B-Ring-Modified isoCombretastatin A-4 Analogues Endowed with Interesting Anticancer Activities was written by Hamze, Abdallah;Rasolofonjatovo, Evelia;Provot, Olivier;Mousset, Celine;Veau, Damien;Rodrigo, Jordi;Bignon, Jerome;Liu, Jian-Miao;Wdzieczak-Bakala, Joanna;Thoret, Sylviane;Dubois, Joelle;Brion, Jean-Daniel;Alami, Mouad. And the article was included in ChemMedChem in 2011.Category: iodides-buliding-blocks This article mentions the following:
A novel class of isocombretastatin A-4 (isoCA-4) analogs with modifications at the 3′-position of the B-ring by replacement with C-linked substituents was studied. Exploration of the structure-activity relationships of theses analogs led to the identification of several compounds that exhibit excellent antiproliferative activities in the nanomolar concentration range against H1299, MDA-MB231, HCT116, and K562 cancer cell lines; they also inhibit tubulin polymerization with potency similar to that of isoCA-4. 1,1-Diarylethylenes 8 and 17, resp. with (E)-propen-3-ol and propyn-3-ol substituents at the 3′-position of the B-ring, proved to be the most active in this series. Both compounds led to the arrest of various cancer cell lines at the G2/M phase of the cell cycle and strongly induced apoptosis. Docking of compounds 8 and 17 in the colchicine binding site indicated that their C3′ substituents guide the positioning of the B-ring in a manner different from that observed for isoCA-4. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Category: iodides-buliding-blocks).
3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com