Month: November 2022

Wu, Zhao published the artcileDistal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis, Formula: C10H9IO4, the publication is Journal of the American Chemical Society (2020), 142(6), 2715-2720, database is CAplus and MEDLINE.

A distal-selective alkenyl C-H arylation method was reported through a directed palladium/norbornene (Pd/NBE) cooperative catalysis. An usage of appropriate combination of the directing group and the NBE cocatalyst was the key feature of this method. A range of acyclic and cyclic cis-olefins were suitable substrates and the reaction was operated under air with excellent site-selectivity. Preliminary mechanistic studies were consistent with the proposed Pd/NBE-catalyzed C-H activation instead of the Heck pathway. Initial success on distal alkylation was achieved using MeI and Me bromoacetate as electrophiles.

Journal of the American Chemical Society published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C7H11Br, Formula: C10H9IO4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Wu, Zhao published the artcilePalladium/norbornene-catalyzed distal alkenyl C-H arylation and alkylation of cis-olefins, Quality Control of 165534-79-2, the publication is Tetrahedron (2021), 132173, database is CAplus and MEDLINE.

In this full article, a detailed study of a distal alkenyl C-H arylation and alkylation through the palladium/norbornene (NBE) cooperative catalysis is described. Both aminopyridine- and oxime ether-type directing groups have been found effective for this transformation, allowing functionalization of diverse allyl amines and homoallyl alcs. In addition, the C5,C6-substituted NBEs show optimal reactivity and selectivity. Various cis-olefins can be transformed to the corresponding arylated or alkylated trisubstituted alkenes with excellent regio- and stereoselectivity. Preliminary mechanistic studies support the Catellani pathway instead of the Heck pathway.

Tetrahedron published new progress about 165534-79-2. 165534-79-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Benzene,Ester, name is Dimethyl 2-iodoterephthalate, and the molecular formula is C12H14BNO2, Quality Control of 165534-79-2.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ciapetti, Paola published the artcile2-Amino-4-bromobutanoic acid. A versatile reagent for the synthesis of nonnatural amino acids, Synthetic Route of 161370-66-7, the publication is Molecules Online [Electronic Publication] (1998), 2(2), 86-93, database is CAplus.

(2S)- and (2R)-2-Amino-4-bromobutanoic acid derivatives were prepared starting from Boc-L– and –D-Glu-OCMe₃. The double tert-Bu protection was necessary to prevent a partial racemization during the Barton radical decarboxylation used to transform the γ-carboxylic group into a bromide. This bromide reacted with different nitrogen, oxygen and sulfur nucleophiles to give nonnatural amino acids, e.g. I [R = piperidino, pyrrolidino, morpholino, pyrazolo, NH(CH₂)₁₅Me, NHC₆H₃(OMe)₂-2,5, OPh, iodo], characterized by basic or heterocyclic side chains. The title compound was also used to prepare conformationally constrained peptidomimetic II.

Molecules Online [Electronic Publication] published new progress about 161370-66-7. 161370-66-7 belongs to iodides-buliding-blocks, auxiliary class Chiral,Iodide,Amine,Aliphatic hydrocarbon chain,Ester,Amide, name is (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-iodobutanoate, and the molecular formula is C13H24INO4, Synthetic Route of 161370-66-7.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Abdullah, Mahmood M. S. published the artcileNew Amphiphilic Ionic Liquids for the Demulsification of Water-in-Heavy Crude Oil Emulsion, Safety of 1-Iodohexane, the publication is Molecules (2022), 27(10), 3238, database is CAplus and MEDLINE.

This work aimed to use abietic acid (AA), as a widely available natural product, as a precursor for the synthesis of two new amphiphilic ionic liquids (AILs) and apply them as effective demulsifiers for water-in-crude oil (W/O) emulsions. AA was esterified using tetraethylene glycol (TEG) in the presence of p-toluene sulfonic acid (PTSA) as a catalyst obtaining the corresponding ester (AATG). AATG was reacted with 1-vinylimidazole (VIM) throughout the Diels-Alder reaction, forming the corresponding adduct (ATI). Following this, ATI was quaternized using alkyl iodides, Et iodide (EI) and hexyl iodide (HI) to obtain the corresponding AILs, ATEI-IL and ATHI-IL, resp. The chem. structure, surface activity, thermal stability and relative solubility number (RSN) were investigated using different techniques. The efficiency of ATEI-IL and ATHI-IL to demulsify W/O emulsions in different crude oil: brine volumetric ratios were evaluated. ATEI-IL and ATHI-IL achieved promising results as demulsifiers. Their demulsification efficiency increased as the brine ratios decreased where their efficiency reached 100% at the crude oil: brine ratio (90:10), even at low concentrations

Molecules published new progress about 638-45-9. 638-45-9 belongs to iodides-buliding-blocks, auxiliary class Iodide,Aliphatic hydrocarbon chain, name is 1-Iodohexane, and the molecular formula is C6H13I, Safety of 1-Iodohexane.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Suzuki, Itaru published the artcileGaBr₃-catalyzed coupling between α-iodo esters with alkynylstannanes under UV irradiation, Synthetic Route of 31253-08-4, the publication is Chemistry Letters (2015), 44(1), 38-40/1-38-40/3, 3 pp., database is CAplus.

A coupling between various alkynylstannanes with α-iodo esters catalyzed by GaBr₃ under UV irradiation conditions has been described. A catalytic amount of GaBr₃ was essential, and a radical coupling with the generated alkynylgallium species was involved. The desired α-alkynyl esters were selectively obtained even in the presence of an aryl-I bond, which is a reactive site in a conventional palladium-catalyzed system.

Chemistry Letters published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is Al2H32O28S3, Synthetic Route of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Hedidi, Madani published the artcileSynthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells, HPLC of Formula: 1331850-50-0, the publication is Tetrahedron (2016), 72(41), 6467-6476, database is CAplus.

N-Arylation of pyrrole with 3-iodo-4-methoxypyridine was studied by copper catalysis under different conditions. The best conditions, that proved to be protocol A (CuI, DMEDA or TMEDA, K₃PO₄, DMF at 110°) and above all protocol B (Cu₂O, Cs₂CO₃, DMSO at 110°), were applied to the synthesis of various N-(methoxypyridyl) pyrroles, indoles and benzimidazoles. The behavior of the different iodinated methoxypyridines was rationalized by evaluating the partial pos. charge on the carbon bearing iodine from the ¹H NMR chem. shift of the corresponding deiodinated substrates. The reaction was next connected with the deprotometalation-iodolysis step generating iodinated methoxypyridines: straight involvement of the crude iodo intermediates in pyrrole N-arylation afforded the expected N-(methoxypyridyl) pyrroles in good yields. Several synthesized N-(methoxypyridyl) azoles exerted low to moderate antiproliferative activity in A2058 melanoma cells.

Tetrahedron published new progress about 1331850-50-0. 1331850-50-0 belongs to iodides-buliding-blocks, auxiliary class Pyridine,Iodide,Ether,Pyridine, name is 4-Iodo-3-methoxypyridine, and the molecular formula is C6H6INO, HPLC of Formula: 1331850-50-0.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ahmed I. published the artcileTheoretical and experimental spectroscopic investigation of new polymethine donor-π-acceptor cyanine dyes: Synthesis, photophysical, and TDDFT studies, Category: iodides-buliding-blocks, the publication is Journal of Molecular Structure (2018), 406-416, database is CAplus.

New series of polymethine cyanine dyes with different length of π-chain were synthesized and characterized. These new dyes are based on D-π-A architecture with long π-electron systems. The UV-visible/emission spectral studies showed that the dyes are absorbed in the region of λ_max (485-570) nm and emitted at (540-600) nm. This makes these dyes favorable for the detection of biol. and chem. analytes. Their electron cloud delocalization in HOMO/LUMO levels were studied by DFT using Gaussian 09 software. DFT results reveal that the dyes showed effective charge separation in its MOs levels, which reflected in its ICT behavior. Time-dependent d. functional theory (TD-DFT) were applied to theor. explored the first excitation energy (E_0-0) of these dyes which in high compatibility with exptl. results with an accuracy of 0.1-0.3 eV. This approach was successfully applied to describe the great effect of π-conjugation length and substituents of chromophore on the variations of maximum absorption and excitation energy of the dyes.

Journal of Molecular Structure published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Category: iodides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Koraiem, Ai published the artcileNovel cyanine dyes based on N-bridgehead heterobicyclic: synthesis, solvatochromism and physicochemical studies, HPLC of Formula: 606-55-3, the publication is Organic Chemistry: An Indian Journal (2018), 14(2), 125, database is CAplus.

Cyanine dyes of zero methine, monomethine, acyclic metro cyanine dyes incorporating pyrazolo (3,2-a) pyridine, payroll (3,4-c) pyrazolo (3,2-a) pyridine or quinolin (1,2-a) imidazo (2.3-c) pyrano (2,3-c) pyrazole and imidazo (1,2-a) quinoline resp. were synthesized and characterized by UV-Visible, elemental and spectral anal. The absorption spectra properties of such selected dyes were investigated in 95% ethanol to attempt and throw some light on the influence of such new heterocyclic nuclei and to compare or evaluate spectral behaviors. The solvatochromic behavior and color changes of some selected newly synthesized cyanine dyes are observed in solvents having different polarities. This permits a selection of optimal solvent (fractional solvent) when such dyes are applied as photosensitizers. The spectral behavior of some selected cyanine dyes in mixed solvents of different polarities has been studied to estimate number of hydrogen bond formed between the solute & solvent mols. and to allow measurement of certain energies such as hydrogen bonding, orientation and free energies.

Organic Chemistry: An Indian Journal published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, HPLC of Formula: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, Hassan Abazied published the artcileDicarbocyanine and tricarbocyanine dyes: Novel synthetic approaches, photosensitization evaluation and antimicrobial screening, SDS of cas: 606-55-3, the publication is Chemistry International (2020), 6(1), 30-41, database is CAplus.

Novel dicarbocyanine dyes (pentamethine cyanine dyes), bis dicarbocyanine dyes (bis pentamethine cyanine dyes), tricarbocyanine dyes (heptamethine cyanine dyes) and bis tricarbocyanine dyes (bis heptamethine cyanine dyes) derived from the nucleus of furo[(3,2-d)pyrazole; (3′,2′-d)oxazole] were prepared using novel synthetic approaches. The electronic visible absorption spectra were investigated in 95% ethanol to evaluate the photosensitization properties. The cyanine dyes were better photosensitizers in visible light to initiate the electronic transitions at higher wavelength bands (bathochromic shifted and/or red shifted dyes). Consequently, the photosensitization of the cyanine dyes decreases in visible light to initiate the electronic transitions at lower wavelength bands (hypsochromic shifted and/or blue shifted dyes). Antimicrobial activity of ten selected compounds was tested against four bacterial strains (Bacillus subtilis, Escherichia coli,Pseudomona aeruginosa and Staphylococcus aureus). The compounds were thought to be better antimicrobial active when they give higher inhibition zone against the tested strains. Consequently, the antimicrobial activity was promising and variable among all synthesized compounds against tested strains. Structural characterization and confirmations were determined by elemental anal., visible, mass, IR and ¹H NMR spectral data.

Chemistry International published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C14H21BO2, SDS of cas: 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shindy, Hassan Abazied published the artcileEffects of chemical structure, solvent and solution pH on the visible spectra of some new methine cyanine dyes, Quality Control of 606-55-3, the publication is European Journal of Chemistry (2014), 5(3), 451-456, 6 pp., database is CAplus.

Some new dimethine and bis-dimethine, cyanine dyes derived from benzo[2,3-b; 2′,3′-b’]bis-pyrazolo[4,5-b]-1,4-(oxa-, thia-, and pyra-)-zine-6,12-dione were synthesized. Effect of chem. structure on the electronic visible absorption spectra of all the synthesized cyanine dyes was investigated in 95% ethanol solution Effects of solvent and/or solution pH on the electronic visible absorption spectra of some selected synthesized cyanine dyes were also examined in pure solvents having different polarities and/or in aqueous universal buffer solutions, resp. Structural confirmations were carried out through elemental anal., mass spectroscopy, IR and ₁H NMR spectra.

European Journal of Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C6H20Cl2N4, Quality Control of 606-55-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com