Synthesis of marine sponge alkaloid hachijodine B and a comment on the structure of ikimine B and on the absolute configuration of niphatesine D was written by Romeril, Stuart P.;Lee, Victor;Baldwin, Jack E.. And the article was included in Tetrahedron Letters in 2004.Formula: C4H8ClI This article mentions the following:
The syntheses of the proposed structures of hachijodine B (I; R = CH2NHOMe), ikimine B (I; R = CH=NOMe) and niphatesine D (I; R = CH2NH2) from S-citronellol are described. Our results suggest that the gross structures of hachijodine B and niphatesine D are correct, but that ikimine B was incorrectly assigned. The authors have also established that the previous absolute stereochem. assignment for niphatesine D is unreliable. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Formula: C4H8ClI).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Formula: C4H8ClI
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com