Enantioselective, Catalytic Vicinal Difluorination of Alkenes was written by Scheidt, Felix;Schaefer, Michael;Sarie, Jerome C.;Daniliuc, Constantin G.;Molloy, John J.;Gilmour, Ryan. And the article was included in Angewandte Chemie, International Edition in 2018.Safety of Methyl 3,5-dihydroxy-4-iodobenzoate This article mentions the following:
An efficient method was developed for the synthesis of 1,2-difluoroethyl arenes ArCH(F)CH2F [Ar = 3-CNC6H4, 4-O2NC6H4, 2-SO2MeC6H4, etc.] via enantioselective II/IIII catalytic vicinal difluorination of terminal alkenes using novel C2-sym. resorcinol derivative Catalyst turnover via in situ generation of an ArIIIIF2 species was enabled by Selectfluor oxidation and addition of an inexpensive HF-amine complex. The HF:amine ratio employed in this process provided a handle for regioselective orthogonality as a function of Bronsted acidity. Selectivity reversal from the 1,1-difluorination pathway (geminal) to the desired 1,2-difluorination (vicinal) was disclosed (>20:1 in both directions). An achiral variant of the reaction was also presented using p-iodotoluene (up to >95 % yield). In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Safety of Methyl 3,5-dihydroxy-4-iodobenzoate).
Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of Methyl 3,5-dihydroxy-4-iodobenzoate
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com