Catalytic Enantioselective α-Alkylation of Amides by Unactivated Alkyl Electrophiles was written by Tong, Xiaoyu;Schneck, Felix;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2022.SDS of cas: 10297-05-9 This article mentions the following:
Herein the achievement of this objective, demonstrating that a nickel catalyst could accomplish enantioselective intermol. alkylations of racemic Reformatsky reagents with unactivated electrophiles; the resulting α-alkylated carbonyl compounds could be converted in one addnl. step into a diverse array of ubiquitous families of chiral mols was described. Applying a broad spectrum of mechanistic tools, have gained insight into key intermediates (including the alkylnickel(II) resting state) and elementary steps of the catalytic cycle. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 10297-05-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com