F– Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes was written by Tang, Hai-Jun;Zhang, Yu-Feng;Jiang, Yi-Wen;Feng, Chao. And the article was included in Organic Letters in 2018.Quality Control of (5-Fluoro-2-iodophenyl)methanol This article mentions the following:
An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes, e.g., I. The success of this strategy hinged upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same mol., as well as a smooth transmetalation step, which delicately joined together these two different metallic intermediates. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2Quality Control of (5-Fluoro-2-iodophenyl)methanol).
(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Quality Control of (5-Fluoro-2-iodophenyl)methanol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com