Palladium-Catalyzed Intramolecular Heck/Aminocarbonylation of Alkene-Tethered Iodobenzenes with Nitro Compounds: Synthesis of Carbamoyl-Substituted Benzoheterocycles was written by Kang, Yun;Lu, Jin-Liang;Zhang, Zhi;Liang, Ying-Kang;Ma, Ai-Jun;Peng, Jin-Bao. And the article was included in Journal of Organic Chemistry.Application of 207115-22-8 This article mentions the following:
A palladium-catalyzed intramol. Heck/aminocarbonylation of alkene-tethered iodobenzenes 2-I-4-R-5-R1-C6H2XCH2C(CH3)=CH2 [R = H, F, Cl, Me, etc.; R1 = H, Cl, OMe, C(O)OMe; X = O, NMe, NBn, NTs] with nitro compounds R2NO2 (R2 = Me, Ph, naphthalen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) has been developed for the synthesis of carbamoyl substituted benzoheterocycles I. Using Mo(CO)6 as a solid CO source, no external reductant or additives were needed in this procedure. Both nitroarenes and nitroalkanes were well tolerated. A range of carbamoyl-substituted dihydrobenzofurans I (X = O) and indolines I (X = NMe, NBn, NTs) were prepared in moderate to high yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Application of 207115-22-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com