As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 624-75-9 name is 2-Iodoacetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 624-75-9
benzoic acid (0.25 mmol, 30.6 mg), PhCH2CH2CH(Bpin) 2 (0.375 mmol, 139.8 mg) was added to a sealed tube.The reaction tube was replaced with a nitrogen atmosphere, and then 2 mL of tetrahydrofuran was added.The reaction tube was placed at -30 C under a nitrogen atmosphere.Add methyl lithium (0.625mmol, 1.6mol/L in Et2O), stir for 5min, then reverseIt should be placed in a pot at 100 C for 8 h. Subsequently, p-methoxybenzyl chloride (0.5 mmol, 78.3 mg) was added to the reaction tube under a nitrogen atmosphere, and the reaction was continued at 100 C for 6 h. At the end of the reaction, water and ethyl acetate were added for extraction, and the product was obtained by column chromatography to give a yield of 90%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Iodoacetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Chinese Academy Of Sciences Lanzhou Chemical Physics Institute Suzhou Institute; Liu Chao; Sun Wei; Wang Lu; (61 pag.)CN108373398; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com