《Alkanethiols Mediated Cyclization of o-Alkynylisocyanobenzenes: Synthesis of bis-Thiolated Indole Derivatives》 was published in Journal of Organic Chemistry in 2020. These research results belong to La-ongthong, Kannika; Naweephattana, Phiphop; Khaikate, Onnicha; Surawatanawong, Panida; Soorukram, Darunee; Pohmakotr, Manat; Reutrakul, Vichai; Leowanawat, Pawaret; Kuhakarn, Chutima. Application In Synthesis of 4-Chloro-2-iodoaniline The article mentions the following:
Reactions of o-alkynylisocyanobenzenes with a variety of alkanethiols (Alk-SH) provided the corresponding bis-thiolated indole derivatives The merits of the reaction include metal-free, room temperature, mild reaction conditions and broad functional group compatibility. The reaction proceeded via nucleophilic addition of the alkanethiol to an isonitrile moiety, 5-exo cyclization, followed by nucleophilic addition of alkanethiol to a 3-alkylideneindole intermediate. D. functional calculations on the electronic structures and relative free energies of 5-exo and 6-endo cyclization pathways supported that the 5-exo cyclization was preferable. After reading the article, we found that the author used 4-Chloro-2-iodoaniline(cas: 63069-48-7Application In Synthesis of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Application In Synthesis of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com