In 2022,Zhang, Enshen; Chen, Chen; Wang, Xueling; Wang, Jian; Shang, Yongjia published an article in Organic Chemistry Frontiers. The title of the article was 《Palladium-catalyzed dearomative 1,4-arylmethylenation of naphthalenes》.Quality Control of 4-Chloro-2-iodoaniline The author mentioned the following in the article:
An efficient palladium-catalyzed construction of E-exocyclic-double-bond-containing spirooxindoles via 1,4-arylmethylenation of naphthalenes has been developed. Aryl aldehyde-derived N-tosylhydrazones were successfully applied as carbene precursors to capture the endocyclic π-allylpalladium intermediate, which was generated via an arylative Heck reaction of the naphthalene-masked conjugated diene, followed by a highly regioselective β-hydride elimination. This reaction features broad functional group tolerance and excellent chemo- and E/Z selectivities. The experimental process involved the reaction of 4-Chloro-2-iodoaniline(cas: 63069-48-7Quality Control of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com