N3-Substituted thymidine analogues. Part III: radiosynthesis of N3-[(4-[18F]fluoromethyl-phenyl)butyl]thymidine ([18F]-FMPBT) and N3-[(4-[18F]fluoromethyl-phenyl)pentyl] thymidine ([18F]-FMPPT) for PET was written by Ghosh, Pradip;Gelovani, Juri G.;Alauddin, Mian M.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2007.Reference of 10297-05-9 This article mentions the following:
Radiosyntheses of two N3-substituted thymidine analogs, N3-[(4-[18F]fluoromethyl-phenyl)butyl- and -pentyl]thymidine ([18F]FMPBT and [18F]FMPPT, resp.), are reported. The precursor compounds, tetrahydropyranyl ether-protected chloromethyl compounds, were synthesized in six steps and the unlabeled standard compounds were synthesized from these precursors. For radiosynthesis, the precursors were fluorinated with Bu4N[18F] and subsequently hydrolyzed by acid. The crude products were purified by HPLC to obtain [18F]FMPBT and [18F]FMPPT. The average decay-corrected radiochem. yield for [18F]FMPBT was 15% in 5 runs, and that for [18F]FMPPT was 10% in 4 runs. The radiochem. purity was >99% and the specific activity was >74 GBq/μmol at the end of synthesis. The synthesis time was 80-90 min from the end of bombardment. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Reference of 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Reference of 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com