Reference of 112671-42-8,Some common heterocyclic compound, 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, molecular formula is C6H3BrINO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(4) Add 42g (100mmol) of M3 to the reaction flask,2-iodo-5-bromonitrobenzene (110mmol),Tetratriphenylphosphine palladium 0.9g (0.785mmol, 0.5%),500mL of toluene, 200mL of ethanol,200mL of water and 40g (300mmol) of potassium carbonate, react at 100 for 8h;After the reaction is complete, stop the reaction; cool to room temperature, concentrate, and silica gel column chromatography to obtain white powder M4;
The synthetic route of 112671-42-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yantai Xianhua Chemical Technology Co., Ltd.; Xing Qifeng; Feng Peichuan; Chen Yue; Hu Lingfeng; Chen Yili; (27 pag.)CN111004241; (2020); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com