Visible-Light-Enabled Ph3P/LiI-Promoted Tandem Radical Trifluoromethylation/Cyclization/Iodination of 1,6-Enynes with Togni’s Reagent was written by Liu, Hui;Fan, Xu;Hu, Jinkai;Ma, Tongtong;Wang, Feng;Yang, Jinhui;Li, Dianjun. And the article was included in Journal of Organic Chemistry in 2022.Application of 207115-22-8 This article mentions the following:
The visible-light-induced Ph3P/LiI-promoted intermol. cascade trifluoromethyl radical addition/5-exo-dig cyclization/iodination of 1,6-enynes R1CCCH2XCH2C(R2)=CH2 [R1 = 4-chlorophenyl, thiophen-2-yl, naphthalen-1-yl, etc.; R2 = H, Me, Ph, COOEt; X = O, N(Ts), N(Boc)]/2-CCR3C6H5-4-R4C6H3OCH=CH2 (R3 = H, 4-Me, 3-Cl 4-Br, etc.; R4 = H, Me, Br) with Togni’s reagent using LiI as the iodine source without the need of the transition metal, oxidant, and base were reported. This reaction promises to be a useful method for the preparation of trifluoromethyl-substituted and vinyl C-I bond-containing pyrrolidines I and benzofuran products II with good regioselectivity and functional-group tolerance under ambient conditions. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application of 207115-22-8).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Application of 207115-22-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com