Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)-H bonds with aryl halides was written by Li, Mingliang;Dong, Jiaxing;Huang, Xiaolei;Li, Kaizhi;Wu, Qian;Song, Feijie;You, Jingsong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.SDS of cas: 77350-52-8 This article mentions the following:
In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp3)-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. E.g., in presence of a Ni catalyst, arylation of 8-quinolinyl-substituted amide I with 4-IC6H4OMe gave 83% II. The best results were obtained by using Ni(OTf)2 as the catalyst, PPh3 as the ligand, Na2CO3 as the base, PivOH, and DMSO as the additives in dry 1,4-dioxane at 160 °C. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp3)-H bond arylation. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).
N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.SDS of cas: 77350-52-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com