Electronically unfavorable addition of electron-deficient olefins to isochromenylium tetrafluoroborates initiated by C-1 O-glycosylation was written by Yu, Shu-Yan;Hu, Zhi-Long;Zhang, Hao;Wang, Shaozhong;Yao, Zhu-Jun. And the article was included in Tetrahedron Letters in 2012.Application In Synthesis of 4-Bromo-2-iodophenol This article mentions the following:
Electronically unfavorable reactions between isochromenylium tetrafluoroborates, e.g. I, and electron-deficient olefins have been studied and achieved by assistance of a phenolic hydroxyl group in the olefin substrates, providing the corresponding 2-oxabicyclo[3.3.1]nonane derivatives, e.g. II, diastereoselectively in moderate to satisfactory yields. The new methodol. is initiated by an intermol. C-1 O-glycosylation, and completed with an intramol. Michael addition and an aldol condensation in cascade fashion. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application In Synthesis of 4-Bromo-2-iodophenol).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Application In Synthesis of 4-Bromo-2-iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com