Month: December 2022

Tsuboi, Sadao published the artcileNew synthesis of (±)-menthofuran, Recommanded Product: Ethyl 2-Iodopropionate, the publication is Journal of Organic Chemistry (1980), 45(8), 1517-20, database is CAplus.

(±)-Menthofuran [(±)-I] was prepared in 3 steps from Et 4-methyl- 2-oxo-1-cyclohexanecarboxylate (II) in a reasonable overall yield. Reaction of II with MeCHICO₂Et gave Et 2-(1-ethoxycarbonyl-4-methyl-2-oxocyclohexyl)propionate, which was converted directly to 3,6-dimethyl-2,4,5,6,7,7a-hexahydro-2-benzofuranone (III) by refluxing with concentrate HCl; reduction with LiAlH₄-Me₂CHOH at -60 to -50° gave (±)-I. The reduction of III at room temperature gave 2-(4-methyl-1-cyclohexenyl)-1,2-propanediol.

Journal of Organic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C17H14F3N3O2S, Recommanded Product: Ethyl 2-Iodopropionate.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Yoshida, Suguru published the artcileSingle C-F Bond Cleavage of Trifluoromethylarenes with an ortho-Silyl Group, Product Details of C7H3BrF3I, the publication is Angewandte Chemie, International Edition (2016), 55(35), 10406-10409, database is CAplus and MEDLINE.

The transformation of a single C-F bond of trifluoromethylarenes bearing a hydrosilyl group at the ortho position was achieved. The activation of the hydrosilyl group with a trityl cation in the presence of nucleophiles allowed for selective C-F bond functionalization, for example, by allylation, carboxylation, or chlorination. Further derivatization of the resulting fluorosilylarenes afforded various aromatic difluoromethylene compounds

Angewandte Chemie, International Edition published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C14H28O5S, Product Details of C7H3BrF3I.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Tominaga, Yoshinori published the artcileSynthesis of methylthiomaleimides for the preparation of pyridazines and related compounds, COA of Formula: C12H14IN, the publication is Journal of Heterocyclic Chemistry (2002), 39(3), 571-591, database is CAplus.

New functionalized maleimides [3-(methylthio)-2,5-dioxo-1H-pyrroles] were obtained by the reaction of ketene dithioacetals with nitromethane or the reaction of nitro ketene dithioacetal with active methylene compounds in the presence of the appropriate base in DMSO followed by treatment with methanol. These maleimides reacted with various nucleophilic reagents such as electron-rich aromatic and heteroaromatic compounds like dialkylanilines, aminophenols, indoles, indolizines, and cyclazines to give the corresponding 3-aryl- or -heteroaryl-1H-pyrrole-2,5-diones. Styryl and merocyanine dyes, and polycyclic pyridazinediones as chemiluminophors and succinimides were also obtained from these maleimides with good results.

Journal of Heterocyclic Chemistry published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C18H23N3O4S, COA of Formula: C12H14IN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Sakamoto, Takao published the artcileSynthesis and reaction of tributylstannylpyrazoles, Quality Control of 141998-77-8, the publication is Heterocycles (1992), 33(2), 813-18, database is CAplus.

1,3-Dipolar cycloaddition reaction of diazomethane and Et diazoacetate with tributylstannylacetylenes occurred regioselectively to afford the corresponding 3(5)-tributylstannylpyrazoles. The cycloaddition reaction of 3-phenylsydnone with the stannylacetylenes proceeded also regioselectively, and 3-tributylstannyl-1-phenylpyrazoles were isolated. 4-Tributylstannyl- and 5-tributylstannyl-1-phenylpyrazole were prepared by the stannylation of 4-lithio- and 5-lithio-1-phenylpyrazole with tributylstannyl chloride. Iodination, benzoylation, and phenylation of the stannylpyrazoles were examined

Heterocycles published new progress about 141998-77-8. 141998-77-8 belongs to iodides-buliding-blocks, auxiliary class Pyrazole,Iodide,Ester,Pyrazole, name is Ethyl 5-iodo-1H-pyrazole-3-carboxylate, and the molecular formula is C6H7IN2O2, Quality Control of 141998-77-8.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zhang, Ziyi published the artcileStudies on acylthiosemicarbazides and related heterocyclic derivatives. (XVII). Synthesis of 1-arylformyl-4-[4′-(2,2,6,6-tetramethylpiperidine)-1-oxy]thiosemicarbazide compounds, COA of Formula: C7H7IN2O, the publication is Gaodeng Xuexiao Huaxue Xuebao (1991), 12(8), 1056-60, database is CAplus.

Twenty-one title compounds I (R = Ph, pyridyl, 1-naphthyl, 2-phenyl-4-quinolyl, R¹C₆H₄; R¹ = 2-F, 3-F, 4-F, 2-Cl, 3-Cl, 4-Cl, 2-Br, 3-Br, 4-Br, 4-iodo, 4-Me, 3-Me, 2-MeO, 4-MeO, 2-NO₂, 3-NO₂, 4-NO₂) were prepared and characterized by IR, mass spectrometry, and ESR. Preliminary results show that I are inhibitors of L₇₇₁₂ leukemia cells.

Gaodeng Xuexiao Huaxue Xuebao published new progress about 39115-95-2. 39115-95-2 belongs to iodides-buliding-blocks, auxiliary class Iodide,Hydrazine,Amine,Benzene,Hydrazide,Amide, name is 4-Iodobenzohydrazide, and the molecular formula is C4H7BrO2, COA of Formula: C7H7IN2O.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Powell, D. B. published the artcileInfrared spectra and the stabilities of chelate metal-ethylenediamine complexes, Formula: C5H5ClIN, the publication is Journal of the Chemical Society (1961), 1112-14, database is CAplus.

cf. CA 54, 18078i. The suggestion that type A spectra are confined to complexes in which the ethylenediamine adapts the gauche configuration, while in the type B spectra the ligand has the cis configuration, has been abandoned because of x-ray studies. The spectra of PtCl₄^— salts of the ethylenediamine complex cations of Pt(II), Rh(III), Co(III), Pd(II), Cr(III), Hg(II), Cu(II), Ni(II), Co(II), Zn(II), and Cd(II) were studied. Frequencies of 2 bands assigned to N-H rocking and a band assigned to metal-N stretching decreased in the same order as the decrease in log K_av. The N-H rocking bands occur, 800-600 cm.^-1, while the metal-N stretching bands are at 585-478 cm.^-1.

Journal of the Chemical Society published new progress about 6443-90-9. 6443-90-9 belongs to iodides-buliding-blocks, auxiliary class Pyridines, name is Pyridine Iodochloride complex, and the molecular formula is C5H5ClIN, Formula: C5H5ClIN.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Lin, Shizhuo published the artcileLayered Double Hydroxides as Reusable Catalysts for Cyclocondensation of Amidines and Aminoalcohols: Access to Multi-functionalized Oxazolines, Computed Properties of 134322-01-3, the publication is Journal of Organic Chemistry (2022), 87(2), 1366-1376, database is CAplus and MEDLINE.

An efficient catalytic protocol based on reusable MgAl-layered double hydroxides has been developed for the synthesis of multi-functionalized oxazolines via the cyclocondensation of amidines and aminoalcs. The developed method has a broad substrate scope and excellent functional group tolerance and uses a reusable catalyst. The catalyst can be conveniently recycled by filtration and reused for at least five times without obvious deactivation. Addnl., the selective ortho C-H silylation of oxazolines was performed using Ru(II) as the catalyst and tri-Et silane as the silylating reagent, which proved to be a convenient and practical method for the synthesis of versatile organosilyl-functionalized oxazolines with advantageous biol. and phys. properties.

Journal of Organic Chemistry published new progress about 134322-01-3. 134322-01-3 belongs to iodides-buliding-blocks, auxiliary class Salt,Iodide,Amine,Amidine,Benzene, name is 4-Iodobenzimidamide hydrochloride, and the molecular formula is C7H8ClIN2, Computed Properties of 134322-01-3.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Aitov, I. A. published the artcileReaction of quinolinium salts with 2-cyano-2-(ethoxymethylene)acetanilide, Application of 1-Ethyl-2-methylquinolin-1-ium iodide, the publication is Zhurnal Organicheskoi Khimii (1994), 30(2), 291-4, database is CAplus.

Reaction of quinolinium halides I (R = Me, Et, allyl; R¹ = H, Me; X = I, Br) with EtOCH:C(CN)CONHPh (II) in the presence of Et₃N gave merocyanines III in 16-79% yield. Reaction of phenacylquinolinium bromides IV (R² = H, Cl, Br) with II gave merocyanines V and inner salts VI.

Zhurnal Organicheskoi Khimii published new progress about 606-55-3. 606-55-3 belongs to iodides-buliding-blocks, auxiliary class Quinoline,Salt, name is 1-Ethyl-2-methylquinolin-1-ium iodide, and the molecular formula is C12H14IN, Application of 1-Ethyl-2-methylquinolin-1-ium iodide.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Shi, Guangfa published the artcileSilver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent, Quality Control of 364-12-5, the publication is Organic Letters (2015), 17(1), 38-41, database is CAplus and MEDLINE.

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF₃· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions.

Organic Letters published new progress about 364-12-5. 364-12-5 belongs to iodides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Iodide,Benzene, name is 5-Bromo-2-iodobenzotrifluoride, and the molecular formula is C11H12O4, Quality Control of 364-12-5.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

McCaffery, E. L. published the artcilePolymetallophilic organic compounds. III. Competitive intramolecular Grignard coupling reactions, Application In Synthesis of 31253-08-4, the publication is Journal of Organometallic Chemistry (1972), 44(2), 227-31, database is CAplus.

Ring formation via an intramol. Grignard coupling reaction of trihalo alkanes is presented. 2-Methyl-2-(chloromethyl)-1,5-dichloropentane was prepared and treated with two equivalent Mg in THF to study the possible ring formation through 1,5 and/or 1,3 coupling reactions. A 1,3 Grignard coupling reaction was shown to occur preferentially, and a cyclopropane derivative I was formed. A 1,5 coupling reaction could not be realized under the prevailing reaction conditions. A diradical mechanism for the Grignard coupling reaction is proposed to account for the behavior of this compound and other similar polymetallophilic systems in their reaction with Mg.

Journal of Organometallic Chemistry published new progress about 31253-08-4. 31253-08-4 belongs to iodides-buliding-blocks, auxiliary class Iodide,Ester, name is Ethyl 2-Iodopropionate, and the molecular formula is C5H9IO2, Application In Synthesis of 31253-08-4.

Referemce:
https://en.wikipedia.org/wiki/Iodide,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com