Synthesis, configuration judgment and potentiation activity of (2S,3S,E)-4-(3,4- dihydroxybenzylidene)-3-(3,4-dihydroxyphenyl)- 5-oxotetrahydrofuran-2-carboxylic acid was written by Zhang, Jun-Liang;Lv, Zhi-Liang;Zhong, Jia-Liang;Chen, Dai-Jie;Li, Mo-Ying;Zhang, Jian-Bin. And the article was included in Chinese Journal of Structural Chemistry in 2017.Formula: C8H9IO2 This article mentions the following:
The title compound (2S,3S,E)-4-(3,4-dihydroxybenzylidene)-3-(3,4-dihydroxyphenyl)- 5-oxotetrahydrofuran-2-carboxylic acid was synthesized and the 2D structure was characterized by 1H-NMR 13C-NMR and LCMS. The absolute configuration was determined by single-crystal X-ray diffraction of the key intermediate (2S,3S,E)-Et 4-(3,4-dimethoxybenzylidene)- 3-(3,4-dimethoxyphenyl)-5-oxotetrahydrofuran-2-carboxylate. The crystal belongs to tetragonal system, space group P41 with a = 13.0665(2), b = 13.0665(2), c = 13.4735(2) Å, V = 2300.4(6) Å3, Z = 4, Dc = 1.278 g/cm3, μ(CuKa) = 0.801 mm-1, F(000) = 936, S = 1.050, R = 0.0364 and wR (I > 2s(I)) = 0.1071. X-ray diffraction results showed that the mol. structure is stabilized totally by Van der Waals force. The antibacterial activity tests showed that the title compound possesses slight synergistic effect against MRSA and Acinetobacter baumanii. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C8H9IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com