Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[c]quinolin-3-ones and benzo[b]azocin-2-ones was written by Li, Qiao;Cai, Yun;Hu, Yuanyuan;Jin, Hongwei;Chen, Fener;Liu, Yunkui;Zhou, Bingwei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Recommanded Product: 4,5-Dichloro-2-iodoaniline This article mentions the following:
A nickel-catalyzed cyclization of N-(o-ethynylaryl)acrylamides for selective syntheses of dihydrocyclobuta[c]quinolin-3-ones I [R1 = Ph, 2-MeOC6H4, 4-ClC6H4, etc.; R2 = H, Me, Ph; R3 = Me, Et, Bn, methoxymethyl; R4 = H, 7-Me, 6-Cl, etc.] and benzo[b]azocin-2-ones II [R5 = Ph, 4-MeC6H4, 3-thienyl, etc.; R6 = H, Me, Ph; R7 = Me, Bn, methoxymethyl; R8 = H, 8-Me, 8-CN, etc.] was reported. The two varied products I and II could be easily obtained by tuning the reaction temperature This reaction featured easy temperature-control, high efficiency and gram-scale synthesis. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Recommanded Product: 4,5-Dichloro-2-iodoaniline).
4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Recommanded Product: 4,5-Dichloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com