/5-carboxylic acids are reported. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare

Tetrahedron published new progress about 866638-72-4. 866638-72-4 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Pyrazole,Fluoride,Iodide, name is 4-Iodo-3-(trifluoromethyl)-1H-pyrazole, and the molecular formula is C4H2F3IN2, HPLC of Formula: 866638-72-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tahtaoui, Chouaib published the artcileOn the Use of Nonfluorescent Dye Labeled Ligands in FRET-Based Receptor Binding Studies, Synthetic Route of 606-55-3, the publication is Journal of Medicinal Chemistry (2005), 48(24), 7847-7859, database is CAplus and MEDLINE.

The efficiency of fluorescence resonance energy transfer (FRET) is dependent upon donor-acceptor proximity and spectral overlap, whether the acceptor partner is fluorescent or not. The authors report here on the design, synthesis, and characterization of two novel pirenzepine derivatives that were coupled to patent blue VF and pinacyanol dyes. These nonfluorescent compounds, when added to cells stably expressing enhanced green fluorescent protein (EGFP)-fused muscarinic M1 receptors, promote EGFP fluorescence extinction in a time-, concentration-, and atropine-dependent manner. They display nanomolar affinity for the muscarinic receptor, determined using either FRET or classical radioligand binding conditions. The authors provide evidence that these compounds behave as potent acceptors of energy from excited EGFP with quenching efficiencies comparable to those of analogous fluorescent bodipy or rhodamine red pirenzepine derivatives The advantages they offer over fluorescent ligands are illustrated and discussed in terms of reliability, sensitivity, and wider applicability of FRET-based receptor binding assays.

Journal of Medicinal Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Synthetic Route of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Saiter, Jeremy published the artcileDirect Trifluoromethoxylation without OCF₃-Carrier through In Situ Generation of Fluorophosgene, Formula: C5H9IO2, the publication is European Journal of Organic Chemistry (2021), 2021(22), 3139-3147, database is CAplus.

The method represented the preparation of a range of trifluoromethoxylated structures R-OCF₃ [R = undecanyl, (CH₂)₂Ph, 4-BrC₆H₄CH₂, etc.] with no use of an intermediate trifluoromethoxylating reagent, but in situ construction and use of the F₃CO anion as a salt, avoiding the presence of a useless side-product resulting from activation of an OCF₃ carrier.

European Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fialkov, Ya. A. published the artcileComplex formation by trihydroxyglutaric acid with some metals. I. Complex formation of trihydroxyglutaric acid with trivalent iron, SDS of cas: 6443-90-9, the publication is Zhurnal Neorganicheskoi Khimii (1956), 2504-16, database is CAplus.

Optically inactive trihydroxyglutaric acid (I) reacts with aqueous Fe(NO₃)₃ to form a Fe-bearing anion. From experiments carried out at low pH values (<2) and from equilibrium studies of Fe sal⁺ (where sal is the bivalent salicylate radical) with I at pH = 3, and of Fe sal₂^– with the disodium salt of I (at pH = 6), optical d. and elec.-cond data were obtained which supported the hypothesis of a complex in which the Fe:I ratio was 1:1. At low pH values the principal species is H[FeC₅H₄O₇]. At pH = 6, the anion [FeC₅H₄O₇]^– is characteristic, whereas at pH = 10, the anion becomes [FeC₅H₃O₇]^—. The equilibrium constant for the reaction [FeC₅H₄O₇]^– + 2H⁺ â†?C₅H₆O₇^— + Fe⁺⁺⁺ is 0.12. At about pH = 6, the trihydroxyglutarate complex of Fe⁺⁺⁺ is probably more stable than is the corresponding tartrate complex.

Zhurnal Neorganicheskoi Khimii published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, SDS of cas: 6443-90-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Piccialli, Vincenzo published the artcileBromination and iodination of donor-acceptor cyclopropanes. Evidence for an ET mechanism, Formula: C5H5ClIN, the publication is Tetrahedron Letters (2002), 43(45), 8067-8070, database is CAplus.

Et 2,2-dimethoxycyclopropanecarboxylates 1a-d react easily with Br₂ and I₂ in CCl₄ or CH₂Cl₂ leading, in high yields, to 1-ethyl- or 4-methyl-2-halobutanedioates 2 and 3, resp. Bromination in the presence of pyridine, NBS, tri-Me phosphate, and iodination with ICl and ICl/pyridine was also performed. A common SET mechanism may be proposed for both halogenations; depending on the reaction conditions, bromination can also occur via acid-catalyzed or S_E2 routes. The reaction of the 2-ethoxy analogs cis-12 and trans-12 with the same halogens proceeds in a similar manner, giving 3-formyl-2-halo esters along with the corresponding diethylacetals as main products. Iodination of 12 with the catalytic system NaI/m-CPBA/18-crown-6 also was studied.

Tetrahedron Letters published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Formula: C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Neumann, Fernanda published the artcileDYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives, Recommanded Product: 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, the publication is Scientific Reports (2018), 8(1), 1-12, database is CAplus and MEDLINE.

Inhibition of DYRK1A kinase, produced by chromosome 21 and consequently overproduced in trisomy 21 subjects, has been suggested as a therapeutic approach to treating the cognitive deficiencies observed in Down syndrome (DS). We now report the synthesis and potent DYRK1A inhibitory activities of fluoro derivatives of 3,5-di(polyhydroxyaryl)-7-azaindoles (F-DANDYs). One of these compounds (3-(4-fluorophenyl)-5-(3,4-dihydroxyphenyl)-1H-pyrrolo[2,3-b]pyridine, 5a) was selected for in vivo studies of cognitive rescuing effects in a standard mouse model of DS (Ts65Dn line). Using the Morris water maze task, Ts65Dn mice treated i.p. with 20 mg/kg of 5a performed significantly better than Ts65Dn mice treated with placebo, confirming the promnesiant effect of 5a in the trisomic mice. Overall, these results demonstrate for the first time that selective and competitive inhibition of DYRK1A kinase by the F-DANDY derivative 5a may provide a viable treatment strategy for combating the memory and learning deficiencies encountered in DS.

Scientific Reports published new progress about 757978-19-1. 757978-19-1 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide,Sulfamide,Benzene, name is 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, and the molecular formula is C13H8BrIN2O2S, Recommanded Product: 5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, Hassan Abazied published the artcileSynthesis, spectral behavior and biological activity of some novel 1,3,4-oxadiazine cyanine dyes, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is European Journal of Chemistry (2015), 6(2), 151-156, database is CAplus.

New methine cyanine dyes covering monomethine cyanine dyes and dimethine cyanine dyes derived from benzo[(2,3-b)benzoxazine; (2,3-e)1,3,4-oxadiazine]-5,12-dione were prepared The electronic visible absorption spectra of all the synthesized cyanine dyes were investigated in 95% ethanol solution Biol. activity for a number of selected compounds was tested and evaluated against various bacterial strains (Bacillus subtilis, Escherichia coli, Pseudomona aeruginosa and Staphylococcus aureus). Structural determination was carried out via elemental anal., visible, mass, IR and 1_H NMR spectroscopic data.

European Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H20Cl2N4, Recommanded Product: 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com