Study on synthesis of 2-chloro-5-trifluoromethyl pyridine-4-yl-boronic acid was written by Liu, Guoquan;Wang, Shanshan;Liang, Jiudi;Li, Qiuwu;Han, Jianrong. And the article was included in Hebei Keji Daxue Xuebao in 2014.Formula: C6H2ClF3IN This article mentions the following:
2-Chloro-5-trifluoromethyl pyridine-4-yl-boronic acid was prepared with 2-chloro-4-iodo-5-trifluoromethyl pyridine as the raw material through reaction with Bu lithium reagent. Several reaction conditions of the synthesis process were studied through the experiment The purity and structure of the products were characterized by HPLC, FTIR and 1H NMR. Exptl. result shows that when the temperature is -70°C, the reaction time is 2h, the molar ratio of n(C6H2ClF3IN):n(C12H27BO3):n(C4H9Li)is=1.00:1.20:1.20, and the pH is 9.0, the yield of 2-chloro-5-trifluoromethyl pyridine-4-yl-boronic acid reaches 83.10%, and its purity is up to 98.65%. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Formula: C6H2ClF3IN).
2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C6H2ClF3IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com