《Palladium-catalyzed three-component carbonylative synthesis of 2-(trifluoromethyl)quinazolin-4(3H)-ones from trifluoroacetimidoyl chlorides and amines》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Chen, Zhengkai; Wang, Le-Cheng; Zhang, Jiajun; Wu, Xiao-Feng. Quality Control of 4-Chloro-2-iodoaniline The article mentions the following:
A palladium-catalyzed three-component carbonylative reaction of trifluoroacetimidoyl chlorides and amines for the synthesis of valuable 2-(trifluoromethyl)quinazolin-4(3H)-ones was developed. Broad substrate scope (41 examples), high efficiency (up to 99% yield) and no manipulation of CO gas constituted the notable features of this reaction. The present strategy was applied to the late-stage modification of natural mols. and to the synthesis of the bioactive alkaloid mol. rutaecarpine. The results came from multiple reactions, including the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Quality Control of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Quality Control of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com