Sun, Mingjie; Chen, Xinyang; Feng, Zichao; Deng, Guobo; Yang, Yuan; Liang, Yun published their research in Organic Chemistry Frontiers in 2021. The article was titled 《A Catellani and retro-Diels-Alder strategy to access 1-amino phenanthrenes via ortho- and interannular C-H activation of 2-iodobiphenyls》.SDS of cas: 63069-48-7 The article contains the following contents:
An efficient palladium-catalyzed three-component domino reaction of 2-iodobiphenyls, O-benzoylhydroxylamines and dienes was developed to construct diverse 1-amino phenanthrene derivatives I [R1 = H, 2-Me, 3-Cl, etc.; R2 = H, 7-F, 5-Cl, etc.; R3 = Et; R4 = Et; R3R4 = morpholin-4-yl, pyrrolidin-1-yl, thiomorpholin-4-yl, etc.]. The methodol. realized simultaneous construction of one C-N bond and two C-C bonds via a Catellani and retro-Diels-Alder strategy by ortho- and interannular C-H activation of 2-iodobiphenyls. Furthermore, this methodol. featured good functional group tolerance and broad substrate scope. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodoaniline(cas: 63069-48-7SDS of cas: 63069-48-7)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 63069-48-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com