Synthesis of unsymmetrical biaryl ketones via palladium-catalyzed carbonylative cross-coupling reaction of arylboronic acids with iodoarenes was written by Ishiyama, Tatsuo;Kizaki, Hiroe;Miyaura, Norio;Suzuki, Akira. And the article was included in Tetrahedron Letters in 1993.HPLC of Formula: 36748-88-6 This article mentions the following:
The cross-coupling reaction between arylboronic acids, CO (1 atm), and aryl iodides in the presence of palladium catalyst and base provided unsym. biaryl ketones in high yields. Thus, PdCl2(CH3CN)2 catalyzed carbonylative cross-coupling reaction of PhB(OH)2 with 4-IC6H4NO2 in anisole containing K2CO3 and CO gave 89% PhCOC6H4NO2-4. The choice of a suitable base and solvent was essential to achieve selective formation of the unsym. biaryl ketone without a biaryl byproduct. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6HPLC of Formula: 36748-88-6).
3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.HPLC of Formula: 36748-88-6
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com