Palladium-Catalyzed Enantioselective Cyclization of 1,6-Enynes through Intramolecular Chlorine Transfer as a Novel Strategy for Asymmetric Halopalladation was written by Tang, Junlong;Zhang, Liren;Wu, Wanqing;Yang, Shaorong;Jiang, Huanfeng. And the article was included in Chemistry – A European Journal.Electric Literature of C8H5IS This article mentions the following:
Herein, an intramol. chlorine transfer strategy is used to accomplish the enantioselective chloropalladation cyclization of 1,6-enynes RCCC(O)OCH2CH=CHCH2Cl (R = Et, Ph, thiophen-3-yl, 1-benzothiophen-3-yl, etc.). This reaction provides a redox-neutral approach to a variety of chiral α-chloromethylene-γ-butyrolactones I with excellent E selectivity and enantioselectivity. The precisely controlled coordination of palladium with both the in situ generated nucleophilic species and the monodentate phosphoramidite ligand is crucial for enantioselectivity. In the experiment, the researchers used many compounds, for example, 3-Iodobenzo[b]thiophene (cas: 36748-88-6Electric Literature of C8H5IS).
3-Iodobenzo[b]thiophene (cas: 36748-88-6) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Electric Literature of C8H5IS
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com