Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation was written by Oslob, Johan D.;Johnson, Russell J.;Cai, Haiying;Feng, Shirley Q.;Hu, Lily;Kosaka, Yuko;Lai, Julie;Sivaraja, Mohanram;Tep, Samnang;Yang, Hanbiao;Zaharia, Cristiana A.;Evanchik, Marc J.;McDowell, Robert S.. And the article was included in ACS Medicinal Chemistry Letters in 2013.Formula: C8H7IO2 This article mentions the following:
Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochem. activities. The most potent analog (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Formula: C8H7IO2).
3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Formula: C8H7IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com