Metal-Free Hypervalent-Iodine-Promoted C3 Difluorination and C2 Oxidation of N-Substituted Indoles was written by Sun, Xin;Zhao, Xiao-Jing;Wu, Bin. And the article was included in Asian Journal of Organic Chemistry in 2017.Computed Properties of C8H7IO4 This article mentions the following:
A metal-free, highly regioselective C3 difluorination and C2 oxidation of N-substituted indoles I (R1 = 5-Br, 7-Cl, 3,6-F2, etc.; R2 = Bn, 4-ClC6H4CH2, 2,3,5-F3C6H2CH2, etc.) with the aid of in situ generated PhIF2 in the presence of two types of fluorinating agents such as Pyr·HF and Et3N·HF was reported. This reaction provided 3,3-difluoro-2-oxindoles II with yields up to 64% under mild reaction conditions. A mechanism for this reaction was proposed. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Computed Properties of C8H7IO4).
Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Computed Properties of C8H7IO4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com