Some common heterocyclic compound, 127654-70-0, name is 1-Chloro-3-fluoro-2-iodobenzene, molecular formula is C6H3ClFI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Chloro-3-fluoro-2-iodobenzene
Step 22-Chloro-6-fluoro-iodbenzene (10 g, 39 mmol) is dissolved in sulfuric acid (cone, 17 ml_) at 0 C. A mixture of nitric acid (cone, 3.2 ml_) and sulfuric acid (cone, 3.2 ml_) is added at 0 C and stirring is continued for 2 h at 25 C. The reaction mixture is pourred onto ice. The resulting precipitate is collected, dried and used without further purification for the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 127654-70-0, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STADTMUELLER, Heinz; WO2012/104388; (2012); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com