Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors was written by Belov, Dmitry S.;Ivanov, Vladimir N.;Curreli, Francesca;Kurkin, Alexander V.;Altieri, Andrea;Debnath, Asim K.. And the article was included in Synthesis in 2017.Computed Properties of C8H9IO2 This article mentions the following:
5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Herein, a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids, e.g., I, in three steps starting from pyrrole is presented. By this method, the compounds could be prepared on gram scale and without chromatog. purification In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Computed Properties of C8H9IO2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Computed Properties of C8H9IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com