Synthesis of 1-Substituted Fluorenones was written by George, Stephen R. D.;Scott, Lawrence T.;Harper, Jason B.. And the article was included in Polycyclic Aromatic Compounds in 2016.Synthetic Route of C7H4ClIO2 This article mentions the following:
A convenient and scalable synthesis of a range of 1-substituted fluorenones I (X = F, Cl, OCH3, CONH2, etc.) from readily available starting materials is described. Through the use of either a Suzuki process, benzyne chem., or the Hoffmann rearrangement, a range of different 1-substituted fluorenones (fluoro, chloro, bromo, iodo, methoxy, cyano, amino, Ph, and hydroxy) were prepared on a multigram scale using robust and readily reproducible chem. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Synthetic Route of C7H4ClIO2).
2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Synthetic Route of C7H4ClIO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com