Catalytic Asymmetric Homologation of α-Ketoesters with α-Diazoesters: Synthesis of Succinate Derivatives with Chiral Quaternary Centers was written by Li, Wei;Liu, Xiaohua;Tan, Fei;Hao, Xiaoyu;Zheng, Jianfeng;Lin, Lili;Feng, Xiaoming. And the article was included in Angewandte Chemie, International Edition in 2013.Product Details of 10297-05-9 This article mentions the following:
In the presence of Y(OTf)3 and proline- or pipecolic acid-derived N,N’-dioxide ligand, the first catalytic asym. homologation of α-ketoesters R1C(O)CO2Me (R1 = Me, Ph, 3-MeC6H4, 4-H2C:CHC6H4, piperonyl, 2-naphthyl, etc.) with α-diazo esters R2C(N2)CO2Ad [Ad = 1-adamantyl; R2 = Me, Et, n-decyl, H2C:CHCH2, HCCHCH2, N3(CH2)3, etc.] through either a 1,2-aryl or 1,2-alkyl shift was accomplished. Highly functionalized succinate derivatives MeO2CC(O)CR1R2CO2Ad containing a quaternary stereocenter were obtained in excellent yields and with good enantioselectivities under mild conditions. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Product Details of 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Product Details of 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com