Month: November 2022

Plewe, Michael B. published the artcileDiscovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors, Computed Properties of 1146615-52-2, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 127983, database is CAplus and MEDLINE.

We identified and explored the structure-activity relationship (SAR) of a novel heterocyclic chem. series of arenavirus cell entry inhibitors. Optimized lead compounds, including diphenyl-substituted imidazo[1,2-a]pyridines, benzimidazoles, and benzotriazoles exhibited low to sub-nanomolar potency against both pseudotyped and infectious Old and New World arenaviruses, attractive metabolic stability in human and most nonhuman liver microsomes as well as a lack of hERG K + channel or CYP enzyme inhibition. Moreover, the straightforward synthesis of several lead compounds (e.g., the simple high yield 3-step synthesis of imidazo[1,2-a]pyridine I) could provide a cost-effective broad-spectrum arenavirus therapeutic that may help to minimize the cost-prohibitive burdens associated with treatments for emerging viruses in economically challenged geog. settings.

Bioorganic & Medicinal Chemistry Letters published new progress about 1146615-52-2. 1146615-52-2 belongs to iodides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Bromide,Iodide, name is 3-Bromo-6-iodo-imidazo[1,2-a]pyridine, and the molecular formula is C7H4BrIN2, Computed Properties of 1146615-52-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

AL-Shuaeeb, Riyadh Ahmed Atto published the artcileDiversity-oriented synthesis of fused thioglycosyl benzo[e][1,4]oxathiepin-5-ones and benzo[f][1,4]thiazepin-5(2H)-ones by a sequence of palladium-catalyzed glycosyl thiol arylation and deprotection-lactonization reactions, Related Products of iodides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2015), 13(44), 10904-10916, database is CAplus and MEDLINE.

An efficient synthesis of thioglycosylated benzo[e][1,4]oxathiepin-5-one, e.g. I, and benzothiazepinone derivatives by a sequence of palladium-catalyzed glycosyl thiol arylation followed by deprotection-lactonization reactions has been reported. This diversity-oriented strategy enabled access to unknown complex cyclic scaffolds with polyhydroxylated appendages of biol. interest.

Organic & Biomolecular Chemistry published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C10H9IO4, Related Products of iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Inokuma, Tsubasa published the artcileOrganocatalyzed Isomerization of α-Substituted Alkynoates into Trisubstituted Allenoates by Dynamic Kinetic Resolution, COA of Formula: C5H9IO2, the publication is ChemCatChem (2012), 4(7), 983-985, database is CAplus.

A highly enantioselective synthesis of trisubstituted allenoates through the isomerization of alkynoates catalyzed by benzothiadiazine organocatalyst is demonstrated. From the examination of the reaction time course, that organocatalyst predominantly recognized one of the enantiomers of alkynoates and mediated the isomerization of alkynoates through dynamic kinetic resolution is disclosed.

ChemCatChem published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, COA of Formula: C5H9IO2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Szczesniak, Piotr published the artcilePhoto-Fries-type rearrangement of cyclic enamides. An efficient route to structurally diverse five-membered enaminones, Synthetic Route of 638-45-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(12), 1898-1901, database is CAplus and MEDLINE.

A simple, efficient and user-friendly protocol for the preparation of structurally diverse enaminones e.g., I from enamides e.g., II has been developed. The strategy is based on a photo-induced intramol. Fries-type rearrangement. The photochem. transformation proceeds under mild reaction conditions, applies to a broad substrate range, is highly economic, and limits the amount of waste produced. The proposed methodol. was used as a key step in the synthesis of dihydrojasmone an important fragrance compound

Chemical Communications (Cambridge, United Kingdom) published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C8H17Br, Synthetic Route of 638-45-9.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Li, Dejiang published the artcileSynthesis and fungicidal activities of 2,5-bis(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl] pyridines, Recommanded Product: 4-Iodobenzohydrazide, the publication is Heterocyclic Communications (2006), 12(5), 383-388, database is CAplus.

In search of better bio-active compounds, a series of novel 2,5-bis[(3-aryl)-1,2,4-triazolo[3,4-b]-[1,3,4]thiadiazole-6-yl]pyridines were synthesized in high yields by cyclization of 3-aryl-4-amino-5-mercapto-1,2,4-triazoles with 2,5-pyridine dicarboxylic acid. The compounds, bis(aryl)-triazolothiadiazolyl-pyridines, exhibited good fungicidal activities against Cerospora beticola sacc.

Heterocyclic Communications published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yang, Ze-Peng published the artcileThe Asymmetric Synthesis of Amines via Nickel-Catalyzed Enantioconvergent Substitution Reactions, Product Details of C6H13I, the publication is Journal of the American Chemical Society (2021), 143(7), 2930-2937, database is CAplus and MEDLINE.

Herein, two mild methods was reported for the catalytic enantioconvergent synthesis of protected dialkyl carbinamines such as RCHXR¹ [R = i-Bu, n-hexyl, (CH₂)₅F, etc.; R¹ = Et, i-Bu, (CH₂)₂Ph, etc.; X = NHBoc, Phth, NHFmoc, etc.], both of which use a chiral nickel catalyst to couple an alkylzinc reagent with α-phthalimido alkyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid. The methods were versatile, providing dialkyl carbinamine derivatives that bear an array of functional groups. Further, for couplings of NHP esters a one-pot variant wherein the NHP ester was generated in situ, allowing the generation of enantioenriched protected dialkyl carbinamines in one step from com. available amino acid derivatives was also described. The utility of this method by applying it to the efficient catalytic enantioselective synthesis of a range of interesting target mols. was demonstrated.

Journal of the American Chemical Society published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C12H6NNaO4, Product Details of C6H13I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Blakemore, Caroline A. published the artcileScalable, telescoped hydrogenolysis-enzymic decarboxylation process for the asym. synthesis of (R)-α-heteroaryl propionic acids, SDS of cas: 884495-13-0, the publication is Organic Process Research & Development (2021), 25(3), 421-426, database is CAplus.

Enantiopure α-aryl propionic acids are useful building blocks for pharmaceutical research and can be accessed enzymically using arylmalonate decarboxylases (AMDases) from the corresponding malonic acids. However, the intrinsic instability of malonic acids is a major drawback to this approach in which spontaneous decarboxylation can occur, subsequently eroding enantioselectivity and giving rise to racemic products. This was particularly evident for a panel of N-heterocyclic propionic acids that we wished to access using the approach. Herein, we describe a process to overcome the spontaneous decarboxylation problem in which hydrogenolysis of the corresponding dibenzyl malonates was performed in a biphasic toluene-basic aqueous buffer mixture and telescoped into the subsequent AMDase step. This procedure enabled compounds to be accessed in high enantioselectivities and was successfully demonstrated on 120 g with high yield (76%) and ee (98%).

Organic Process Research & Development published new progress about 884495-13-0. 884495-13-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Fluoride,Iodide,Ether, name is 5-Fluoro-4-iodo-2-methoxypyridine, and the molecular formula is C6H5FINO, SDS of cas: 884495-13-0.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Fritzemeier, Russell published the artcileDiscovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors, Recommanded Product: 4-Iodobenzohydrazide, the publication is Journal of Medicinal Chemistry (2022), 65(11), 7656-7681, database is CAplus and MEDLINE.

Sphingosine 1-phosphate (S1P) is a pleiotropic signaling mol. that interacts with five G-protein-coupled receptors (S1P1-5) to regulate cellular signaling pathways. S1P export is facilitated by Mfsd2b and spinster homolog 2 (Spns2). While mouse genetic studies suggest that Spns2 functions to maintain lymph S1P, Spns2 inhibitors are necessary to understand its biol. and to learn whether Spns2 is a viable drug target. Herein, we report a structure-activity relationship study that identified the first Spns2 inhibitor 16d (SLF1081851)(I). In vitro studies in HeLa cells demonstrated that 16d inhibited S1P release with an IC₅₀ of 1.93 μM. Administration of 16d to mice and rats drove significant decreases in circulating lymphocyte counts and plasma S1P concentrations, recapitulating the phenotype observed in mice made deficient in Spns2. Thus, 16d has the potential for development and use as a probe to investigate Spns2 biol. and to determine the potential of Spns2 as a drug target.

Journal of Medicinal Chemistry published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C7H7IN2O, Recommanded Product: 4-Iodobenzohydrazide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Dutra, Jason K. published the artcileFluorophosphonates on-Demand: A General and Simplified Approach toward Fluorophosphonate Synthesis, Safety of 1-Iodohexane, the publication is ChemBioChem (2021), 22(10), 1769-1774, database is CAplus and MEDLINE.

Herein, we report a general and simplified synthesis of fluorophosphonates directly from p-nitrophenylphosphonates. This FP on-demand reaction is mediated by a com. available polymer-supported fluoride reagent that produces a variety (25 examples) of fluorophosphonates in high yields while only requiring reagent filtration for pure fluorophosphonate isolation. This reaction protocol facilitates the rapid profiling of serine hydrolases with diverse and novel sets of activated phosphonates with differential proteome reactivity. Moreover, slight modification of the procedure into a reaction-to-assay format has enabled addnl. screening efficiency.

ChemBioChem published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tan, Derek S. published the artcileSynthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays, Synthetic Route of 101-29-1, the publication is Journal of the American Chemical Society (1999), 121(39), 9073-9087, database is CAplus.

(-)-Shikimic acid, was converted into both enantiomers of 2-hydroxyoxabicyclo[4.1.0]hept-3-ene-4-carboxylic acid which were attached to a solid support via a photocleavable linker. Tandem acylation-1,3-dipolar cycloaddition with nitrones yielded tetracyclic templates I. After development of several efficient coupling reactions of I and completion of extensive validation protocols, a split-pool synthesis yielded a binary encoded library calculated to contain 2.18 million polycyclic compounds These compounds are compatible with miniaturized cell-based forward chem. genetic assays designed to explore biol. pathways and reverse chem. genetic assays designed to explore protein function. As a simple illustration of the potential of these compounds, several were shown to activate a TGF-β-responsive reporter gene in mammalian cells.

Journal of the American Chemical Society published new progress about 101-29-1. 101-29-1 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Carboxylic acid,Ketone, name is 2-(3,5-Diiodo-4-oxopyridin-1(4H)-yl)acetic acid, and the molecular formula is C6H5NO, Synthetic Route of 101-29-1.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com