An N-Acyliminium Cyclization Approach to a Total Synthesis of (+)-Cylindricine C was written by Liu, Jia;Swidorski, Jacob J.;Peters, Scott D.;Hsung, Richard P.. And the article was included in Journal of Organic Chemistry in 2005.Related Products of 10297-05-9 This article mentions the following:
Details of problems and solutions encountered during the development of an enantioselective total synthesis of (+)-cylindricine C (I) are described here. The total synthesis itself was accomplished in 8 steps, featuring an N-acyliminium cyclization strategy, the seldom-used Wharton rearrangement, and a key epimerization at C5. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Related Products of 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Related Products of 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com