Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 696-41-3, name is 3-Iodobenzaldehyde, A new synthetic method of this compound is introduced below., Computed Properties of C7H5IO
Triethyl phosphonoacetate (9.21 g, 41.12 mmol) in tetrahydrofuran (65 mL) was treated with 2.5 M n-butyl lithium in hexanes (12.82 mL, 32.07 mmol) at -78 C. The resulting mixture was stirred for 10 min and added via a cannula to a pre-cooled solution at -78 C of 3-iodobenzaldehyde (4.77 g, 20.56 mmol) in tetrahydrofuran (20 mL). The resulting mixture was stirred at -78 C for 40 min and slowly warmed to ambient temperature for 45 min. The reaction was quenched with saturated aqueous NH4Cl (200 mL). The aqueous solution was extracted with diethyl ether. The resulting organic layer was dried over magnesium sulfate and evaporated. The residue was purified by silica gel chromatography (90:10 hexanes/ethyl acetate) to give 5.71 g (92%) of compound 1a as a yellow oil; 1H NMR (CDCl3) delta 1.32 (t, J = 7.1 Hz, 3H); 4.24 (q, J = 7.1 Hz, 2H); 6.39 (d, J = 16.0 Hz, 1H); 7.09 (dd, J = J’ = 7.8 Hz, 1H); 7.43-7.46 (m, 1H); 7.54 (d, J = 16.0 Hz, 1H); 7.64-7.69 (m, 1H); 7.83-7.86 (m, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Fabio, Karine; Guillon, Christophe; Lacey, Carl J.; Lu, Shi-Fang; Heindel, Ned D.; Ferris, Craig F.; Placzek, Michael; Jones, Graham; Brownstein, Michael J.; Simon, Neal G.; Bioorganic and Medicinal Chemistry; vol. 20; 3; (2012); p. 1337 – 1345;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com