Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma was written by Desbois, Nicolas;Gardette, Maryline;Papon, Janine;Labarre, Pierre;Maisonial, Aurelie;Auzeloux, Philippe;Lartigue, Claire;Bouchon, Bernadette;Debiton, Eric;Blache, Yves;Chavignon, Olivier;Teulade, Jean-Claude;Maublant, Jean;Madelmont, Jean-Claude;Moins, Nicole;Chezal, Jean-Michel. And the article was included in Bioorganic & Medicinal Chemistry in 2008.Electric Literature of C7H6INO2 This article mentions the following:
Various iodo-acridone and acridine carboxamides have been prepared and evaluated as agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural similarity to benzamides which are known to possess specific affinity for melanin. Three of these carboxamides selected for their in vitro cytotoxic properties were radioiodinated with [125I]NaI at high specific activity. Biodistribution studies carried out in B16F0 murine melanoma tumor-bearing mice highlighted that acridone 8f and acridine 9d, presented high, long-lasting tumor concentrations together with an in vivo kinetic profile favorable to application in targeted radionuclide therapy. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Electric Literature of C7H6INO2).
2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C7H6INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com