Electric Literature of 31599-61-8,Some common heterocyclic compound, 31599-61-8, name is 4-Iodo-1,2-dimethylbenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 3,4-Dimethyl iodobenzene (0.10 mol) was dissolved in xylene (200 mL), and bistriphenylphosphine palladium dichloride was added.(0.0005 mol) and tert-butyl potassium (0.20 mol), after stirring, 3-aminopentane (0.11 mol) was added, the reaction temperature was adjusted to 90 C, and the reaction was carried out for 6 hr. After the reaction, the mixture was cooled to room temperature, and filtered. 100 ml of 5% aqueous citric acid solution, 100 ml of saturated sodium carbonate solution,Wash with 100 ml of saturated brine and dry over anhydrous sodium sulfate.The mixture was concentrated under reduced pressure until the liquid surface was not foamed to afford 18.4 g of an oily product. The product yield was 96.3% based on 3,4-dimethyl iodobenzene, and the purity was determined by HPLC to be 96.8 %.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1,2-dimethylbenzene, its application will become more common.