Development and preclinical evaluation of new 124I-folate conjugates for PET imaging of folate receptor-positive tumors was written by AlJammaz, I.;Al-Otaibi, B.;Al-Rumayan, F.;Al-Yanbawi, S.;Amer, S.;Okarvi, S. M.. And the article was included in Nuclear Medicine and Biology in 2014.Related Products of 58481-10-0 This article mentions the following:
In an attempt to develop new folate radiotracers with favorable biochem. properties for detecting folate receptor-pos. cancers, we have synthesized [124I]-SIB- and [124I]-SIP-folate conjugates using a straightforward and two-step simple reactions. Radiochem. yields for [124I]-SIB- and [124I]-SIP-folate conjugates were greater than 90 and 60% resp., with total synthesis time of 30-40 min. Radiochem. purities were always greater than 98% without HPLC purification These synthetic approaches hold considerable promise as rapid and simple method for 124I-folate conjugate preparation with high radiochem. yield in short synthesis time. In vitro tests on KB cell line showed that the significant amounts of the radioconjugates were associated with cell fractions. In vivo characterization in normal Balb/c mice revealed rapid blood clearance of these radioconjugates and favorable biodistribution profile for [124I]-SIP-folate conjugate over [124I]-SIB-folate conjugate. Biodistribution studies of [124I]-SIP-folate conjugate in nude mice bearing human KB cell line xenografts, demonstrated significant tumor uptake. The uptake in the tumors was blocked by excess injection of folic acid, suggesting a receptor-mediated process. These results demonstrate that [124I]-SIP-folate conjugate may be useful as a mol. probe for detecting and staging of folate receptor-pos. cancers, such as ovarian cancer and their metastasis as well as monitoring tumor response to treatment. In the experiment, the researchers used many compounds, for example, 2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0Related Products of 58481-10-0).
2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Related Products of 58481-10-0
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com